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Protein

Mitogen-activated protein kinase

Gene

cgd2_1960

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
ORF Names:cgd2_1960Imported
OrganismiCryptosporidium parvum (strain Iowa II)Imported
Taxonomic identifieri353152 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
Proteomesi
  • UP000006726 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiCryptoDB:cgd2_1960.

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi353152.XP_001388215.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OZ6X-ray2.37A/B4-390[»]
ProteinModelPortaliA3FQ79.
SMRiA3FQ79.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3FQ79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 334Protein kinaseInterPro annotationAdd BLAST322

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000246457.
InParanoidiA3FQ79.
KOiK19603.
OMAiLICREAL.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

A3FQ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDRVDRHVL RKYELVKKLG KGAYGIVWKS IDRRTGEVVA VKKIFDAFQN
60 70 80 90 100
STDAQRTFRE IMILTELSGH ENIVNLLNVL RADNDRDVYL VFDYMETDLH
110 120 130 140 150
AVIRANILEP VHKQYVVYQL IKVIKYLHSG GLLHRDMKPS NILLNAECHV
160 170 180 190 200
KVADFGLSRS FVNIRRVTNN IPLSINENTE NFDDDQPILT DYVATRWYRA
210 220 230 240 250
PEILLGSTKY TKGIDMWSLG CILGEILCGK PIFPGSSTMN QLERIIGVID
260 270 280 290 300
FPSNEDVESI QSPFAKTMIE SLKEKVEIRQ SNKRDIFTKW KNLLLKINPK
310 320 330 340 350
ADCNEEALDL LDKLLQFNPN KRISANDALK HPFVSIFHNP NEEPNCDHII
360 370 380 390 400
TIPINDNVKH SIDDYRNLVY SEISRRKREL ISNKHQNVQN PNTAVSNPRV
410 420 430 440 450
NRVSGAVEFA TPECNPDNIT SNKSNEPIYS KFQSELQSNK RSSINKNPPA
460 470 480 490 500
DNSKKGGILG NFFSQVYNTF ISGSATNKTT SFGNSPAISN FSNGKVDEKH
510 520 530 540 550
IQQMRSAASY YSSSINNSNP IKKGGGFIGN NLSSTNDNTT KATNSSTKNS
560 570 580 590 600
KYISTGAVIK NANSTFSVST NCGGNSHVYY PRAYMYNNIK HNLPDYSLIP
610 620 630 640 650
NSESSNSLLG KNTSNLKYSN NPELSNQFKL NCHGSNQTSI INLQMQQNRS
660 670 680 690 700
NTSKITYYNE PNIEPNSKLN DMVGRKSTSS GVGVNTLHHP PPFYTSQQNK
710
NVNKNYLYKY
Length:710
Mass (Da):80,116
Last modified:April 3, 2007 - v1
Checksum:i6F15FD562BE58567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000005 Genomic DNA. Translation: EAZ51388.1.
RefSeqiXP_001388215.1. XM_001388178.1.

Genome annotation databases

EnsemblProtistsiEAZ51388; EAZ51388; cgd2_1960.
GeneIDi3373441.
KEGGicpv:cgd2_1960.

Similar proteinsi

Entry informationi

Entry nameiA3FQ79_CRYPI
AccessioniPrimary (citable) accession number: A3FQ79
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported