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Protein

Postacrosomal sheath WW domain-binding protein

Gene

WBP2NL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.1 Publication

GO - Molecular functioni

  • WW domain binding Source: HGNC

GO - Biological processi

  • egg activation Source: HGNC
  • female pronucleus assembly Source: MGI
  • male pronucleus assembly Source: HGNC

Names & Taxonomyi

Protein namesi
Recommended name:
Postacrosomal sheath WW domain-binding protein
Alternative name(s):
WW domain-binding protein 2-like
Gene namesi
Name:WBP2NL
Synonyms:PAWP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:36873 WBP2NL

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891261 – 313Postacrosomal sheath WW domain-binding proteinAdd BLAST313

Proteomic databases

PaxDbiA3KFF6
PRIDEiA3KFF6

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSBTAG00000013174

Interactioni

GO - Molecular functioni

  • WW domain binding Source: HGNC

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017533

Structurei

3D structure databases

ProteinModelPortaliA3KFF6
SMRiA3KFF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 87GRAMAdd BLAST80
Repeati179 – 18517
Repeati193 – 19927
Repeati207 – 21337
Repeati214 – 22047
Repeati221 – 22757
Repeati228 – 23467
Repeati235 – 24177
Repeati242 – 24887
Repeati249 – 25597
Repeati256 – 262107
Repeati263 – 269117
Repeati270 – 276127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 27612 X 7 AA tandem repeat of Y-G-X-P-P-X-GAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 186PPxY motif 14
Motifi281 – 284PPxY motif 24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 287Pro-richAdd BLAST118

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3294 Eukaryota
ENOG4111FQW LUCA
GeneTreeiENSGT00530000063718
HOGENOMiHOG000231103
HOVERGENiHBG027489
InParanoidiA3KFF6
KOiK22532
OMAiEGPPVGY
OrthoDBiEOG091G0ICX
TreeFamiTF314141

Family and domain databases

InterProiView protein in InterPro
IPR004182 GRAM
IPR033597 WBP2NL
PANTHERiPTHR31606:SF2 PTHR31606:SF2, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit

Sequencei

Sequence statusi: Complete.

A3KFF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNQSHTES RRGALIPSGE SVLKQCEDVD LCFLQKPVES YLFNGTKKGT
60 70 80 90 100
LFLTSYRVVF VTSHLVNDPM LSFMMPFGLM SDCTIEQPIF APNYIKGTIQ
110 120 130 140 150
AAPGGGWEGQ AVFKLSFRKG GAIEFAQLMV KAASAAARGI PLGSVNYWFD
160 170 180 190 200
TSGLYIITVP GAAVCSSQTP CPAYPIVIYG PPPPGYTVQP GEYGTPPEGY
210 220 230 240 250
GAQPGGYGAP PMGYGAPPVG YGVPPGGYGV PPGGYGVPPG GYGAPPGGYG
260 270 280 290 300
VPPGGYGAPP GGYGAPPAGY GAPPAGNEAL PPAYEAPSAG NTAASHRSMT
310
AQQETSLPTT SSS
Length:313
Mass (Da):31,966
Last modified:April 3, 2007 - v1
Checksum:iB700DD904B7D456B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322215 mRNA Translation: AAQ14855.1
RefSeqiNP_001075910.1, NM_001082441.1
UniGeneiBt.96599

Genome annotation databases

EnsembliENSBTAT00000017533; ENSBTAP00000017533; ENSBTAG00000013174
GeneIDi523070
KEGGibta:523070

Similar proteinsi

Entry informationi

Entry nameiWBP2L_BOVIN
AccessioniPrimary (citable) accession number: A3KFF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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