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A3KG01 (A3KG01_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Ephrin type-B receptor 2 Ensembl ENSMUSP00000101471
Gene names
Name:Ephb2 EMBL AAH43088.2 MGI 99611 Ensembl ENSMUSP00000101471
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH43088.2
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length986 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS009030

Sequence similarities

Contains Eph LBD (Eph ligand-binding) domain. SAAS SAAS001090

Contains SAM (sterile alpha motif) domain. SAAS SAAS013761

Contains protein kinase domain. SAAS SAAS009030

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat SAAS SAAS009030
Transmembrane
Transmembrane helix SAAS SAAS009030
   LigandATP-binding SAAS SAAS009030
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS009030 EMBL AAH43088.2
Transferase
Tyrosine-protein kinase SAAS SAAS009030
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from direct assay PubMed 11532925. Source: MGI

camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 12971893. Source: MGI

cell morphogenesis

Inferred from genetic interaction PubMed 17686994. Source: MGI

central nervous system projection neuron axonogenesis

Inferred from mutant phenotype PubMed 12971893. Source: MGI

ephrin receptor signaling pathway

Inferred from direct assay PubMed 17686994. Source: MGI

learning

Inferred from mutant phenotype PubMed 11754835. Source: MGI

negative regulation of axonogenesis

Inferred from direct assay PubMed 12971893. Source: MGI

optic nerve morphogenesis

Inferred from mutant phenotype PubMed 12971893. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 15223334. Source: MGI

peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 17686994. Source: MGI

positive regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 11754836. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 12971893. Source: MGI

regulation of axonogenesis

Inferred from direct assay PubMed 14988728. Source: MGI

regulation of neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 11754835. Source: MGI

retinal ganglion cell axon guidance

Inferred from direct assay PubMed 12971893. Source: MGI

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from direct assay PubMed 14988728. Source: MGI

   Cellular_componentintegral component of plasma membrane

Traceable author statement PubMed 11532925. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 12971893. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

axon guidance receptor activity

Inferred from direct assay PubMed 11532925. Source: MGI

ephrin receptor activity

Inferred from direct assay PubMed 11780069. Source: MGI

receptor activity

Inferred from direct assay PubMed 11780069. Source: MGI

receptor binding

Inferred from physical interaction PubMed 11754835. Source: MGI

transmembrane-ephrin receptor activity

Traceable author statement PubMed 11532925. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A3KG01 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 92DB5234F18758A7

FASTA986109,899
        10         20         30         40         50         60 
MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 

        70         80         90        100        110        120 
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 

       130        140        150        160        170        180 
DLATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD 

       190        200        210        220        230        240 
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 

       250        260        270        280        290        300 
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 

       310        320        330        340        350        360 
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 

       370        380        390        400        410        420 
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 

       430        440        450        460        470        480 
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 

       490        500        510        520        530        540 
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK 

       550        560        570        580        590        600 
LPLIVGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 

       610        620        630        640        650        660 
TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 

       670        680        690        700        710        720 
EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 

       730        740        750        760        770        780 
IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 

       790        800        810        820        830        840 
TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 

       850        860        870        880        890        900 
QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 

       910        920        930        940        950        960 
NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 

       970        980 
AGHQKKILNS IQVMRAQMNQ IQSVEV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH43088.2.
Tissue: Brain EMBL AAH43088.2.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000101471.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000101471.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL627214 Genomic DNA. No translation available.
AL627345 Genomic DNA. No translation available.
AL671173 Genomic DNA. No translation available.
BC043088 mRNA. Translation: AAH43088.2.
RefSeqNP_034272.1. NM_010142.2.
UniGeneMm.250981.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU13844.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105845; ENSMUSP00000101471; ENSMUSG00000028664.
GeneID13844.
KEGGmmu:13844.
UCSCuc008vim.1. mouse.

Organism-specific databases

CTD2048.
MGIMGI:99611. Ephb2.

Phylogenomic databases

GeneTreeENSGT00740000115081.
HOVERGENHBG062180.
KOK05111.
OrthoDBEOG7VTDM6.

Gene expression databases

GenevestigatorA3KG01.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEPHB2. mouse.
NextBio284684.
PMAP-CutDBA3KG01.
SOURCESearch...

Entry information

Entry nameA3KG01_MOUSE
AccessionPrimary (citable) accession number: A3KG01
Secondary accession number(s): A3KG90, Q6GTQ7
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)