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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

Cercam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: MGI
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:Cercam
Synonyms:Ceecam1, Glt25d3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139134. Cercam.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 592573Probable inactive glycosyltransferase 25 family member 3PRO_0000309545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA3KGW5.
PaxDbiA3KGW5.
PRIDEiA3KGW5.

PTM databases

PhosphoSiteiA3KGW5.

Expressioni

Gene expression databases

BgeeiA3KGW5.
CleanExiMM_CERCAM.
ExpressionAtlasiA3KGW5. baseline and differential.
GenevestigatoriA3KGW5.

Structurei

3D structure databases

ProteinModelPortaliA3KGW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi589 – 5924Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA3KGW5.
OMAiEHRYGYM.
OrthoDBiEOG7060RC.
PhylomeDBiA3KGW5.
TreeFamiTF313826.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3KGW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVARLLPLL LLLGQQLRAA SVTEPTLPTV VLAILARNAE HSLPHYLGAL
60 70 80 90 100
ERLDYPRARL ALWCATDHNM DNTTGMLREW LAAVGRDYAT VVWKPEEEAR
110 120 130 140 150
SYPDEQGPKH WTKERHQFLM ELRQEALAFA RDWGADYILF ADTDNILTNN
160 170 180 190 200
QTLKLLIDRQ LPVVAPMLDS QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ
210 220 230 240 250
RQGCFRVPMV HSTFLLSLQT EETARLAFYP PHPNYSWPFD DIIVFAYACQ
260 270 280 290 300
AAGVSMHVCN DHRYGYMNVV VKPHQSLEEE KTNFIHLILE ALVDGPPMLA
310 320 330 340 350
SAHVSRPPKK LSKMGFDEVF VISLARRPQR RARMLSSLWE MEISAQVVDA
360 370 380 390 400
VDGRTLNSSI LKHLGVDLLP GYQDPYSGHT LTKGEVGCFL SHYSIWEEVV
410 420 430 440 450
ARGLARVVVF EDDVRFKDNF RRRLERLMED VLIQKLSWDL IYLGRKQVNP
460 470 480 490 500
EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG ARKLLASQPL HRMLPVDEFL
510 520 530 540 550
PVMFDRHPND QYKAYFWPRD LQAFSARPLL ASPTHYSGDA EWLSDTETSS
560 570 580 590
PWDDDSGRLI SQTGSQKALR GPHLHLTGSS GHSLHPHHRD EL
Length:592
Mass (Da):67,672
Last modified:April 3, 2007 - v1
Checksum:i8DB0093ACCCA8CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928926 Genomic DNA. Translation: CAM46219.1.
CCDSiCCDS15860.1.
RefSeqiNP_997181.1. NM_207298.2.
UniGeneiMm.296336.

Genome annotation databases

EnsembliENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
GeneIDi99151.
KEGGimmu:99151.
UCSCiuc008jai.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928926 Genomic DNA. Translation: CAM46219.1.
CCDSiCCDS15860.1.
RefSeqiNP_997181.1. NM_207298.2.
UniGeneiMm.296336.

3D structure databases

ProteinModelPortaliA3KGW5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSiteiA3KGW5.

Proteomic databases

MaxQBiA3KGW5.
PaxDbiA3KGW5.
PRIDEiA3KGW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
GeneIDi99151.
KEGGimmu:99151.
UCSCiuc008jai.1. mouse.

Organism-specific databases

CTDi51148.
MGIiMGI:2139134. Cercam.

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA3KGW5.
OMAiEHRYGYM.
OrthoDBiEOG7060RC.
PhylomeDBiA3KGW5.
TreeFamiTF313826.

Miscellaneous databases

ChiTaRSiCercam. mouse.
NextBioi353807.
PROiA3KGW5.
SOURCEiSearch...

Gene expression databases

BgeeiA3KGW5.
CleanExiMM_CERCAM.
ExpressionAtlasiA3KGW5. baseline and differential.
GenevestigatoriA3KGW5.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGT253_MOUSE
AccessioniPrimary (citable) accession number: A3KGW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 3, 2007
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.