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Protein

Protein dispatched homolog 3

Gene

Disp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Differentiation, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dispatched homolog 3By similarity
Alternative name(s):
Patched domain-containing protein 2Curated
RND-type protein RNDEu-21 Publication
Gene namesi
Name:Disp3By similarity
Synonyms:Kiaa1337, Ptchd2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444403. Ptchd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 417329ExtracellularSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Topological domaini439 – 4391CytoplasmicSequence analysis
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Topological domaini461 – 4633ExtracellularSequence analysis
Transmembranei464 – 48421HelicalSequence analysisAdd
BLAST
Topological domaini485 – 52844CytoplasmicSequence analysisAdd
BLAST
Transmembranei529 – 54921HelicalSequence analysisAdd
BLAST
Topological domaini550 – 5501ExtracellularSequence analysis
Transmembranei551 – 57121HelicalSequence analysisAdd
BLAST
Topological domaini572 – 684113CytoplasmicSequence analysisAdd
BLAST
Transmembranei685 – 70521HelicalSequence analysisAdd
BLAST
Topological domaini706 – 1137432ExtracellularSequence analysisAdd
BLAST
Transmembranei1138 – 115821HelicalSequence analysisAdd
BLAST
Topological domaini1159 – 11591CytoplasmicSequence analysis
Transmembranei1160 – 118021HelicalSequence analysisAdd
BLAST
Topological domaini1181 – 124666ExtracellularSequence analysisAdd
BLAST
Transmembranei1247 – 126721HelicalSequence analysisAdd
BLAST
Topological domaini1268 – 128114CytoplasmicSequence analysisAdd
BLAST
Transmembranei1282 – 130221HelicalSequence analysisAdd
BLAST
Topological domaini1303 – 13108ExtracellularSequence analysis
Transmembranei1311 – 133121HelicalSequence analysisAdd
BLAST
Topological domaini1332 – 134716CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13471347Protein dispatched homolog 3PRO_0000308330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Glycosylationi976 – 9761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA3KFU9.
PRIDEiA3KFU9.

PTM databases

PhosphoSiteiA3KFU9.

Expressioni

Tissue specificityi

Expressed in brain, retina, testis and thymus (PubMed:19179482).1 Publication

Inductioni

Down-regulated by thyroid hormone T3 (PubMed:19179482).1 Publication

Gene expression databases

CleanExiMM_PTCHD2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini412 – 570159SSDPROSITE-ProRule annotationAdd
BLAST

Domaini

The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake.By similarity

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INZQ. Eukaryota.
ENOG410YJQF. LUCA.
HOGENOMiHOG000115763.
HOVERGENiHBG108304.
InParanoidiA3KFU9.
PhylomeDBiA3KFU9.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A3KFU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSEDDPLLQ DVWLEEEQPE DEACRGIPGP GLQSGAQGCW RRWTLPSRPP
60 70 80 90 100
TLGFWSTLGW AFTNPCCAGL VLFLGCSIPM VLSAFMFLYY PPLDIDISYN
110 120 130 140 150
AFEIRNHEAS QRFDALALAL KSQFGSWGRN RRDLADFTSE TLQRLISEQL
160 170 180 190 200
QQLHLGNHSR PASRAPRSAP RDTVATQTSA ANSSERRRRE APSPEGQVTN
210 220 230 240 250
QSRARRGASR WDYSRTYVSA NTQTHAHWRI ELIFLARGDA ERNIFTSERL
260 270 280 290 300
VTIHEIERKI MDHPGFREFC WKPHEVLKDL PLGSYSYCSP PSSLMTYFFP
310 320 330 340 350
TERGGKIYYD GMGQDLADIR GSLELAMTHP EFYWYVDEGL SVDNLKSSLL
360 370 380 390 400
RSEILFGAPL PNYYSVDDRW EEQRAKFQSF VVTYVAMLAK QSTSKVQVLY
410 420 430 440 450
GGTDLFDYEV RRTFNNDMLL AFISSSCIAA LVYILTSCSV FLSFFGIASI
460 470 480 490 500
GLSCLVALFL YHVVFGIQYL GILNGVAAFV IVGIGVDDVF VFINTYRQAT
510 520 530 540 550
HLEDPQLRMI HTIQTAGKAT FFTSLTTAAA YAANVFSQIP AVHDFGLFMS
560 570 580 590 600
LIVTCCWLAV LFTMPAALGL WSLYMAPLES SCQNSCHQKC GRKSSLHFPG
610 620 630 640 650
DLFTAPERAG GGPAQGPLPY LDDDIPLLNV EDEPASLELG DVSLVSVHCE
660 670 680 690 700
GLQPTPDANS RGQLLAQLQE LLHHWVLWAA VKSRWVIVGL FASILILSLV
710 720 730 740 750
FASRLRPASR APLLFRPDTN IQVLLDLKYN LSAEGISCIT CSGLFQEKPH
760 770 780 790 800
SLQNNVRTSL EKKKRGSGVS WASRTETTAQ ESMSTVYISK VKSKGHPAVY
810 820 830 840 850
RLSLNASLPA PWQAVSPGDG EVPSFQVYRA PFGDFTKKLT ACMSTVGLLQ
860 870 880 890 900
AASPSRKWMV TALACDARRG WKFDFSFYVA TKEQQHTRKL YFAQSHKPPF
910 920 930 940 950
HGRLCVAPPG CLLSSSPDGP TKGFFYVPSD KVPKARISAT FGFNPCVNTG
960 970 980 990 1000
CGKPAVRPLV DTGAMVFVVF GIIGLNRTQQ MDNHVIGDPG SVIYDSSFDL
1010 1020 1030 1040 1050
FKEIGHLCRL CKAIAGNSEL VKPGGAQCLP SGYSISSFLQ MLHPECKELP
1060 1070 1080 1090 1100
EPNLLPGQLS HGAVGVKEGR VQWISMAFES TTYKGKSSFQ TYSDYLRWES
1110 1120 1130 1140 1150
FLRQQLQTFP EGSALHRGFQ TCEHWKQIFM EIIGVQSALY GLVLSLLICV
1160 1170 1180 1190 1200
AAVAVFTTHV LLLLPVLLSI LGIVCLVVTI MYWSGWEMGA VEAISLSILV
1210 1220 1230 1240 1250
GSSVDYCVHL VEGYLLAGEN LPPQLSQDPS SQRQWRTLEA VRHVGVAIVS
1260 1270 1280 1290 1300
SALTTVIATV PLFFCIIAPF AKFGKIVALN TGVSILYTLT VSTALLGIMA
1310 1320 1330 1340
PGSFTRTRTS FLKALGAVLL AGALGLGACL VLLRSGYKIP LPSGATL
Length:1,347
Mass (Da):148,446
Last modified:April 3, 2007 - v1
Checksum:i55EBCFB73F9659E0
GO
Isoform 2 (identifier: A3KFU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     827-839: VYRAPFGDFTKKL → GCFRRRAPPASGW
     840-1347: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):93,488
Checksum:i36C8FEA57AC7F9ED
GO
Isoform 3 (identifier: A3KFU9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     827-1347: Missing.

Note: No experimental confirmation available.
Show »
Length:826
Mass (Da):92,045
Checksum:iA2B1F04BF4684EBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271I → V in BAF32145 (Ref. 1) Curated
Sequence conflicti193 – 1931S → P in BAF32145 (Ref. 1) Curated
Sequence conflicti193 – 1931S → P in BAD32430 (PubMed:15368895).Curated
Sequence conflicti775 – 7751T → P in BAF32145 (Ref. 1) Curated
Sequence conflicti775 – 7751T → P in BAD32430 (PubMed:15368895).Curated
Sequence conflicti951 – 9511C → W in BAD32430 (PubMed:15368895).Curated
Sequence conflicti1018 – 10181S → L in BAF32145 (Ref. 1) Curated
Sequence conflicti1018 – 10181S → L in BAD32430 (PubMed:15368895).Curated
Sequence conflicti1225 – 12273LSQ → QAE in BAF32145 (Ref. 1) Curated
Sequence conflicti1225 – 12273LSQ → QAE in BAD32430 (PubMed:15368895).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei827 – 1347521Missing in isoform 3. 1 PublicationVSP_028967Add
BLAST
Alternative sequencei827 – 83913VYRAP…FTKKL → GCFRRRAPPASGW in isoform 2. 1 PublicationVSP_028968Add
BLAST
Alternative sequencei840 – 1347508Missing in isoform 2. 1 PublicationVSP_028969Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235901 mRNA. Translation: BAF32145.1.
AL645605, AL606919 Genomic DNA. Translation: CAM45930.1.
AL606919, AL645605 Genomic DNA. Translation: CAM46099.1.
BC070441 mRNA. Translation: AAH70441.1.
BC072569 mRNA. Translation: AAH72569.1.
AK173152 mRNA. Translation: BAD32430.1.
CCDSiCCDS38966.1. [A3KFU9-1]
RefSeqiXP_011248557.1. XM_011250255.1.
UniGeneiMm.33873.

Genome annotation databases

GeneIDi242748.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235901 mRNA. Translation: BAF32145.1.
AL645605, AL606919 Genomic DNA. Translation: CAM45930.1.
AL606919, AL645605 Genomic DNA. Translation: CAM46099.1.
BC070441 mRNA. Translation: AAH70441.1.
BC072569 mRNA. Translation: AAH72569.1.
AK173152 mRNA. Translation: BAD32430.1.
CCDSiCCDS38966.1. [A3KFU9-1]
RefSeqiXP_011248557.1. XM_011250255.1.
UniGeneiMm.33873.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038490.

PTM databases

PhosphoSiteiA3KFU9.

Proteomic databases

PaxDbiA3KFU9.
PRIDEiA3KFU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi242748.

Organism-specific databases

CTDi242748.
MGIiMGI:2444403. Ptchd2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410INZQ. Eukaryota.
ENOG410YJQF. LUCA.
HOGENOMiHOG000115763.
HOVERGENiHBG108304.
InParanoidiA3KFU9.
PhylomeDBiA3KFU9.

Miscellaneous databases

PROiA3KFU9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PTCHD2.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the novel RND-type protein in mice."
    Hashimoto S., Yamaguchi A.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Brain and Fetal brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-1347 (ISOFORM 1).
    Tissue: Fetal brain.
  5. "DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism."
    Zikova M., Corlett A., Bendova Z., Pajer P., Bartunek P.
    Mol. Endocrinol. 23:520-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiDISP3_MOUSE
AccessioniPrimary (citable) accession number: A3KFU9
Secondary accession number(s): Q0EEE3
, Q69ZL6, Q6GQX3, Q6NS63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 3, 2007
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.