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Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Wallemia muriae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Alternative name(s):
WmHog1
Gene namesi
Name:HOG1
OrganismiWallemia muriae
Taxonomic identifieri245175 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaWallemiomycetesWallemialesWallemiales incertae sedisWallemia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000289707‹1 – ›278Mitogen-activated protein kinase HOG1Add BLAST›278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphothreonineBy similarity1
Modified residuei108PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-106 and Tyr-108, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA3EZ53

Structurei

3D structure databases

ProteinModelPortaliA3EZ53
SMRiA3EZ53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 234Protein kinasePROSITE-ProRule annotationAdd BLAST›234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi106 – 108TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR008352 MAPK_p38-like
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01773 P38MAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Fragment.

A3EZ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRGNSIKHLR HENIISLLDV FISPGEDIYF ITELLGTDLH RLLSSRPLER
60 70 80 90 100
QFVQYFLYQM LRALKFVHPA GVVHRDLKPS NILINENCDL KICDFGLARL
110 120 130 140 150
QDPQMTGYVS TRYYRAPEIM LTWQEYDSAV DIWSIGCIFA EMIDGRPIFP
160 170 180 190 200
GKDHVHQLTV ITELLGSPPE DVINTITSEN TRRFVDALPK REKIPFQQRF
210 220 230 240 250
PNANEEEIDL LEKMLDFNPK ERITAADAIQ HPYLAPYHDP SDEPVANERF
260 270
DWSFNDADLP VDQWKVMMYS EILITSEF
Length:278
Mass (Da):32,283
Last modified:March 20, 2007 - v1
Checksum:i3129735C9C254156
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2781

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF158004 Genomic DNA Translation: ABN54703.1

Similar proteinsi

Entry informationi

Entry nameiHOG1_WALMU
AccessioniPrimary (citable) accession number: A3EZ53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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