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A3GI40 (A3GI40_PICST) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding27 – 326NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding50 – 523NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding92 – 943NADP By similarity PIRSR PIRSR000109-3
Region146 – 1483Substrate binding By similarity PIRSR PIRSR000109-2
Region203 – 2042Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site2001Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2071Proton donor By similarity PIRSR PIRSR000109-1
Binding site1201NADP By similarity PIRSR PIRSR000109-3
Binding site1201Substrate By similarity PIRSR PIRSR000109-2
Binding site2081Substrate By similarity PIRSR PIRSR000109-2
Binding site2781Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3051Substrate By similarity PIRSR PIRSR000109-2
Binding site4661Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4721Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A3GI40 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: E29FC0323B684023

FASTA50855,444
        10         20         30         40         50         60 
MTARLAQLSA HLSPTNTLPS GDIGLIGLAV MGQNLILNAA DHGFTVVAYN RTVAKVDEFL 

        70         80         90        100        110        120 
ANEAKGKSII GARSIEELVA NLKRPRRIIL LVKAGKPVDA FIEQLLPHLE KGDIIIDGGN 

       130        140        150        160        170        180 
SHFPDSNRRY EELNDKGILF VGSGVSGGEE GARNGPSLMP GGHKDAWPHI KDIFQSIAAK 

       190        200        210        220        230        240 
SDGEPCCDWV GDAGSGHYVK MVHNGIEYGD MQLICEAYDL LKRVGKFTDK EIGDVFTQWN 

       250        260        270        280        290        300 
KGVLDSFLIE ITRDILYFND PTDGTPLLEK ILDSAGQKGT GKWTAINALD LGMPVTLIGE 

       310        320        330        340        350        360 
AVFSRCLSAL KDERVRASTV LEGPTVSGES PITDRKQFVD DLEQALYASK IISYAQGFML 

       370        380        390        400        410        420 
INEAAKEYGW KLNNPAIALM WRGGCIIRSV FLGEITAAYK ENPDLENLLF HPFFKNAITK 

       430        440        450        460        470        480 
AQSGWRSSIA KAVQYGVPVP AFTTALSFYD GYRSAMLPAN LLQAQRDYFG AHTFKVLPGK 

       490        500 
ENDFLKGDWI HVNWTGKGGN VSASTYDA

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References

[1]"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis."
Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M.
Nat. Biotechnol. 25:319-326(2007) [PubMed: 17334359] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAVQ01000002 Genomic DNA. Translation: EAZ63168.1.
RefSeqXP_001387191.1. XM_001387154.1.

3D structure databases

ProteinModelPortalA3GI40.
SMRA3GI40. Positions 20-495.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3GI40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4851939.
GenomeReviewsGene locus GND1 in contig CM000437_GR.
KEGGpic:PICST_69500.

Phylogenomic databases

eggNOGfuNOG05795.
HOGENOMHBG286913.
OMAPECASAH.
OrthoDBEOG4VDT6Z.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3GI40_PICST
AccessionPrimary (citable) accession number: A3GI40
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info