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Protein

Olfactory receptor 2M5

Gene

OR2M5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2M5
Gene namesi
Name:OR2M5
Synonyms:OR2M5P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19576. OR2M5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871998.

Polymorphism and mutation databases

BioMutaiOR2M5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2M5PRO_0000293719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA3KFT3.
PRIDEiA3KFT3.

PTM databases

PhosphoSiteiA3KFT3.

Expressioni

Gene expression databases

CleanExiHS_OR2M5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355432.

Structurei

3D structure databases

ProteinModelPortaliA3KFT3.
SMRiA3KFT3. Positions 30-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZY. Eukaryota.
ENOG41115SC. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA3KFT3.
KOiK04257.
OMAiWILGSMD.
OrthoDBiEOG7FV3QP.
PhylomeDBiA3KFT3.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3KFT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWENQTFNS DFILLGIFNH SPTHTFLFFL VLAIFSVAFM GNSVMVLLIY
60 70 80 90 100
LDTQLHTPMY FLLSQLFLMD LMLICSTVPK MAFNYLSGSK SISMAGCATQ
110 120 130 140 150
IFFYVSLLGS ECFLLAVMSY DRYIAICHPL RYTNLMRPKI CGLMTAFSWI
160 170 180 190 200
LGSMDAIIDA VATFSFSYCG SREIAHFFCD FPSLLILSCN DTSIFEKVLF
210 220 230 240 250
ICCIVMIVFP VAIIIASYAR VILAVIHMGS GEGRRKAFTT CSSHLMVVGM
260 270 280 290 300
YYGAGLFMYI RPTSDRSPMQ DKLVSVFYTI LTPMLNPLIY SLRNKEVTRA
310
LRKVLGKGKC GE
Length:312
Mass (Da):35,112
Last modified:April 3, 2007 - v1
Checksum:iEDA9160368F2D2CB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441H → N Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064739

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592313 Genomic DNA. Translation: CAM45729.1.
CCDSiCCDS31105.1.
RefSeqiNP_001004690.1. NM_001004690.1.
UniGeneiHs.553580.

Genome annotation databases

EnsembliENST00000366476; ENSP00000355432; ENSG00000162727.
GeneIDi127059.
KEGGihsa:127059.
UCSCiuc010pze.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592313 Genomic DNA. Translation: CAM45729.1.
CCDSiCCDS31105.1.
RefSeqiNP_001004690.1. NM_001004690.1.
UniGeneiHs.553580.

3D structure databases

ProteinModelPortaliA3KFT3.
SMRiA3KFT3. Positions 30-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355432.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiA3KFT3.

Polymorphism and mutation databases

BioMutaiOR2M5.

Proteomic databases

PaxDbiA3KFT3.
PRIDEiA3KFT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366476; ENSP00000355432; ENSG00000162727.
GeneIDi127059.
KEGGihsa:127059.
UCSCiuc010pze.2. human.

Organism-specific databases

CTDi127059.
GeneCardsiOR2M5.
H-InvDBHIX0200030.
HGNCiHGNC:19576. OR2M5.
neXtProtiNX_A3KFT3.
PharmGKBiPA134871998.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZY. Eukaryota.
ENOG41115SC. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA3KFT3.
KOiK04257.
OMAiWILGSMD.
OrthoDBiEOG7FV3QP.
PhylomeDBiA3KFT3.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii127059.
NextBioi81990.
PROiA3KFT3.

Gene expression databases

CleanExiHS_OR2M5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: VARIANT ASN-244.

Entry informationi

Entry nameiOR2M5_HUMAN
AccessioniPrimary (citable) accession number: A3KFT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 3, 2007
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.