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Protein

Glutamate decarboxylase

Gene

DCE1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:DCE1Imported
ORF Names:PICST_40180Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
ProteomesiUP000002258 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi4924.PICST_40180.

Structurei

3D structure databases

ProteinModelPortaliA3GHR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
InParanoidiA3GHR1.
KOiK01580.
OMAiRCVSDIH.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A3GHR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSKHIDAE VLETALLKNA VKSKLTKREE YISQYDSEKL VPKYEIPSHS
60 70 80 90 100
SSGELVYKYL SEELTLDGNP TLNLASFVNT SCDDTQLKLI TDNIVKNLAD
110 120 130 140 150
NDEYPSLIDF QQRCISILSN LWHAPTKVDS TGKKVINSIG TATTGSSEAI
160 170 180 190 200
MLAGLALKKR WQEKRKAAGK STENPNIIMA SVAQVALEKF ARYFDVEDRL
210 220 230 240 250
IHVNEESGHL IDISKIKEAV DENTIGIFVI LGSTFTGAFE PVEQISHLLD
260 270 280 290 300
EIEKEKGLDV RIHVDGASGG FVAPFVYPHL KWDFQIPRVD SINTSGHKFG
310 320 330 340 350
LTTAGLGWVI WKDSELLPKS LKFSLDYLGG VEETFGLNFS RAGFPVVLQY
360 370 380 390 400
YNFLTLGKEG YSKIFNSCIS NARLLSNILE KSEYFEVLSV IHKEVSDERA
410 420 430 440 450
AQVYTKVHHV DSKHTKEAIH NEKFEPGLPV VAFRFSKELR ETYPEIPQGI
460 470 480 490 500
FSTLLRNKGY IVPNYHLPPD EGEKEILRVV VRQSLSLNLL EKLVKDSIEA
510 520 530 540 550
VELLIKSCKD VRDVIHAKHT TEEVDKGLVY SLLLSISSGG VEDKKEIQHE
560
QLKQASVNPK HKRRYRATC
Length:569
Mass (Da):63,950
Last modified:June 15, 2009 - v2
Checksum:i866EBC8F0D1A0A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAVQ01000002 Genomic DNA. Translation: EAZ63096.2.
RefSeqiXP_001387119.2. XM_001387082.1.

Genome annotation databases

GeneIDi4851810.
KEGGipic:PICST_40180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAVQ01000002 Genomic DNA. Translation: EAZ63096.2.
RefSeqiXP_001387119.2. XM_001387082.1.

3D structure databases

ProteinModelPortaliA3GHR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4924.PICST_40180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4851810.
KEGGipic:PICST_40180.

Phylogenomic databases

HOGENOMiHOG000070228.
InParanoidiA3GHR1.
KOiK01580.
OMAiRCVSDIH.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545Imported.

Entry informationi

Entry nameiA3GHR1_PICST
AccessioniPrimary (citable) accession number: A3GHR1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 2, 2007
Last sequence update: June 15, 2009
Last modified: March 31, 2015
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.