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A3EZ53 (HOG1_WALMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase HOG1

Short name=MAP kinase HOG1
EC=2.7.11.24
Alternative name(s):
WmHog1
Gene names
Name:HOG1
OrganismWallemia muriae
Taxonomic identifier245175 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaBasidiomycota incertae sedisWallemiomycetesWallemialesWallemiales incertae sedisWallemia

Protein attributes

Sequence length278 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-106 and Tyr-108, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›278›278Mitogen-activated protein kinase HOG1
PRO_0000289707

Regions

Domain‹1 – 234›234Protein kinase
Motif106 – 1083TXY

Amino acid modifications

Modified residue1061Phosphothreonine By similarity
Modified residue1081Phosphotyrosine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2781

Sequences

Sequence LengthMass (Da)Tools
A3EZ53 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 3129735C9C254156

FASTA27832,283
        10         20         30         40         50         60 
GRGNSIKHLR HENIISLLDV FISPGEDIYF ITELLGTDLH RLLSSRPLER QFVQYFLYQM 

        70         80         90        100        110        120 
LRALKFVHPA GVVHRDLKPS NILINENCDL KICDFGLARL QDPQMTGYVS TRYYRAPEIM 

       130        140        150        160        170        180 
LTWQEYDSAV DIWSIGCIFA EMIDGRPIFP GKDHVHQLTV ITELLGSPPE DVINTITSEN 

       190        200        210        220        230        240 
TRRFVDALPK REKIPFQQRF PNANEEEIDL LEKMLDFNPK ERITAADAIQ HPYLAPYHDP 

       250        260        270 
SDEPVANERF DWSFNDADLP VDQWKVMMYS EILITSEF 

« Hide

References

[1]"Partial genomic DNA sequence of a putative MAP kinase HOG1 (WmHog1p) from Wallemia muriae."
Vaupotic T., Plemenitas A.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MZKI-B952.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF158004 Genomic DNA. Translation: ABN54703.1.

3D structure databases

ProteinModelPortalA3EZ53.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA3EZ53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_WALMU
AccessionPrimary (citable) accession number: A3EZ53
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families