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A3KGW5 (GT253_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene names
Name:Cercam
Synonyms:Ceecam1, Glt25d3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentEndoplasmic reticulum
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

lipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 592573Probable inactive glycosyltransferase 25 family member 3
PRO_0000309545

Regions

Motif589 – 5924Prevents secretion from ER Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A3KGW5 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 8DB0093ACCCA8CB1

FASTA59267,672
        10         20         30         40         50         60 
MHVARLLPLL LLLGQQLRAA SVTEPTLPTV VLAILARNAE HSLPHYLGAL ERLDYPRARL 

        70         80         90        100        110        120 
ALWCATDHNM DNTTGMLREW LAAVGRDYAT VVWKPEEEAR SYPDEQGPKH WTKERHQFLM 

       130        140        150        160        170        180 
ELRQEALAFA RDWGADYILF ADTDNILTNN QTLKLLIDRQ LPVVAPMLDS QTYYSNFWCG 

       190        200        210        220        230        240 
ITPQGYYRRT AEYFPTKNRQ RQGCFRVPMV HSTFLLSLQT EETARLAFYP PHPNYSWPFD 

       250        260        270        280        290        300 
DIIVFAYACQ AAGVSMHVCN DHRYGYMNVV VKPHQSLEEE KTNFIHLILE ALVDGPPMLA 

       310        320        330        340        350        360 
SAHVSRPPKK LSKMGFDEVF VISLARRPQR RARMLSSLWE MEISAQVVDA VDGRTLNSSI 

       370        380        390        400        410        420 
LKHLGVDLLP GYQDPYSGHT LTKGEVGCFL SHYSIWEEVV ARGLARVVVF EDDVRFKDNF 

       430        440        450        460        470        480 
RRRLERLMED VLIQKLSWDL IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG 

       490        500        510        520        530        540 
ARKLLASQPL HRMLPVDEFL PVMFDRHPND QYKAYFWPRD LQAFSARPLL ASPTHYSGDA 

       550        560        570        580        590 
EWLSDTETSS PWDDDSGRLI SQTGSQKALR GPHLHLTGSS GHSLHPHHRD EL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928926 Genomic DNA. Translation: CAM46219.1.
CCDSCCDS15860.1.
RefSeqNP_997181.1. NM_207298.2.
UniGeneMm.296336.

3D structure databases

ProteinModelPortalA3KGW5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSiteA3KGW5.

Proteomic databases

PaxDbA3KGW5.
PRIDEA3KGW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
GeneID99151.
KEGGmmu:99151.
UCSCuc008jai.1. mouse.

Organism-specific databases

CTD51148.
MGIMGI:2139134. Cercam.

Phylogenomic databases

eggNOGCOG3306.
HOGENOMHOG000007198.
HOVERGENHBG058097.
InParanoidA3KGW5.
OMAEHRYGYM.
OrthoDBEOG7060RC.
PhylomeDBA3KGW5.
TreeFamTF313826.

Gene expression databases

BgeeA3KGW5.
CleanExMM_CERCAM.
GenevestigatorA3KGW5.

Family and domain databases

InterProIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCERCAM. mouse.
NextBio353807.
PROA3KGW5.
SOURCESearch...

Entry information

Entry nameGT253_MOUSE
AccessionPrimary (citable) accession number: A3KGW5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot