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A3EY21

- A3EY21_HUMAN

UniProt

A3EY21 - A3EY21_HUMAN

Protein
Submitted name:

Cardiac sodium channel alpha subunit

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. voltage-gated sodium channel activity involved in SA node cell action potential Source: Ensembl

    GO - Biological processi

    1. cardiac ventricle development Source: Ensembl
    2. regulation of cardiac muscle cell contraction Source: Ensembl
    3. regulation of heart rate by cardiac conduction Source: Ensembl
    4. response to organic cyclic compound Source: Ensembl

    Keywords - Molecular functioni

    Ion channelImported

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cardiac sodium channel alpha subunitImported
    Submitted name:
    Sodium channel protein type 5 subunit alphaImported
    Gene namesi
    Name:SCN5AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10593. SCN5A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. intercalated disc Source: Ensembl
    3. sodium channel complex Source: Ensembl
    4. T-tubule Source: Ensembl

    Sequencei

    Sequence statusi: Fragment.

    A3EY21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE   50
    APRPQLDLQA SKKLP 65
    Length:65
    Mass (Da):7,358
    Last modified:March 20, 2007 - v1
    Checksum:i72F910AA67CE583F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei65 – 651Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006241 Genomic DNA. No translation available.
    EF092295 mRNA. Translation: ABN50064.1.
    UniGeneiHs.517898.

    Genome annotation databases

    EnsembliENST00000327956; ENSP00000333674; ENSG00000183873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006241 Genomic DNA. No translation available.
    EF092295 mRNA. Translation: ABN50064.1 .
    UniGenei Hs.517898.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327956 ; ENSP00000333674 ; ENSG00000183873 .

    Organism-specific databases

    HGNCi HGNC:10593. SCN5A.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35461422.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Heart failure is associated with abnormal C-terminus splicing variants in cardiac sodium channel."
      Shang L.L., Dudley S.C. Jr.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeartImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA3EY21_HUMAN
    AccessioniPrimary (citable) accession number: A3EY21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3