Reviewed, UniProtKB/Swiss-Prot A3EZ55 (HOG1_WALIC)

Names and origin

Protein names

Recommended name:
    Mitogen-activated protein kinase HOG1
      Short name=MAP kinase HOG1
    EC=2.7.11.24
Alternative name(s):
    WiHog1

Gene names

Name:

HOG1

Organism

Wallemia ichthyophaga

Taxonomic identifier

245174 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Basidiomycota incertae sedis › Wallemiomycetes › Wallemiales › Wallemiales incertae sedis › Wallemia

Protein attributes

Sequence length	278 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated by tyrosine and threonine phosphorylation By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Domain	The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modification	Dually phosphorylated on Thr-105 and Tyr-107, which activates the enzyme By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›278	›278	Mitogen-activated protein kinase HOG1		PRO_0000289706
Regions
	Domain	‹1 – 233	›233	Protein kinase
	Motif	105 – 107	3	TXY
Amino acid modifications
	Modified residue	105	1	Phosphothreonine By similarity
	Modified residue	107	1	Phosphotyrosine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	278	1

Sequences

	Sequence		Length	Mass (Da)
	A3EZ55-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 21F19BBD462C0042	FASTA	278	32,131
	10 20 30 40 50 60 NSLVIKHLRH ENIISLLDVF ISPGEDIYFI TELLGTDLHR LLSSRPLERQ FVQYFLYQML 70 80 90 100 110 120 RALKFVHPAG VVHRDLKPSN ILINENCDLK ICDFGLARLQ DPQMTGYVST RYYKAPEIML 130 140 150 160 170 180 TWQEYDSAVD IWSVGCIFAE MIDGRPIFPG KDHVHQLTVI TELLGSPPED VINTITSENT 190 200 210 220 230 240 RRFVDALPKR HKISFADRFP NANAEEIDLL EKMLDFNPKK RITAADALAH PYLAPYHDPE 250 260 270 DEPTANERFD WSFNDADLPT DQWKVMMYCR DLNRIPAA

References

[1]	"Partial genomic DNA sequence of a putative MAP kinase HOG1 (WiHog1p) from Wallemia ichthyophaga." Vaupotic T., Plemenitas A. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: EXF-994.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF158006 Genomic DNA. Translation: ABN54705.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008352. MAPK_p38. IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01773. P38MAPKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOG1_WALIC

Accession

Primary (citable) accession number: A3EZ55

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 20, 2007
Last modified:	September 22, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)