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Protein

Receptor protein-tyrosine kinase

Gene

Ephb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei654 – 6541ATPUniRule annotation
Active sitei747 – 7471Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi628 – 6369ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. axon guidance receptor activity Source: MGI
  3. ephrin receptor activity Source: MGI
  4. receptor activity Source: MGI
  5. receptor binding Source: MGI
  6. transmembrane-ephrin receptor activity Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. camera-type eye morphogenesis Source: MGI
  3. cell morphogenesis Source: MGI
  4. central nervous system projection neuron axonogenesis Source: MGI
  5. dendritic spine morphogenesis Source: MGI
  6. ephrin receptor signaling pathway Source: MGI
  7. learning Source: MGI
  8. negative regulation of axonogenesis Source: MGI
  9. optic nerve morphogenesis Source: MGI
  10. organ morphogenesis Source: MGI
  11. peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of long-term neuronal synaptic plasticity Source: MGI
  13. protein phosphorylation Source: MGI
  14. regulation of axonogenesis Source: MGI
  15. regulation of neuronal synaptic plasticity Source: MGI
  16. retinal ganglion cell axon guidance Source: MGI
  17. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_278281. Ephrin signaling.
REACT_292566. EPH-Ephrin signaling.
REACT_302308. L1CAM interactions.
REACT_313804. EPHB-mediated forward signaling.
REACT_314615. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:Ephb2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99611. Ephb2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiA3KG00.
ExpressionAtlasiA3KG00. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA3KG00.
SMRiA3KG00. Positions 18-986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains SAM (sterile alpha motif) domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118975.
HOVERGENiHBG062180.
KOiK05111.
TreeFamiTF315608.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KG00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD
60 70 80 90 100
ENMNTIRTYQ VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI
110 120 130 140 150
PSVPGSCKET FNLYYYEADF DLATKTFPNW MENPWVKVDT IAADESFSQV
160 170 180 190 200
DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD YGGCMSLIAV RVFYRKCPRI
210 220 230 240 250
IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY CNGDGEWLVP
260 270 280 290 300
IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
310 320 330 340 350
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS
360 370 380 390 400
GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA
410 420 430 440 450
HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD
460 470 480 490 500
SITLSWSQPD QPNGVILDYE LQYYEKELSE YNATAIKSPT NTVTVQGLKA
510 520 530 540 550
GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK LPLIVGSSAA
560 570 580 590 600
GLVFLIAVVV IAIVCNRRRG FERADSEYTD KLQHYTSGHM TPGMKIYIDP
610 620 630 640 650
FTYEDPNEAV REFAKEIDIS CVKIEQVIGA GEFGEVCSGH LKLPGKREIF
660 670 680 690 700
VAIKTLKSGY TEKQRRDFLS EASIMGQFDH PNVIHLEGVV TKSTPVMIIT
710 720 730 740 750
EFMENGSLDS FLRQNDGQFT VIQLVGMLRG IAAGMKYLAD MNYVHRDLAA
760 770 780 790 800
RNILVNSNLV CKVSDFGLSR FLEDDTSDPT YTSALGGKIP IRWTAPEAIQ
810 820 830 840 850
YRKFTSASDV WSYGIVMWEV MSYGERPYWD MTNQDVINAI EQDYRLPPPM
860 870 880 890 900
DCPSALHQLM LDCWQKDRNH RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG
910 920 930 940 950
INLPLLDRTI PDYTSFNTVD EWLEAIKMGQ YKESFANAGF TSFDVVSQMM
960 970 980
MEDILRVGVT LAGHQKKILN SIQVMRAQMN QIQSVEV
Length:987
Mass (Da):110,055
Last modified:August 21, 2007 - v2
Checksum:iEE04E7A723307E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627214 Genomic DNA. No translation available.
AL627345 Genomic DNA. No translation available.
AL671173 Genomic DNA. No translation available.
RefSeqiXP_006538594.1. XM_006538531.2.
UniGeneiMm.250981.

Genome annotation databases

EnsembliENSMUST00000105846; ENSMUSP00000101472; ENSMUSG00000028664.
GeneIDi13844.
KEGGimmu:13844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627214 Genomic DNA. No translation available.
AL627345 Genomic DNA. No translation available.
AL671173 Genomic DNA. No translation available.
RefSeqiXP_006538594.1. XM_006538531.2.
UniGeneiMm.250981.

3D structure databases

ProteinModelPortaliA3KG00.
SMRiA3KG00. Positions 18-986.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105846; ENSMUSP00000101472; ENSMUSG00000028664.
GeneIDi13844.
KEGGimmu:13844.

Organism-specific databases

CTDi2048.
MGIiMGI:99611. Ephb2.

Phylogenomic databases

GeneTreeiENSGT00760000118975.
HOVERGENiHBG062180.
KOiK05111.
TreeFamiTF315608.

Enzyme and pathway databases

ReactomeiREACT_278281. Ephrin signaling.
REACT_292566. EPH-Ephrin signaling.
REACT_302308. L1CAM interactions.
REACT_313804. EPHB-mediated forward signaling.
REACT_314615. EPH-ephrin mediated repulsion of cells.

Miscellaneous databases

ChiTaRSiEphb2. mouse.
NextBioi35544607.
SOURCEiSearch...

Gene expression databases

BgeeiA3KG00.
ExpressionAtlasiA3KG00. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA3KG00_MOUSE
AccessioniPrimary (citable) accession number: A3KG00
Secondary accession number(s): A3KG89
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: August 21, 2007
Last modified: April 1, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.