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Protein

Cytosolic 5'-nucleotidase 1A

Gene

Nt5c1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).By similarity

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by ADP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

  • adenosine metabolic process Source: Ensembl
  • dephosphorylation Source: MGI
  • nucleotide metabolic process Source: UniProtKB-KW
  • purine nucleoside monophosphate catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-73621. Pyrimidine catabolism.
R-MMU-74259. Purine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 1A (EC:3.1.3.5)
Short name:
cN1A
Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name:
cN-IA
Gene namesi
Name:Nt5c1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2155700. Nt5c1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Cytosolic 5'-nucleotidase 1APRO_0000304930Add
BLAST

Proteomic databases

MaxQBiA3KFX0.
PaxDbiA3KFX0.
PRIDEiA3KFX0.

PTM databases

iPTMnetiA3KFX0.
PhosphoSiteiA3KFX0.

Expressioni

Gene expression databases

BgeeiA3KFX0.
CleanExiMM_NT5C1A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422.

Structurei

3D structure databases

ProteinModelPortaliA3KFX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 5'-nucleotidase type 3 family.Curated

Phylogenomic databases

eggNOGiENOG410IE01. Eukaryota.
ENOG410XPRD. LUCA.
GeneTreeiENSGT00390000017767.
HOGENOMiHOG000243802.
HOVERGENiHBG101325.
InParanoidiA3KFX0.
KOiK01081.
OMAiAADVFFD.
OrthoDBiEOG79KPF1.
TreeFamiTF329831.

Family and domain databases

InterProiIPR010394. 5-nucleotidase.
[Graphical view]
PfamiPF06189. 5-nucleotidase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KFX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGQPREAR EPGPGAETAA VPRWEEAKTF YDNLSSKKKP KSPKPQNAVT
60 70 80 90 100
IAVSSRALFR MDEEQRIYTE QGVEEYVRYQ LEHENEPFSP GPAFPFVKAL
110 120 130 140 150
EAVNKRLREL YPDSEDIFDI VLMTNNHAQV GVRLINSINH YDLFIERFCM
160 170 180 190 200
TGGNSPICYL KAYHTNLYLS ADADKVREAI DEGIAAATIF SPSRDVVVSQ
210 220 230 240 250
SQLRVAFDGD AVLFSDESER IVKAHGLDRF FEHEKAHENK PLAQGPLKGF
260 270 280 290 300
LEALGRLQKK FYSKGLRLEC PIRTYLVTAR SAASSGARAL KTLRSWGLET
310 320 330 340 350
DEALFLAGAP KGPLLEKIRP HIFFDDQMFH VAGAQEMGTV AAHVPYGVAQ
360
NPRRAAAAKQ SLGAQ
Length:365
Mass (Da):40,678
Last modified:April 3, 2007 - v1
Checksum:i10DBCBE793C69D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30387.1.
BC147308 mRNA. Translation: AAI47309.1.
BC147309 mRNA. Translation: AAI47310.1.
BC147730 mRNA. Translation: AAI47731.1.
BC147733 mRNA. Translation: AAI47734.1.
CCDSiCCDS38871.1.
RefSeqiNP_001078971.1. NM_001085502.1.
UniGeneiMm.354635.

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958.
GeneIDi230718.
KEGGimmu:230718.
UCSCiuc008uoy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30387.1.
BC147308 mRNA. Translation: AAI47309.1.
BC147309 mRNA. Translation: AAI47310.1.
BC147730 mRNA. Translation: AAI47731.1.
BC147733 mRNA. Translation: AAI47734.1.
CCDSiCCDS38871.1.
RefSeqiNP_001078971.1. NM_001085502.1.
UniGeneiMm.354635.

3D structure databases

ProteinModelPortaliA3KFX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422.

PTM databases

iPTMnetiA3KFX0.
PhosphoSiteiA3KFX0.

Proteomic databases

MaxQBiA3KFX0.
PaxDbiA3KFX0.
PRIDEiA3KFX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958.
GeneIDi230718.
KEGGimmu:230718.
UCSCiuc008uoy.1. mouse.

Organism-specific databases

CTDi84618.
MGIiMGI:2155700. Nt5c1a.

Phylogenomic databases

eggNOGiENOG410IE01. Eukaryota.
ENOG410XPRD. LUCA.
GeneTreeiENSGT00390000017767.
HOGENOMiHOG000243802.
HOVERGENiHBG101325.
InParanoidiA3KFX0.
KOiK01081.
OMAiAADVFFD.
OrthoDBiEOG79KPF1.
TreeFamiTF329831.

Enzyme and pathway databases

ReactomeiR-MMU-73621. Pyrimidine catabolism.
R-MMU-74259. Purine catabolism.

Miscellaneous databases

NextBioi380069.
PROiA3KFX0.
SOURCEiSearch...

Gene expression databases

BgeeiA3KFX0.
CleanExiMM_NT5C1A.

Family and domain databases

InterProiIPR010394. 5-nucleotidase.
[Graphical view]
PfamiPF06189. 5-nucleotidase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry namei5NT1A_MOUSE
AccessioniPrimary (citable) accession number: A3KFX0
Secondary accession number(s): B2RVQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: April 3, 2007
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.