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A3KGW5

- GT253_MOUSE

UniProt

A3KGW5 - GT253_MOUSE

Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

Cercam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. lipopolysaccharide biosynthetic process Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    CAZyiGT25. Glycosyltransferase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable inactive glycosyltransferase 25 family member 3
    Alternative name(s):
    Cerebral endothelial cell adhesion molecule
    Gene namesi
    Name:Cercam
    Synonyms:Ceecam1, Glt25d3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2139134. Cercam.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 592573Probable inactive glycosyltransferase 25 family member 3PRO_0000309545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiA3KGW5.
    PRIDEiA3KGW5.

    PTM databases

    PhosphoSiteiA3KGW5.

    Expressioni

    Gene expression databases

    BgeeiA3KGW5.
    CleanExiMM_CERCAM.
    GenevestigatoriA3KGW5.

    Structurei

    3D structure databases

    ProteinModelPortaliA3KGW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi589 – 5924Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3306.
    HOGENOMiHOG000007198.
    HOVERGENiHBG058097.
    InParanoidiA3KGW5.
    OMAiEHRYGYM.
    OrthoDBiEOG7060RC.
    PhylomeDBiA3KGW5.
    TreeFamiTF313826.

    Family and domain databases

    InterProiIPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01755. Glyco_transf_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A3KGW5-1 [UniParc]FASTAAdd to Basket

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    MHVARLLPLL LLLGQQLRAA SVTEPTLPTV VLAILARNAE HSLPHYLGAL    50
    ERLDYPRARL ALWCATDHNM DNTTGMLREW LAAVGRDYAT VVWKPEEEAR 100
    SYPDEQGPKH WTKERHQFLM ELRQEALAFA RDWGADYILF ADTDNILTNN 150
    QTLKLLIDRQ LPVVAPMLDS QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ 200
    RQGCFRVPMV HSTFLLSLQT EETARLAFYP PHPNYSWPFD DIIVFAYACQ 250
    AAGVSMHVCN DHRYGYMNVV VKPHQSLEEE KTNFIHLILE ALVDGPPMLA 300
    SAHVSRPPKK LSKMGFDEVF VISLARRPQR RARMLSSLWE MEISAQVVDA 350
    VDGRTLNSSI LKHLGVDLLP GYQDPYSGHT LTKGEVGCFL SHYSIWEEVV 400
    ARGLARVVVF EDDVRFKDNF RRRLERLMED VLIQKLSWDL IYLGRKQVNP 450
    EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG ARKLLASQPL HRMLPVDEFL 500
    PVMFDRHPND QYKAYFWPRD LQAFSARPLL ASPTHYSGDA EWLSDTETSS 550
    PWDDDSGRLI SQTGSQKALR GPHLHLTGSS GHSLHPHHRD EL 592
    Length:592
    Mass (Da):67,672
    Last modified:April 3, 2007 - v1
    Checksum:i8DB0093ACCCA8CB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928926 Genomic DNA. Translation: CAM46219.1.
    CCDSiCCDS15860.1.
    RefSeqiNP_997181.1. NM_207298.2.
    UniGeneiMm.296336.

    Genome annotation databases

    EnsembliENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
    GeneIDi99151.
    KEGGimmu:99151.
    UCSCiuc008jai.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928926 Genomic DNA. Translation: CAM46219.1 .
    CCDSi CCDS15860.1.
    RefSeqi NP_997181.1. NM_207298.2.
    UniGenei Mm.296336.

    3D structure databases

    ProteinModelPortali A3KGW5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT25. Glycosyltransferase Family 25.

    PTM databases

    PhosphoSitei A3KGW5.

    Proteomic databases

    PaxDbi A3KGW5.
    PRIDEi A3KGW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047521 ; ENSMUSP00000041622 ; ENSMUSG00000039787 .
    GeneIDi 99151.
    KEGGi mmu:99151.
    UCSCi uc008jai.1. mouse.

    Organism-specific databases

    CTDi 51148.
    MGIi MGI:2139134. Cercam.

    Phylogenomic databases

    eggNOGi COG3306.
    HOGENOMi HOG000007198.
    HOVERGENi HBG058097.
    InParanoidi A3KGW5.
    OMAi EHRYGYM.
    OrthoDBi EOG7060RC.
    PhylomeDBi A3KGW5.
    TreeFami TF313826.

    Miscellaneous databases

    ChiTaRSi CERCAM. mouse.
    NextBioi 353807.
    PROi A3KGW5.
    SOURCEi Search...

    Gene expression databases

    Bgeei A3KGW5.
    CleanExi MM_CERCAM.
    Genevestigatori A3KGW5.

    Family and domain databases

    InterProi IPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01755. Glyco_transf_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiGT253_MOUSE
    AccessioniPrimary (citable) accession number: A3KGW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3