ID   A3GGJ4_PICST            Unreviewed;       708 AA.
AC   A3GGJ4;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 2.
DT   24-JAN-2024, entry version 93.
DE   SubName: Full=Histone deacetylase {ECO:0000313|EMBL:EAZ63944.2};
DE            EC=3.5.1.48 {ECO:0000313|EMBL:EAZ63944.2};
GN   Name=HOS3 {ECO:0000313|EMBL:EAZ63944.2};
GN   ORFNames=PICST_34373 {ECO:0000313|EMBL:EAZ63944.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:EAZ63944.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:EAZ63944.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAZ63944.2}.
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DR   EMBL; AAVQ01000001; EAZ63944.2; -; Genomic_DNA.
DR   RefSeq; XP_001387967.2; XM_001387930.1.
DR   AlphaFoldDB; A3GGJ4; -.
DR   STRING; 322104.A3GGJ4; -.
DR   GeneID; 4851393; -.
DR   KEGG; pic:PICST_34373; -.
DR   eggNOG; KOG1343; Eukaryota.
DR   HOGENOM; CLU_024583_0_0_1; -.
DR   InParanoid; A3GGJ4; -.
DR   OMA; GTQDICW; -.
DR   OrthoDB; 10780at2759; -.
DR   Proteomes; UP000002258; Chromosome 1.
DR   GO; GO:0047611; F:acetylspermidine deacetylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR47558; HISTONE DEACETYLASE HOS3; 1.
DR   PANTHER; PTHR47558:SF1; HISTONE DEACETYLASE HOS3; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:EAZ63944.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT   DOMAIN          197..441
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   DOMAIN          493..561
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          687..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          438..472
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        687..701
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  80983 MW;  AFABDD13F927138D CRC64;
     MSLQETLSKH NDSEESLISQ FETTLTIRPT ANDDDEVKDI TIDQSTVLHN NTFNYTRDQS
     IVDIDELEEE ELISEQIPKF KTRRRYSLLP AHATKITTKN PGGLDGYYSH IGPKFEHILK
     PSPLIDQSLS NDSDKTLVIL SPYSTEHAFG RKWVTKSYLS TIFERPQRLL ASCIGVASAL
     TMFPFHYKLI NSTRRGSIFA SHVRKIHGKN WPRKLFELCI ESHDKLLNDT LEVPEDWNSG
     DIYVNPRTLN AIEGVIGTIE TAVDSLYGGT NAEDVEDNHN LAFVVIRPPG HHSHACLPSG
     FCLLNNVQIG IEYAFERYGV THCVILDIDL HHGDGSQDIC WERAGFQGDY GQDEDDEIDP
     KSNPRDDYGK RFATFPKVGY FSLHDIKSYP TELGYATKEN IKNASTCIMD HDLNIWNVHL
     QEWSKEEEFY KHYQTKYVAL LNRANQFLNT AKKQYEQQYQ DYLNNLAKYN KFLLKPHLYQ
     GQSLEKPVAP PPFKPLITIS AGFDASEYEN PQMQRHGINV PTSFYATFTH DVVKLAKIHT
     DGRVISFLEG GYSDGALTTG IFSHLIGLNN DEEFLWNPTW GTDQVMKELT KGCKKNWAPY
     KKPQSDITIW ANEVIKLGRA MMPNAILPSN YVYQYQEEEL KAPVNKMVKE LIAHNVNLGE
     ISNSPLKKDP EDERKVMRHT RSYYKKMANA QKQQSIETDS AKHNLPKY
//