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A3KG00

- A3KG00_MOUSE

UniProt

A3KG00 - A3KG00_MOUSE

Protein
Submitted name:

Ephrin type-B receptor 2

Gene

Ephb2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. axon guidance receptor activity Source: MGI
    3. ephrin receptor activity Source: MGI
    4. protein binding Source: MGI
    5. receptor activity Source: MGI
    6. receptor binding Source: MGI
    7. transmembrane-ephrin receptor activity Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. camera-type eye morphogenesis Source: MGI
    3. cell morphogenesis Source: MGI
    4. central nervous system projection neuron axonogenesis Source: MGI
    5. ephrin receptor signaling pathway Source: MGI
    6. learning Source: MGI
    7. negative regulation of axonogenesis Source: MGI
    8. optic nerve morphogenesis Source: MGI
    9. organ morphogenesis Source: MGI
    10. peptidyl-tyrosine phosphorylation Source: MGI
    11. positive regulation of long-term neuronal synaptic plasticity Source: MGI
    12. protein phosphorylation Source: MGI
    13. regulation of axonogenesis Source: MGI
    14. regulation of neuronal synaptic plasticity Source: MGI
    15. retinal ganglion cell axon guidance Source: MGI
    16. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_219680. L1CAM interactions.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ephrin type-B receptor 2Imported
    Gene namesi
    Name:Ephb2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:99611. Ephb2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliA3KG00.
    SMRiA3KG00. Positions 18-986.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains SAM (sterile alpha motif) domain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115081.
    HOVERGENiHBG062180.
    InParanoidiA3KG00.
    KOiK05111.
    TreeFamiTF315608.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07699. GCC2_GCC3. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3KG00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD    50
    ENMNTIRTYQ VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI 100
    PSVPGSCKET FNLYYYEADF DLATKTFPNW MENPWVKVDT IAADESFSQV 150
    DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD YGGCMSLIAV RVFYRKCPRI 200
    IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY CNGDGEWLVP 250
    IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 300
    TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS 350
    GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA 400
    HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD 450
    SITLSWSQPD QPNGVILDYE LQYYEKELSE YNATAIKSPT NTVTVQGLKA 500
    GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK LPLIVGSSAA 550
    GLVFLIAVVV IAIVCNRRRG FERADSEYTD KLQHYTSGHM TPGMKIYIDP 600
    FTYEDPNEAV REFAKEIDIS CVKIEQVIGA GEFGEVCSGH LKLPGKREIF 650
    VAIKTLKSGY TEKQRRDFLS EASIMGQFDH PNVIHLEGVV TKSTPVMIIT 700
    EFMENGSLDS FLRQNDGQFT VIQLVGMLRG IAAGMKYLAD MNYVHRDLAA 750
    RNILVNSNLV CKVSDFGLSR FLEDDTSDPT YTSALGGKIP IRWTAPEAIQ 800
    YRKFTSASDV WSYGIVMWEV MSYGERPYWD MTNQDVINAI EQDYRLPPPM 850
    DCPSALHQLM LDCWQKDRNH RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG 900
    INLPLLDRTI PDYTSFNTVD EWLEAIKMGQ YKESFANAGF TSFDVVSQMM 950
    MEDILRVGVT LAGHQKKILN SIQVMRAQMN QIQSVEV 987
    Length:987
    Mass (Da):110,055
    Last modified:August 21, 2007 - v2
    Checksum:iEE04E7A723307E4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627214 Genomic DNA. No translation available.
    AL627345 Genomic DNA. No translation available.
    AL671173 Genomic DNA. No translation available.
    RefSeqiXP_006538594.1. XM_006538531.1.
    UniGeneiMm.250981.

    Genome annotation databases

    EnsembliENSMUST00000105846; ENSMUSP00000101472; ENSMUSG00000028664.
    GeneIDi13844.
    KEGGimmu:13844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627214 Genomic DNA. No translation available.
    AL627345 Genomic DNA. No translation available.
    AL671173 Genomic DNA. No translation available.
    RefSeqi XP_006538594.1. XM_006538531.1.
    UniGenei Mm.250981.

    3D structure databases

    ProteinModelPortali A3KG00.
    SMRi A3KG00. Positions 18-986.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105846 ; ENSMUSP00000101472 ; ENSMUSG00000028664 .
    GeneIDi 13844.
    KEGGi mmu:13844.

    Organism-specific databases

    CTDi 2048.
    MGIi MGI:99611. Ephb2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115081.
    HOVERGENi HBG062180.
    InParanoidi A3KG00.
    KOi K05111.
    TreeFami TF315608.

    Enzyme and pathway databases

    Reactomei REACT_219680. L1CAM interactions.

    Miscellaneous databases

    ChiTaRSi EPHB2. mouse.
    NextBioi 35544607.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07699. GCC2_GCC3. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA3KG00_MOUSE
    AccessioniPrimary (citable) accession number: A3KG00
    Secondary accession number(s): A3KG89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3