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A3EZ55

- HOG1A_WALI9

UniProt

A3EZ55 - HOG1A_WALI9

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Protein
Mitogen-activated protein kinase HOG1A
Gene
HOG1A, J056_003708
Organism
Wallemia ichthyophaga (strain EXF-994 / CBS 113033)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531ATP By similarity
Active sitei145 – 1451Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 389ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1A (EC:2.7.11.24)
Short name:
MAP kinase HOG1A
Alternative name(s):
WiHog1A
Gene namesi
Name:HOG1A
ORF Names:J056_003708
OrganismiWallemia ichthyophaga (strain EXF-994 / CBS 113033)
Taxonomic identifieri1299270 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaBasidiomycota incertae sedisWallemiomycetesWallemialesWallemiales incertae sedisWallemia
ProteomesiUP000014064: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Mitogen-activated protein kinase HOG1A
PRO_0000289706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine By similarity
Modified residuei177 – 1771Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated. Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme By similarity. Rapidly dephosphorylated upon either hypo- or hyperosmotic shock.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By hyperosmotic and hypo-osmotic stress. Less induced than isoform HOG1B under the same conditions.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA3EZ55.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 303280Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1773TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3EZ55-1 [UniParc]FASTAAdd to Basket

« Hide

MSQEDSSFVK LSVFGNIFQV TTRYTDLQPV GMGAFGLLCS STDQKSGGPV    50
AIKKVMKPFS APVLAKRTYR ELKLLKHLRH ENIISLLDVF ISPGEDIYFI 100
TELLGTDLHR LLSSRPLERQ FVQYFLYQML RALKFVHPAG VVHRDLKPSN 150
ILINENCDLK ICDFGLARLQ DPQMTGYVST RYYRAPEIML TWQEYDSAVD 200
IWSVGCIFAE MIDGRPIFPG KDHVHQLTVI TELLGSPPED VINTITSENT 250
RRFVDALPKR HKISFADRFP NANAEEIDLL EKMLDFNPKK RITAADALAH 300
PYLAPYHDPE DEPTANERFD WSFNDADLPT DQWKVMMYSE ILDFHNVDVK 350
SEKDMTPSTT TAGAH 365
Length:365
Mass (Da):41,633
Last modified:May 14, 2014 - v2
Checksum:i387C630BB77C6734
GO

Sequence cautioni

The sequence ABN54705.1 differs from that shown. Reason: Contains vector sequence in the N- and C-terminal part.
The sequence EOR02032.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841R → K in ABN54705. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX573532 Genomic DNA. Translation: AGG39582.1.
KE007228 Genomic DNA. Translation: EOR02032.1. Sequence problems.
EF158006 Genomic DNA. Translation: ABN54705.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JX573532 Genomic DNA. Translation: AGG39582.1 .
KE007228 Genomic DNA. Translation: EOR02032.1 . Sequence problems.
EF158006 Genomic DNA. Translation: ABN54705.1 . Sequence problems.

3D structure databases

ProteinModelPortali A3EZ55.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01773. P38MAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: identification and characterisation of MAP kinases WiHog1A and WiHog1B."
    Konte T., Plemenitas A.
    Extremophiles 17:623-636(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, PHOSPHORYLATION, INDUCTION.
    Strain: EXF-994 / CBS 113033.
  2. "Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: haloadaptations present and absent."
    Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.
    BMC Genomics 14:617-617(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EXF-994 / CBS 113033.
  3. "The MAP kinase HwHog1 from the halophilic black yeast Hortaea werneckii: coping with stresses in solar salterns."
    Lenassi M., Vaupotic T., Gunde-Cimerman N., Plemenitas A.
    Saline Syst. 3:3-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-338.
    Strain: EXF-994 / CBS 113033.

Entry informationi

Entry nameiHOG1A_WALI9
AccessioniPrimary (citable) accession number: A3EZ55
Secondary accession number(s): M1S3C2, R9AIJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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