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Protein

Postacrosomal sheath WW domain-binding protein

Gene

WBP2NL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.1 Publication

GO - Molecular functioni

  • WW domain binding Source: HGNC

GO - Biological processi

  • egg activation Source: HGNC
  • female pronucleus assembly Source: MGI
  • male pronucleus assembly Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Postacrosomal sheath WW domain-binding protein
Alternative name(s):
WW domain-binding protein 2-like
Gene namesi
Name:WBP2NL
Synonyms:PAWP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • perinuclear theca Source: HGNC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Postacrosomal sheath WW domain-binding proteinPRO_0000289126Add
BLAST

Proteomic databases

PaxDbiA3KFF6.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Interactioni

GO - Molecular functioni

  • WW domain binding Source: HGNC

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017533.

Structurei

3D structure databases

ProteinModelPortaliA3KFF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8780GRAMAdd
BLAST
Repeati179 – 18571
Repeati193 – 19972
Repeati207 – 21373
Repeati214 – 22074
Repeati221 – 22775
Repeati228 – 23476
Repeati235 – 24177
Repeati242 – 24878
Repeati249 – 25579
Repeati256 – 262710
Repeati263 – 269711
Repeati270 – 276712

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 2769812 X 7 AA tandem repeat of Y-G-X-P-P-X-GAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1864WW-binding 1
Motifi281 – 2844WW-binding 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 287118Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 GRAM domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiA3KFF6.
OMAiYVQPPPY.
OrthoDBiEOG73805Q.
TreeFamiTF314141.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

A3KFF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNQSHTES RRGALIPSGE SVLKQCEDVD LCFLQKPVES YLFNGTKKGT
60 70 80 90 100
LFLTSYRVVF VTSHLVNDPM LSFMMPFGLM SDCTIEQPIF APNYIKGTIQ
110 120 130 140 150
AAPGGGWEGQ AVFKLSFRKG GAIEFAQLMV KAASAAARGI PLGSVNYWFD
160 170 180 190 200
TSGLYIITVP GAAVCSSQTP CPAYPIVIYG PPPPGYTVQP GEYGTPPEGY
210 220 230 240 250
GAQPGGYGAP PMGYGAPPVG YGVPPGGYGV PPGGYGVPPG GYGAPPGGYG
260 270 280 290 300
VPPGGYGAPP GGYGAPPAGY GAPPAGNEAL PPAYEAPSAG NTAASHRSMT
310
AQQETSLPTT SSS
Length:313
Mass (Da):31,966
Last modified:April 3, 2007 - v1
Checksum:iB700DD904B7D456B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322215 mRNA. Translation: AAQ14855.1.
RefSeqiNP_001075910.1. NM_001082441.1.
UniGeneiBt.96599.

Genome annotation databases

EnsembliENSBTAT00000017533; ENSBTAP00000017533; ENSBTAG00000013174.
GeneIDi523070.
KEGGibta:523070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322215 mRNA. Translation: AAQ14855.1.
RefSeqiNP_001075910.1. NM_001082441.1.
UniGeneiBt.96599.

3D structure databases

ProteinModelPortaliA3KFF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017533.

Proteomic databases

PaxDbiA3KFF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017533; ENSBTAP00000017533; ENSBTAG00000013174.
GeneIDi523070.
KEGGibta:523070.

Organism-specific databases

CTDi164684.

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
GeneTreeiENSGT00530000063718.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiA3KFF6.
OMAiYVQPPPY.
OrthoDBiEOG73805Q.
TreeFamiTF314141.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization."
    Wu A.T.H., Sutovsky P., Manandhar G., Xu W., Katayama M., Day B.N., Park K.-W., Yi Y.-J., Xi Y.W., Prather R.S., Oko R.
    J. Biol. Chem. 282:12164-12175(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MOTIF.
    Tissue: Sperm.

Entry informationi

Entry nameiWBP2L_BOVIN
AccessioniPrimary (citable) accession number: A3KFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 3, 2007
Last modified: June 8, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.