A3KFX0 (5NT1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic 5'-nucleotidase 1A
Short name=cN1A
EC=3.1.3.5

Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name=cN-IA

Gene names

Name:

Nt5c1a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated by ADP By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 5'-nucleotidase type 3 family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Cytosolic 5'-nucleotidase 1A		PRO_0000304930
Sites
	Active site	208	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3KFX0 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 10DBCBE793C69D64	FASTA	365	40,678
	10 20 30 40 50 60 MEPGQPREAR EPGPGAETAA VPRWEEAKTF YDNLSSKKKP KSPKPQNAVT IAVSSRALFR 70 80 90 100 110 120 MDEEQRIYTE QGVEEYVRYQ LEHENEPFSP GPAFPFVKAL EAVNKRLREL YPDSEDIFDI 130 140 150 160 170 180 VLMTNNHAQV GVRLINSINH YDLFIERFCM TGGNSPICYL KAYHTNLYLS ADADKVREAI 190 200 210 220 230 240 DEGIAAATIF SPSRDVVVSQ SQLRVAFDGD AVLFSDESER IVKAHGLDRF FEHEKAHENK 250 260 270 280 290 300 PLAQGPLKGF LEALGRLQKK FYSKGLRLEC PIRTYLVTAR SAASSGARAL KTLRSWGLET 310 320 330 340 350 360 DEALFLAGAP KGPLLEKIRP HIFFDDQMFH VAGAQEMGTV AAHVPYGVAQ NPRRAAAAKQ SLGAQ

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL606934 Genomic DNA. No translation available. CH466552 Genomic DNA. Translation: EDL30387.1. BC147308 mRNA. Translation: AAI47309.1. BC147309 mRNA. Translation: AAI47310.1. BC147730 mRNA. Translation: AAI47731.1. BC147733 mRNA. Translation: AAI47734.1.
IPI	IPI00346135.
RefSeq	NP_001078971.1. NM_001085502.1.
UniGene	Mm.354635.
3D structure databases
ProteinModelPortal	A3KFX0.
ModBase	Search...
Protein-protein interaction databases
STRING	A3KFX0.
PTM databases
PhosphoSite	A3KFX0.
Proteomic databases
PRIDE	A3KFX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958.
GeneID	230718.
KEGG	mmu:230718.
NMPDR	fig|10090.3.peg.10310.
UCSC	uc008uoy.1. mouse.
Organism-specific databases
CTD	84618.
MGI	MGI:2155700. Nt5c1a.
Phylogenomic databases
eggNOG	roNOG14659.
GeneTree	ENSGT00390000017767.
HOGENOM	HBG350968.
HOVERGEN	HBG101325.
InParanoid	A3KFX0.
OMA	LEHENEP.
OrthoDB	EOG4PNXHC.
Gene expression databases
CleanEx	MM_NT5C1A.
Genevestigator	A3KFX0.
Family and domain databases
InterPro	IPR010394. 5-nucleotidase. [Graphical view]
KO	K01081.
Pfam	PF06189. 5-nucleotidase. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	380069.
SOURCE	Search...

Entry information

Entry name

5NT1A_MOUSE

Accession

Primary (citable) accession number: A3KFX0
Secondary accession number(s): B2RVQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	April 3, 2007
Last modified:	November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program