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Protein

Genome polyprotein

Gene

NS3

Organism
Hepatitis C virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase
Biological processViral RNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
Gene namesi
Name:NS3Imported
OrganismiHepatitis C virusImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

VirionSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4893.

Structurei

3D structure databases

SMRiA3EZI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 343Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini335 – 512Helicase C-terminalInterPro annotationAdd BLAST178

Family and domain databases

InterProiView protein in InterPro
IPR011492. DEAD_Flavivir.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR009003. Peptidase_S1_PA.
IPR004109. Peptidase_S29.
PfamiView protein in Pfam
PF07652. Flavi_DEAD. 1 hit.
PF02907. Peptidase_S29. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Fragment.

A3EZI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APITAYAQQT RGLLGCIITS LTGRDKNQVE GEVQIVSTAA QTFLATCING
60 70 80 90 100
VCWTVYHGAG TRTIASSKGP VIQMYTNVDQ DLVGWPAPQG ARSLTPCTCG
110 120 130 140 150
SSDLYLVTRH ADVIPVRRRG DGRGSLLSPR PISYLKGSSG GPLLCPAGHA
160 170 180 190 200
VGIFRAAVCT RGVAKAVDFI PVEGLETTMR SPVFSDNSSP PAVPQSYQVA
210 220 230 240 250
HLHAPTGSGK STKVPAAYAA QGYKVLVLNP SVAATLGFGA YMSKAHGIDP
260 270 280 290 300
NIRTGVRTIT TGSPITYSTY GKFLADGGCS GGAYDIIICD ECHSTDATSI
310 320 330 340 350
LGIGTVLDQA ETAGARLTVL ATATPPGSVT VPHPNIEEVA LSTTGEIPFY
360 370 380 390 400
GKAIPLEAIK GGRHLIFCHS KKKCDELAAK LVALGVNAVA YYRGLDVSVI
410 420 430 440 450
PASGDVVVVA TDALMTGFTG DFDSVIDCNT CVTQTVDFSL DPTFTIETTT
460 470 480 490 500
LPQDAVSRTQ RRGRTGRGKP GIYRFVTPGE RPSGMFDSSV LCECYDAGCA
510 520 530 540 550
WYELTPAETT VRLRAYMNTP GLPVCQDHLE FWEGVFTGLT HIDAHFLSQT
560 570 580 590 600
KQSGENLPYL VAYQATVCAR AQAPPPSWDQ MWKCLIRLKP TLHGPTPLLY
610 620 630
RLGAVQNEIT LTHPITKYIM TCMSADLEVV T
Length:631
Mass (Da):67,062
Last modified:March 20, 2007 - v1
Checksum:iB6A0867B8318D75D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei631Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF173649 Genomic RNA. Translation: ABN45872.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA3EZI9_9HEPC
AccessioniPrimary (citable) accession number: A3EZI9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 10, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)