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Protein

Cytosolic 5'-nucleotidase 1A

Gene

Nt5c1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).By similarity

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by ADP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei208NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adenosine metabolic process Source: Ensembl
  • nucleotide metabolic process Source: UniProtKB-KW
  • purine nucleoside monophosphate catabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-73621. Pyrimidine catabolism.
R-MMU-74259. Purine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 1A (EC:3.1.3.5)
Short name:
cN1A
Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name:
cN-IA
Gene namesi
Name:Nt5c1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2155700. Nt5c1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049301 – 365Cytosolic 5'-nucleotidase 1AAdd BLAST365

Proteomic databases

MaxQBiA3KFX0.
PaxDbiA3KFX0.
PeptideAtlasiA3KFX0.
PRIDEiA3KFX0.

PTM databases

iPTMnetiA3KFX0.
PhosphoSitePlusiA3KFX0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054958.
CleanExiMM_NT5C1A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422.

Structurei

3D structure databases

ProteinModelPortaliA3KFX0.
SMRiA3KFX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 5'-nucleotidase type 3 family.Curated

Phylogenomic databases

eggNOGiENOG410IE01. Eukaryota.
ENOG410XPRD. LUCA.
GeneTreeiENSGT00390000017767.
HOGENOMiHOG000243802.
HOVERGENiHBG101325.
InParanoidiA3KFX0.
KOiK01081.
OMAiHENEPFA.
OrthoDBiEOG091G0EZE.
TreeFamiTF329831.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR010394. 5-nucleotidase.
IPR023214. HAD-like_dom.
PfamiView protein in Pfam
PF06189. 5-nucleotidase. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KFX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGQPREAR EPGPGAETAA VPRWEEAKTF YDNLSSKKKP KSPKPQNAVT
60 70 80 90 100
IAVSSRALFR MDEEQRIYTE QGVEEYVRYQ LEHENEPFSP GPAFPFVKAL
110 120 130 140 150
EAVNKRLREL YPDSEDIFDI VLMTNNHAQV GVRLINSINH YDLFIERFCM
160 170 180 190 200
TGGNSPICYL KAYHTNLYLS ADADKVREAI DEGIAAATIF SPSRDVVVSQ
210 220 230 240 250
SQLRVAFDGD AVLFSDESER IVKAHGLDRF FEHEKAHENK PLAQGPLKGF
260 270 280 290 300
LEALGRLQKK FYSKGLRLEC PIRTYLVTAR SAASSGARAL KTLRSWGLET
310 320 330 340 350
DEALFLAGAP KGPLLEKIRP HIFFDDQMFH VAGAQEMGTV AAHVPYGVAQ
360
NPRRAAAAKQ SLGAQ
Length:365
Mass (Da):40,678
Last modified:April 3, 2007 - v1
Checksum:i10DBCBE793C69D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30387.1.
BC147308 mRNA. Translation: AAI47309.1.
BC147309 mRNA. Translation: AAI47310.1.
BC147730 mRNA. Translation: AAI47731.1.
BC147733 mRNA. Translation: AAI47734.1.
CCDSiCCDS38871.1.
RefSeqiNP_001078971.1. NM_001085502.1.
UniGeneiMm.354635.

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958.
GeneIDi230718.
KEGGimmu:230718.
UCSCiuc008uoy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30387.1.
BC147308 mRNA. Translation: AAI47309.1.
BC147309 mRNA. Translation: AAI47310.1.
BC147730 mRNA. Translation: AAI47731.1.
BC147733 mRNA. Translation: AAI47734.1.
CCDSiCCDS38871.1.
RefSeqiNP_001078971.1. NM_001085502.1.
UniGeneiMm.354635.

3D structure databases

ProteinModelPortaliA3KFX0.
SMRiA3KFX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422.

PTM databases

iPTMnetiA3KFX0.
PhosphoSitePlusiA3KFX0.

Proteomic databases

MaxQBiA3KFX0.
PaxDbiA3KFX0.
PeptideAtlasiA3KFX0.
PRIDEiA3KFX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958.
GeneIDi230718.
KEGGimmu:230718.
UCSCiuc008uoy.1. mouse.

Organism-specific databases

CTDi84618.
MGIiMGI:2155700. Nt5c1a.

Phylogenomic databases

eggNOGiENOG410IE01. Eukaryota.
ENOG410XPRD. LUCA.
GeneTreeiENSGT00390000017767.
HOGENOMiHOG000243802.
HOVERGENiHBG101325.
InParanoidiA3KFX0.
KOiK01081.
OMAiHENEPFA.
OrthoDBiEOG091G0EZE.
TreeFamiTF329831.

Enzyme and pathway databases

ReactomeiR-MMU-73621. Pyrimidine catabolism.
R-MMU-74259. Purine catabolism.

Miscellaneous databases

PROiPR:A3KFX0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054958.
CleanExiMM_NT5C1A.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR010394. 5-nucleotidase.
IPR023214. HAD-like_dom.
PfamiView protein in Pfam
PF06189. 5-nucleotidase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei5NT1A_MOUSE
AccessioniPrimary (citable) accession number: A3KFX0
Secondary accession number(s): B2RVQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: April 3, 2007
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.