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A3EZ53

- HOG1_WALMU

UniProt

A3EZ53 - HOG1_WALMU

Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Wallemia muriae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
    Short name:
    MAP kinase HOG1
    Alternative name(s):
    WmHog1
    Gene namesi
    Name:HOG1
    OrganismiWallemia muriae
    Taxonomic identifieri245175 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaBasidiomycota incertae sedisWallemiomycetesWallemialesWallemiales incertae sedisWallemia

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›278›278Mitogen-activated protein kinase HOG1PRO_0000289707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei106 – 1061PhosphothreonineBy similarity
    Modified residuei108 – 1081PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-106 and Tyr-108, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA3EZ53.

    Structurei

    3D structure databases

    ProteinModelPortaliA3EZ53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 234›234Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi106 – 1083TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01773. P38MAPKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A3EZ53-1 [UniParc]FASTAAdd to Basket

    « Hide

    GRGNSIKHLR HENIISLLDV FISPGEDIYF ITELLGTDLH RLLSSRPLER    50
    QFVQYFLYQM LRALKFVHPA GVVHRDLKPS NILINENCDL KICDFGLARL 100
    QDPQMTGYVS TRYYRAPEIM LTWQEYDSAV DIWSIGCIFA EMIDGRPIFP 150
    GKDHVHQLTV ITELLGSPPE DVINTITSEN TRRFVDALPK REKIPFQQRF 200
    PNANEEEIDL LEKMLDFNPK ERITAADAIQ HPYLAPYHDP SDEPVANERF 250
    DWSFNDADLP VDQWKVMMYS EILITSEF 278
    Length:278
    Mass (Da):32,283
    Last modified:March 20, 2007 - v1
    Checksum:i3129735C9C254156
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei278 – 2781

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF158004 Genomic DNA. Translation: ABN54703.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF158004 Genomic DNA. Translation: ABN54703.1 .

    3D structure databases

    ProteinModelPortali A3EZ53.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A3EZ53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01773. P38MAPKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Partial genomic DNA sequence of a putative MAP kinase HOG1 (WmHog1p) from Wallemia muriae."
      Vaupotic T., Plemenitas A.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MZKI-B952.

    Entry informationi

    Entry nameiHOG1_WALMU
    AccessioniPrimary (citable) accession number: A3EZ53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3