A3GGU3 (BNA7_PICST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable kynurenine formamidase
EC=3.5.1.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 7
Probable N-formylkynurenine formamidase

Gene names

Name:	BNA7
ORF Names:	PICST_66527

Organism

Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) [Complete proteome]

Taxonomic identifier

322104 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Scheffersomyces

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Probable kynurenine formamidase		PRO_0000361884
Sites
	Active site	33	1	Potential
	Active site	107	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A3GGU3 [UniParc]. Last modified January 19, 2010. Version 2. Checksum: C1E6053C938DD8ED	FASTA	268	31,245
	10 20 30 40 50 60 MSEKIVFYGK EQLQRIRIFN YSESNDKTLI VLHGGGWRDP RNSYNDFEDM ANYILEEKKA 70 80 90 100 110 120 TNINIIGIDY RLSPFIKHPV HLIDVLTAFR YILENYKTGQ LSIVGHSVGA TLLLEILNYV 130 140 150 160 170 180 EIIQTGLEQL ETSEPSIEEL QTLFDFISKN LTFKTMYFLD GIYDVRALLE EYPSYDFFVK 190 200 210 220 230 240 SAFVSTVAIE EASQLSWKQH NEAFKIAVDK YEILHSLEDE LLSLNQPKLF AKYLQDRKIE 250 260 CSFRTGNWGE HEQVYRSQAV SEHVLQNM

References

[1]

"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis." Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M. Nat. Biotechnol. 25:319-326(2007) [PubMed: 17334359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAVQ01000001 Genomic DNA. Translation: EAZ63982.2.
RefSeq	XP_001388005.2. XM_001387968.1.
3D structure databases
ProteinModelPortal	A3GGU3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4851492.
GenomeReviews	Gene locus BNA7 in contig CM000437_GR.
KEGG	pic:PICST_66527.
Phylogenomic databases
eggNOG	fuNOG11665.
HOGENOM	HBG395624.
OrthoDB	EOG4GMZ6M.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
KO	K14263.
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNA7_PICST

Accession

Primary (citable) accession number: A3GGU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	January 19, 2010
Last modified:	December 14, 2011
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program