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Protein
Submitted name:

Lysine-specific histone demethylase 1A

Gene

Kdm1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei331 – 3311FADUniRule annotation
Binding sitei337 – 3371FADUniRule annotation
Binding sitei822 – 8221FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi302 – 33029FADUniRule annotationAdd
BLAST
Nucleotide bindingi353 – 3542FADUniRule annotation
Nucleotide bindingi831 – 8322FADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific histone demethylase 1AImported
Gene namesi
Name:Kdm1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1196256. Kdm1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA3KG93.
PeptideAtlasiA3KG93.
PRIDEiA3KG93.

PTM databases

iPTMnetiA3KG93.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036940.
ExpressionAtlasiA3KG93. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111977.

Structurei

3D structure databases

ProteinModelPortaliA3KG93.
SMRiA3KG93. Positions 193-857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 294100SWIRMInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili114 – 14936Sequence analysisAdd
BLAST
Coiled coili455 – 48935Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains SWIRM domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
KOG0685. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00530000062888.
HOGENOMiHOG000246945.
HOVERGENiHBG102081.
OMAiPDWKQQA.
OrthoDBiEOG091G04NO.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR017366. Hist_Lys-spec_deMease.
IPR009057. Homeodomain-like.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF038051. Histone_Lys-demethylase. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51905. SSF51905. 3 hits.
PROSITEiPS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KG93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGKKAAAA AAAAAAAAAA GTEAGSGAAG GAENGSEVAA PPAGLTGPTD
60 70 80 90 100
MATGAAGERT PRKKEPPRAS PPGGLAEPPG SAGPQAGPTA GPGSATPMET
110 120 130 140 150
GIAETPEGRR TSRRKRAKVE YREMDESLAN LSEDEYYSEE ERNAKAEKEK
160 170 180 190 200
KLPPPPPQAP PEEENESEPE EPSGQAGGLQ DDSSGGYGDG QASGVEGAAF
210 220 230 240 250
QSRLPHDRMT SQEAACFPDI ISGPQQTQKV FLFIRNRTLQ LWLDNPKIQL
260 270 280 290 300
TFEATLQQLE APYNSDTVLV HRVHSYLERH GLINFGIYKR IKPLPIKKTG
310 320 330 340 350
KVIIIGSGVS GLAAARQLQS FGMDVTLLEA RDRVGGRVAT FRKGNYVADL
360 370 380 390 400
GAMVVTGLGG NPMAVVSKQV NMELAKIKQK CPLYEANGQA VPKEKDEMVE
410 420 430 440 450
QEFNRLLEAT SYLSHQLDFN VLNNKPVSLG QALEVVIQLQ EKHVKDEQIE
460 470 480 490 500
HWKKIVKTQE ELKELLNKMV NLKEKIKELH QQYKEASEVK PPRDITAEFL
510 520 530 540 550
VKSKHRDLTA LCKEYDELAE TQGKLEEKLQ ELEANPPSDV YLSSRDRQIL
560 570 580 590 600
DWHFANLEFA NATPLSTLSL KHWDQDDDFE FTGSHLTVRN GYSCVPVALA
610 620 630 640 650
EGLDIKLNTA VRQVRYTASG CEVIAVNTRS TSQTFIYKCD AVLCTLPLGV
660 670 680 690 700
LKQQPPAVQF VPPLPEWKTS AVQRMGFGNL NKVVLCFDRV FWDPSVNLFG
710 720 730 740 750
HVGSTTASRG ELFLFWNLYK APILLALVAG EAAGIMENIS DDVIVGRCLA
760 770 780 790 800
ILKGIFGSSA VPQPKETVVS RWRADPWARG SYSYVAAGSS GNDYDLMAQP
810 820 830 840 850
ITPGPSIPGA PQPIPRLFFA GEHTIRNYPA TVHGALLSGL REAGRIADQF
860 870
LGAMYTLPRQ ATPGVPAQQS PSM
Length:873
Mass (Da):94,659
Last modified:April 3, 2007 - v1
Checksum:iA4B902DC13C6A986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671173 Genomic DNA. No translation available.
RefSeqiXP_006539393.1. XM_006539330.2.
UniGeneiMm.28540.

Genome annotation databases

EnsembliENSMUST00000105847; ENSMUSP00000101473; ENSMUSG00000036940.
GeneIDi99982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671173 Genomic DNA. No translation available.
RefSeqiXP_006539393.1. XM_006539330.2.
UniGeneiMm.28540.

3D structure databases

ProteinModelPortaliA3KG93.
SMRiA3KG93. Positions 193-857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111977.

PTM databases

iPTMnetiA3KG93.

Proteomic databases

PaxDbiA3KG93.
PeptideAtlasiA3KG93.
PRIDEiA3KG93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105847; ENSMUSP00000101473; ENSMUSG00000036940.
GeneIDi99982.

Organism-specific databases

CTDi23028.
MGIiMGI:1196256. Kdm1a.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
KOG0685. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00530000062888.
HOGENOMiHOG000246945.
HOVERGENiHBG102081.
OMAiPDWKQQA.
OrthoDBiEOG091G04NO.

Miscellaneous databases

ChiTaRSiKdm1a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036940.
ExpressionAtlasiA3KG93. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR017366. Hist_Lys-spec_deMease.
IPR009057. Homeodomain-like.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF038051. Histone_Lys-demethylase. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51905. SSF51905. 3 hits.
PROSITEiPS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA3KG93_MOUSE
AccessioniPrimary (citable) accession number: A3KG93
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.