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Protein

Mitogen-activated protein kinase

Gene

cgd2_1960

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
ORF Names:cgd2_1960Imported
OrganismiCryptosporidium parvum (strain Iowa II)Imported
Taxonomic identifieri353152 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
Proteomesi
  • UP000006726 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiCryptoDB:cgd2_1960.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi353152.XP_001388215.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OZ6X-ray2.37A/B4-390[»]
ProteinModelPortaliA3FQ79.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3FQ79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 334322Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000246457.
InParanoidiA3FQ79.
KOiK19603.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3FQ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDRVDRHVL RKYELVKKLG KGAYGIVWKS IDRRTGEVVA VKKIFDAFQN
60 70 80 90 100
STDAQRTFRE IMILTELSGH ENIVNLLNVL RADNDRDVYL VFDYMETDLH
110 120 130 140 150
AVIRANILEP VHKQYVVYQL IKVIKYLHSG GLLHRDMKPS NILLNAECHV
160 170 180 190 200
KVADFGLSRS FVNIRRVTNN IPLSINENTE NFDDDQPILT DYVATRWYRA
210 220 230 240 250
PEILLGSTKY TKGIDMWSLG CILGEILCGK PIFPGSSTMN QLERIIGVID
260 270 280 290 300
FPSNEDVESI QSPFAKTMIE SLKEKVEIRQ SNKRDIFTKW KNLLLKINPK
310 320 330 340 350
ADCNEEALDL LDKLLQFNPN KRISANDALK HPFVSIFHNP NEEPNCDHII
360 370 380 390 400
TIPINDNVKH SIDDYRNLVY SEISRRKREL ISNKHQNVQN PNTAVSNPRV
410 420 430 440 450
NRVSGAVEFA TPECNPDNIT SNKSNEPIYS KFQSELQSNK RSSINKNPPA
460 470 480 490 500
DNSKKGGILG NFFSQVYNTF ISGSATNKTT SFGNSPAISN FSNGKVDEKH
510 520 530 540 550
IQQMRSAASY YSSSINNSNP IKKGGGFIGN NLSSTNDNTT KATNSSTKNS
560 570 580 590 600
KYISTGAVIK NANSTFSVST NCGGNSHVYY PRAYMYNNIK HNLPDYSLIP
610 620 630 640 650
NSESSNSLLG KNTSNLKYSN NPELSNQFKL NCHGSNQTSI INLQMQQNRS
660 670 680 690 700
NTSKITYYNE PNIEPNSKLN DMVGRKSTSS GVGVNTLHHP PPFYTSQQNK
710
NVNKNYLYKY
Length:710
Mass (Da):80,116
Last modified:April 3, 2007 - v1
Checksum:i6F15FD562BE58567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000005 Genomic DNA. Translation: EAZ51388.1.
RefSeqiXP_001388215.1. XM_001388178.1.

Genome annotation databases

EnsemblProtistsiEAZ51388; EAZ51388; cgd2_1960.
GeneIDi3373441.
KEGGicpv:cgd2_1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000005 Genomic DNA. Translation: EAZ51388.1.
RefSeqiXP_001388215.1. XM_001388178.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OZ6X-ray2.37A/B4-390[»]
ProteinModelPortaliA3FQ79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353152.XP_001388215.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAZ51388; EAZ51388; cgd2_1960.
GeneIDi3373441.
KEGGicpv:cgd2_1960.

Organism-specific databases

EuPathDBiCryptoDB:cgd2_1960.

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000246457.
InParanoidiA3FQ79.
KOiK19603.

Miscellaneous databases

EvolutionaryTraceiA3FQ79.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA3FQ79_CRYPI
AccessioniPrimary (citable) accession number: A3FQ79
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.