Reviewed, UniProtKB/Swiss-Prot A3EZ53 (HOG1_WALMU)

Names and origin

Protein names

Recommended name:
    Mitogen-activated protein kinase HOG1
      Short name=MAP kinase HOG1
    EC=2.7.11.24
Alternative name(s):
    WmHog1

Gene names

Name:

HOG1

Organism

Wallemia muriae

Taxonomic identifier

245175 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Basidiomycota incertae sedis › Wallemiomycetes › Wallemiales › Wallemiales incertae sedis › Wallemia

Protein attributes

Sequence length	278 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated by tyrosine and threonine phosphorylation By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Domain	The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modification	Dually phosphorylated on Thr-106 and Tyr-108, which activates the enzyme By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›278	›278	Mitogen-activated protein kinase HOG1		PRO_0000289707
Regions
	Domain	‹1 – 234	›234	Protein kinase
	Motif	106 – 108	3	TXY
Amino acid modifications
	Modified residue	106	1	Phosphothreonine By similarity
	Modified residue	108	1	Phosphotyrosine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	278	1

Sequences

	Sequence		Length	Mass (Da)
	A3EZ53-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 3129735C9C254156	FASTA	278	32,283
	10 20 30 40 50 60 GRGNSIKHLR HENIISLLDV FISPGEDIYF ITELLGTDLH RLLSSRPLER QFVQYFLYQM 70 80 90 100 110 120 LRALKFVHPA GVVHRDLKPS NILINENCDL KICDFGLARL QDPQMTGYVS TRYYRAPEIM 130 140 150 160 170 180 LTWQEYDSAV DIWSIGCIFA EMIDGRPIFP GKDHVHQLTV ITELLGSPPE DVINTITSEN 190 200 210 220 230 240 TRRFVDALPK REKIPFQQRF PNANEEEIDL LEKMLDFNPK ERITAADAIQ HPYLAPYHDP 250 260 270 SDEPVANERF DWSFNDADLP VDQWKVMMYS EILITSEF

References

[1]	"Partial genomic DNA sequence of a putative MAP kinase HOG1 (WmHog1p) from Wallemia muriae." Vaupotic T., Plemenitas A. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MZKI-B952.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF158004 Genomic DNA. Translation: ABN54703.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008352. MAPK_p38. IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01773. P38MAPKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOG1_WALMU

Accession

Primary (citable) accession number: A3EZ53

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 20, 2007
Last modified:	September 22, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)