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Protein
Submitted name:

Lysine-specific histone demethylase 1A

Gene

Kdm1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei331FADUniRule annotation1
Binding sitei337FADUniRule annotation1
Binding sitei822FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi302 – 330FADUniRule annotationAdd BLAST29
Nucleotide bindingi353 – 354FADUniRule annotation2
Nucleotide bindingi831 – 832FADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandFADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific histone demethylase 1AImported
Gene namesi
Name:Kdm1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1196256. Kdm1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA3KG93.
PaxDbiA3KG93.
PeptideAtlasiA3KG93.
PRIDEiA3KG93.

PTM databases

iPTMnetiA3KG93.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036940.
ExpressionAtlasiA3KG93. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA3KG93.
SMRiA3KG93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 294SWIRMInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 149Sequence analysisAdd BLAST36
Coiled coili455 – 489Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
KOG0685. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00530000062888.
HOGENOMiHOG000246945.
HOVERGENiHBG102081.
OMAiTTVRNGY.
OrthoDBiEOG091G04NO.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR002937. Amino_oxidase.
IPR036188. FAD/NAD-bd_sf.
IPR017366. Hist_Lys-spec_deMease.
IPR009057. Homeobox-like.
IPR007526. SWIRM.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF01593. Amino_oxidase. 1 hit.
PF04433. SWIRM. 1 hit.
PIRSFiPIRSF038051. Histone_Lys-demethylase. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51905. SSF51905. 3 hits.
PROSITEiView protein in PROSITE
PS50934. SWIRM. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KG93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGKKAAAA AAAAAAAAAA GTEAGSGAAG GAENGSEVAA PPAGLTGPTD
60 70 80 90 100
MATGAAGERT PRKKEPPRAS PPGGLAEPPG SAGPQAGPTA GPGSATPMET
110 120 130 140 150
GIAETPEGRR TSRRKRAKVE YREMDESLAN LSEDEYYSEE ERNAKAEKEK
160 170 180 190 200
KLPPPPPQAP PEEENESEPE EPSGQAGGLQ DDSSGGYGDG QASGVEGAAF
210 220 230 240 250
QSRLPHDRMT SQEAACFPDI ISGPQQTQKV FLFIRNRTLQ LWLDNPKIQL
260 270 280 290 300
TFEATLQQLE APYNSDTVLV HRVHSYLERH GLINFGIYKR IKPLPIKKTG
310 320 330 340 350
KVIIIGSGVS GLAAARQLQS FGMDVTLLEA RDRVGGRVAT FRKGNYVADL
360 370 380 390 400
GAMVVTGLGG NPMAVVSKQV NMELAKIKQK CPLYEANGQA VPKEKDEMVE
410 420 430 440 450
QEFNRLLEAT SYLSHQLDFN VLNNKPVSLG QALEVVIQLQ EKHVKDEQIE
460 470 480 490 500
HWKKIVKTQE ELKELLNKMV NLKEKIKELH QQYKEASEVK PPRDITAEFL
510 520 530 540 550
VKSKHRDLTA LCKEYDELAE TQGKLEEKLQ ELEANPPSDV YLSSRDRQIL
560 570 580 590 600
DWHFANLEFA NATPLSTLSL KHWDQDDDFE FTGSHLTVRN GYSCVPVALA
610 620 630 640 650
EGLDIKLNTA VRQVRYTASG CEVIAVNTRS TSQTFIYKCD AVLCTLPLGV
660 670 680 690 700
LKQQPPAVQF VPPLPEWKTS AVQRMGFGNL NKVVLCFDRV FWDPSVNLFG
710 720 730 740 750
HVGSTTASRG ELFLFWNLYK APILLALVAG EAAGIMENIS DDVIVGRCLA
760 770 780 790 800
ILKGIFGSSA VPQPKETVVS RWRADPWARG SYSYVAAGSS GNDYDLMAQP
810 820 830 840 850
ITPGPSIPGA PQPIPRLFFA GEHTIRNYPA TVHGALLSGL REAGRIADQF
860 870
LGAMYTLPRQ ATPGVPAQQS PSM
Length:873
Mass (Da):94,659
Last modified:April 3, 2007 - v1
Checksum:iA4B902DC13C6A986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671173 Genomic DNA. No translation available.
RefSeqiNP_001334150.1. NM_001347221.1.
UniGeneiMm.28540.

Genome annotation databases

EnsembliENSMUST00000105847; ENSMUSP00000101473; ENSMUSG00000036940.
GeneIDi99982.

Similar proteinsi

Entry informationi

Entry nameiA3KG93_MOUSE
AccessioniPrimary (citable) accession number: A3KG93
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported