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A3EXH0

- NCAP_BCHK9

UniProt

A3EXH0 - NCAP_BCHK9

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Protein

Nucleoprotein

Gene
N, 6
Organism
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NC
Short name:
Protein N
Gene namesi
Name:N
ORF Names:6
OrganismiBat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Taxonomic identifieri694006 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiRousettus leschenaultii (Leschenault's rousette) [TaxID: 9408]
ProteomesiUP000006576: Genome

Subcellular locationi

Virion By similarity. Host cytoplasmhost perinuclear region By similarity. Host endoplasmic reticulum-Golgi intermediate compartment By similarity. Host Golgi apparatus By similarity
Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding By similarity.

GO - Cellular componenti

  1. host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  2. host cell Golgi apparatus Source: UniProtKB-SubCell
  3. host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
  4. ribonucleoprotein complex Source: UniProtKB-KW
  5. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468NucleoproteinPRO_0000291327Add
BLAST

Interactioni

Subunit structurei

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein By similarity.

Structurei

3D structure databases

ProteinModelPortaliA3EXH0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 193136RNA-binding By similarityAdd
BLAST
Regioni270 – 378109Dimerization By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 21729Ser-richAdd
BLAST
Compositional biasi314 – 3174Poly-Ala
Compositional biasi381 – 3877Poly-Lys

Sequence similaritiesi

Family and domain databases

InterProiIPR001218. Corona_nucleocap.
[Graphical view]
PfamiPF00937. Corona_nucleoca. 1 hit.
[Graphical view]
PIRSFiPIRSF003888. Corona_nucleocap. 1 hit.

Sequencei

Sequence statusi: Complete.

A3EXH0-1 [UniParc]FASTAAdd to Basket

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MSGRNRSRSG TPSPKVTFKQ ESDGSDSESE RRNGNRNGAR PKNNNSRGSA    50
PKPEKPKAAP PQNVSWFAPL VQTGKAELRF PRGEGVPVSQ GVDSTYEHGY 100
WLRTQRSFQK GGKQVLANPR WYFYYTGTGR FGDLRFGTKN PDIVWVGQEG 150
ANINRLGDMG TRNPSNDGAI PVQLAGGIPK GFYAEGRGSR GNSRSSSRNS 200
SRASSRGNSR ASSRGASPGR PAANPSTEPW MAYLVQKLER LESQVSGTKP 250
ATKNPVQVTK NEAAANAKKL RHKRTAHKGS GVTVNYGRRG PGDLEGNFGD 300
REMIKLGTDD PRFAAAAQMA PNVSSFLFMS HLSTRDEDDA LWLHYKGAIK 350
LPKDDPNYEQ WTKILAENLN AYKDFPPTEP KKDKKKKEET AQDTVIFEDA 400
STGTDQTVVK VWVKDQDAQT DDEWLGGDET VYEDEDDRPK TQRRHKKRGS 450
TASRVTIADP TNAGAERS 468
Length:468
Mass (Da):51,547
Last modified:March 20, 2007 - v1
Checksum:i188D262F3D9FAA0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF065513 Genomic RNA. Translation: ABN10915.1.
RefSeqiYP_001039975.1. NC_009021.1.

Genome annotation databases

GeneIDi4836017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF065513 Genomic RNA. Translation: ABN10915.1 .
RefSeqi YP_001039975.1. NC_009021.1.

3D structure databases

ProteinModelPortali A3EXH0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4836017.

Family and domain databases

InterProi IPR001218. Corona_nucleocap.
[Graphical view ]
Pfami PF00937. Corona_nucleoca. 1 hit.
[Graphical view ]
PIRSFi PIRSF003888. Corona_nucleocap. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features."
    Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L., Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H., Zheng B.-J., Yuen K.-Y.
    J. Virol. 81:1574-1585(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HKU9-1.

Entry informationi

Entry nameiNCAP_BCHK9
AccessioniPrimary (citable) accession number: A3EXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: October 16, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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