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A3EY21

- A3EY21_HUMAN

UniProt

A3EY21 - A3EY21_HUMAN

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Protein
Submitted name:

Cardiac sodium channel alpha subunit

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. voltage-gated sodium channel activity involved in SA node cell action potential Source: Ensembl

GO - Biological processi

  1. cardiac ventricle development Source: Ensembl
  2. regulation of cardiac muscle cell contraction Source: Ensembl
  3. regulation of heart rate by cardiac conduction Source: Ensembl
  4. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channelImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cardiac sodium channel alpha subunitImported
Submitted name:
Sodium channel protein type 5 subunit alphaImported
Gene namesi
Name:SCN5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10593. SCN5A.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. intercalated disc Source: Ensembl
  3. sodium channel complex Source: Ensembl
  4. T-tubule Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiA3EY21. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA3EY21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118827.

Sequencei

Sequence statusi: Fragment.

A3EY21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE
60
APRPQLDLQA SKKLP
Length:65
Mass (Da):7,358
Last modified:March 20, 2007 - v1
Checksum:i72F910AA67CE583F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei65 – 651Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006241 Genomic DNA. No translation available.
EF092295 mRNA. Translation: ABN50064.1.
UniGeneiHs.517898.

Genome annotation databases

EnsembliENST00000327956; ENSP00000333674; ENSG00000183873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006241 Genomic DNA. No translation available.
EF092295 mRNA. Translation: ABN50064.1 .
UniGenei Hs.517898.

3D structure databases

ProteinModelPortali A3EY21.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327956 ; ENSP00000333674 ; ENSG00000183873 .

Organism-specific databases

HGNCi HGNC:10593. SCN5A.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118827.

Miscellaneous databases

NextBioi 35461422.

Gene expression databases

ExpressionAtlasi A3EY21. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Heart failure is associated with abnormal C-terminus splicing variants in cardiac sodium channel."
    Shang L.L., Dudley S.C. Jr.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA3EY21_HUMAN
AccessioniPrimary (citable) accession number: A3EY21
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3