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Protein
Submitted name:

Aurora kinase A

Gene

AURKA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiA3KFJ1.

Names & Taxonomyi

Protein namesi
Submitted name:
Aurora kinase AImported
Gene namesi
Name:AURKAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000087586.17.
HGNCiHGNC:11393. AURKA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087586.

PTM / Processingi

Proteomic databases

PaxDbiA3KFJ1.
PeptideAtlasiA3KFJ1.
PRIDEiA3KFJ1.

Expressioni

Gene expression databases

BgeeiENSG00000087586.
ExpressionAtlasiA3KFJ1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA3KFJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 188Protein kinaseInterPro annotationAdd BLAST56

Phylogenomic databases

eggNOGiKOG0580. Eukaryota.
ENOG410XNRB. LUCA.
GeneTreeiENSGT00870000136439.
HOGENOMiHOG000233016.
HOVERGENiHBG108519.

Family and domain databases

InterProiView protein in InterPro
IPR030616. Aur.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PANTHERiPTHR24350. PTHR24350. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Fragment.

A3KFJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP
60 70 80 90 100
SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ
110 120 130 140 150
PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA
160 170 180
REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHL
Length:188
Mass (Da):21,007
Last modified:October 5, 2016 - v8
Checksum:i6A10E69CD54F061A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei188Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121914 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000420474; ENSP00000388073; ENSG00000087586.
UCSCiuc061xwf.1. human.

Similar proteinsi

Entry informationi

Entry nameiA3KFJ1_HUMAN
AccessioniPrimary (citable) accession number: A3KFJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: October 5, 2016
Last modified: September 27, 2017
This is version 88 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported