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A3KGW5

- GT253_MOUSE

UniProt

A3KGW5 - GT253_MOUSE

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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene
Cercam, Ceecam1, Glt25d3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:Cercam
Synonyms:Ceecam1, Glt25d3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139134. Cercam.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 592573Probable inactive glycosyltransferase 25 family member 3PRO_0000309545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA3KGW5.
PRIDEiA3KGW5.

PTM databases

PhosphoSiteiA3KGW5.

Expressioni

Gene expression databases

BgeeiA3KGW5.
CleanExiMM_CERCAM.
GenevestigatoriA3KGW5.

Structurei

3D structure databases

ProteinModelPortaliA3KGW5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi589 – 5924Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA3KGW5.
OMAiEHRYGYM.
OrthoDBiEOG7060RC.
PhylomeDBiA3KGW5.
TreeFamiTF313826.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3KGW5-1 [UniParc]FASTAAdd to Basket

« Hide

MHVARLLPLL LLLGQQLRAA SVTEPTLPTV VLAILARNAE HSLPHYLGAL    50
ERLDYPRARL ALWCATDHNM DNTTGMLREW LAAVGRDYAT VVWKPEEEAR 100
SYPDEQGPKH WTKERHQFLM ELRQEALAFA RDWGADYILF ADTDNILTNN 150
QTLKLLIDRQ LPVVAPMLDS QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ 200
RQGCFRVPMV HSTFLLSLQT EETARLAFYP PHPNYSWPFD DIIVFAYACQ 250
AAGVSMHVCN DHRYGYMNVV VKPHQSLEEE KTNFIHLILE ALVDGPPMLA 300
SAHVSRPPKK LSKMGFDEVF VISLARRPQR RARMLSSLWE MEISAQVVDA 350
VDGRTLNSSI LKHLGVDLLP GYQDPYSGHT LTKGEVGCFL SHYSIWEEVV 400
ARGLARVVVF EDDVRFKDNF RRRLERLMED VLIQKLSWDL IYLGRKQVNP 450
EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG ARKLLASQPL HRMLPVDEFL 500
PVMFDRHPND QYKAYFWPRD LQAFSARPLL ASPTHYSGDA EWLSDTETSS 550
PWDDDSGRLI SQTGSQKALR GPHLHLTGSS GHSLHPHHRD EL 592
Length:592
Mass (Da):67,672
Last modified:April 3, 2007 - v1
Checksum:i8DB0093ACCCA8CB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928926 Genomic DNA. Translation: CAM46219.1.
CCDSiCCDS15860.1.
RefSeqiNP_997181.1. NM_207298.2.
UniGeneiMm.296336.

Genome annotation databases

EnsembliENSMUST00000047521; ENSMUSP00000041622; ENSMUSG00000039787.
GeneIDi99151.
KEGGimmu:99151.
UCSCiuc008jai.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928926 Genomic DNA. Translation: CAM46219.1 .
CCDSi CCDS15860.1.
RefSeqi NP_997181.1. NM_207298.2.
UniGenei Mm.296336.

3D structure databases

ProteinModelPortali A3KGW5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSitei A3KGW5.

Proteomic databases

PaxDbi A3KGW5.
PRIDEi A3KGW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047521 ; ENSMUSP00000041622 ; ENSMUSG00000039787 .
GeneIDi 99151.
KEGGi mmu:99151.
UCSCi uc008jai.1. mouse.

Organism-specific databases

CTDi 51148.
MGIi MGI:2139134. Cercam.

Phylogenomic databases

eggNOGi COG3306.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi A3KGW5.
OMAi EHRYGYM.
OrthoDBi EOG7060RC.
PhylomeDBi A3KGW5.
TreeFami TF313826.

Miscellaneous databases

ChiTaRSi CERCAM. mouse.
NextBioi 353807.
PROi A3KGW5.
SOURCEi Search...

Gene expression databases

Bgeei A3KGW5.
CleanExi MM_CERCAM.
Genevestigatori A3KGW5.

Family and domain databases

InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGT253_MOUSE
AccessioniPrimary (citable) accession number: A3KGW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi