A3KGW5 (GT253_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inactive glycosyltransferase 25 family member 3

Alternative name(s):
Cerebral endothelial cell adhesion molecule

Gene names

Name:	Cercam
Synonyms:	Ceecam1, Glt25d3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.
Subcellular location	Endoplasmic reticulum lumen Potential.
Sequence similarities	Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Endoplasmic reticulum
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 592	573	Probable inactive glycosyltransferase 25 family member 3		PRO_0000309545
Regions
	Motif	589 – 592	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Glycosylation	234	1	N-linked (GlcNAc...) Potential
	Glycosylation	357	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A3KGW5 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 8DB0093ACCCA8CB1	FASTA	592	67,672
	10 20 30 40 50 60 MHVARLLPLL LLLGQQLRAA SVTEPTLPTV VLAILARNAE HSLPHYLGAL ERLDYPRARL 70 80 90 100 110 120 ALWCATDHNM DNTTGMLREW LAAVGRDYAT VVWKPEEEAR SYPDEQGPKH WTKERHQFLM 130 140 150 160 170 180 ELRQEALAFA RDWGADYILF ADTDNILTNN QTLKLLIDRQ LPVVAPMLDS QTYYSNFWCG 190 200 210 220 230 240 ITPQGYYRRT AEYFPTKNRQ RQGCFRVPMV HSTFLLSLQT EETARLAFYP PHPNYSWPFD 250 260 270 280 290 300 DIIVFAYACQ AAGVSMHVCN DHRYGYMNVV VKPHQSLEEE KTNFIHLILE ALVDGPPMLA 310 320 330 340 350 360 SAHVSRPPKK LSKMGFDEVF VISLARRPQR RARMLSSLWE MEISAQVVDA VDGRTLNSSI 370 380 390 400 410 420 LKHLGVDLLP GYQDPYSGHT LTKGEVGCFL SHYSIWEEVV ARGLARVVVF EDDVRFKDNF 430 440 450 460 470 480 RRRLERLMED VLIQKLSWDL IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG 490 500 510 520 530 540 ARKLLASQPL HRMLPVDEFL PVMFDRHPND QYKAYFWPRD LQAFSARPLL ASPTHYSGDA 550 560 570 580 590 EWLSDTETSS PWDDDSGRLI SQTGSQKALR GPHLHLTGSS GHSLHPHHRD EL

References

[1]

"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL928926 Genomic DNA. Translation: CAM46219.1.
IPI	IPI00348848.
RefSeq	NP_997181.1. NM_207298.2.
UniGene	Mm.296336.
3D structure databases
ProteinModelPortal	A3KGW5.
ModBase	Search...
Protein family/group databases
CAZy	GT25. Glycosyltransferase Family 25.
PTM databases
PhosphoSite	A3KGW5.
Proteomic databases
PaxDb	A3KGW5.
PRIDE	A3KGW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
GeneID	99151.
KEGG	mmu:99151.
Organism-specific databases
CTD	51148.
MGI	MGI:2139134. Cercam.
Phylogenomic databases
eggNOG	COG3306.
HOGENOM	HOG000007198.
HOVERGEN	HBG058097.
InParanoid	A3KGW5.
OMA	EYFPTKN.
OrthoDB	EOG4640BH.
Gene expression databases
ArrayExpress	A3KGW5.
Bgee	A3KGW5.
CleanEx	MM_CERCAM.
Genevestigator	A3KGW5.
Family and domain databases
InterPro	IPR002654. Glyco_trans_25. [Graphical view]
Pfam	PF01755. Glyco_transf_25. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CERCAM. mouse.
NextBio	353807.
SOURCE	Search...

Entry information

Entry name

GT253_MOUSE

Accession

Primary (citable) accession number: A3KGW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program