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A3EXH0

- NCAP_BCHK9

UniProt

A3EXH0 - NCAP_BCHK9

Protein

Nucleoprotein

Gene

N

Organism
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    NC
    Short name:
    Protein N
    Gene namesi
    Name:N
    ORF Names:6
    OrganismiBat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
    Taxonomic identifieri694006 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
    Virus hostiRousettus leschenaultii (Leschenault's rousette) [TaxID: 9408]
    ProteomesiUP000006576: Genome

    Subcellular locationi

    Virion By similarity. Host cytoplasmhost perinuclear region By similarity. Host endoplasmic reticulum-Golgi intermediate compartment By similarity. Host Golgi apparatus By similarity
    Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding By similarity.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
    2. host cell Golgi apparatus Source: UniProtKB-SubCell
    3. host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. ribonucleoprotein complex Source: UniProtKB-KW
    5. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cytoplasm, Host Golgi apparatus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468NucleoproteinPRO_0000291327Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA3EXH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 193136RNA-bindingBy similarityAdd
    BLAST
    Regioni270 – 378109DimerizationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi189 – 21729Ser-richAdd
    BLAST
    Compositional biasi314 – 3174Poly-Ala
    Compositional biasi381 – 3877Poly-Lys

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001218. Corona_nucleocap.
    [Graphical view]
    PfamiPF00937. Corona_nucleoca. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003888. Corona_nucleocap. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3EXH0-1 [UniParc]FASTAAdd to Basket

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    MSGRNRSRSG TPSPKVTFKQ ESDGSDSESE RRNGNRNGAR PKNNNSRGSA    50
    PKPEKPKAAP PQNVSWFAPL VQTGKAELRF PRGEGVPVSQ GVDSTYEHGY 100
    WLRTQRSFQK GGKQVLANPR WYFYYTGTGR FGDLRFGTKN PDIVWVGQEG 150
    ANINRLGDMG TRNPSNDGAI PVQLAGGIPK GFYAEGRGSR GNSRSSSRNS 200
    SRASSRGNSR ASSRGASPGR PAANPSTEPW MAYLVQKLER LESQVSGTKP 250
    ATKNPVQVTK NEAAANAKKL RHKRTAHKGS GVTVNYGRRG PGDLEGNFGD 300
    REMIKLGTDD PRFAAAAQMA PNVSSFLFMS HLSTRDEDDA LWLHYKGAIK 350
    LPKDDPNYEQ WTKILAENLN AYKDFPPTEP KKDKKKKEET AQDTVIFEDA 400
    STGTDQTVVK VWVKDQDAQT DDEWLGGDET VYEDEDDRPK TQRRHKKRGS 450
    TASRVTIADP TNAGAERS 468
    Length:468
    Mass (Da):51,547
    Last modified:March 20, 2007 - v1
    Checksum:i188D262F3D9FAA0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF065513 Genomic RNA. Translation: ABN10915.1.
    RefSeqiYP_001039975.1. NC_009021.1.

    Genome annotation databases

    GeneIDi4836017.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF065513 Genomic RNA. Translation: ABN10915.1 .
    RefSeqi YP_001039975.1. NC_009021.1.

    3D structure databases

    ProteinModelPortali A3EXH0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4836017.

    Family and domain databases

    InterProi IPR001218. Corona_nucleocap.
    [Graphical view ]
    Pfami PF00937. Corona_nucleoca. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003888. Corona_nucleocap. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features."
      Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L., Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H., Zheng B.-J., Yuen K.-Y.
      J. Virol. 81:1574-1585(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate HKU9-1.

    Entry informationi

    Entry nameiNCAP_BCHK9
    AccessioniPrimary (citable) accession number: A3EXH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3