Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A3EXH0 (NCAP_BCHK9) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=NC
Short name=Protein N
Gene names
Name:N
ORF Names:6
OrganismBat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) [Complete proteome]
Taxonomic identifier694006 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostRousettus leschenaultii (Leschenault's rousette) [TaxID: 9408]

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication By similarity.

Subunit structure

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein By similarity.

Subcellular location

Virion By similarity. Host cytoplasmhost perinuclear region By similarity. Host endoplasmic reticulum-Golgi intermediate compartment By similarity. Host Golgi apparatus By similarity. Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding By similarity.

Sequence similarities

Belongs to the coronavirus group 2b/2c/2d nucleocapsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Nucleoprotein
PRO_0000291327

Regions

Region58 – 193136RNA-binding By similarity
Region270 – 378109Dimerization By similarity
Compositional bias189 – 21729Ser-rich
Compositional bias314 – 3174Poly-Ala
Compositional bias381 – 3877Poly-Lys

Sequences

Sequence LengthMass (Da)Tools
A3EXH0 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 188D262F3D9FAA0E

FASTA46851,547
        10         20         30         40         50         60 
MSGRNRSRSG TPSPKVTFKQ ESDGSDSESE RRNGNRNGAR PKNNNSRGSA PKPEKPKAAP 

        70         80         90        100        110        120 
PQNVSWFAPL VQTGKAELRF PRGEGVPVSQ GVDSTYEHGY WLRTQRSFQK GGKQVLANPR 

       130        140        150        160        170        180 
WYFYYTGTGR FGDLRFGTKN PDIVWVGQEG ANINRLGDMG TRNPSNDGAI PVQLAGGIPK 

       190        200        210        220        230        240 
GFYAEGRGSR GNSRSSSRNS SRASSRGNSR ASSRGASPGR PAANPSTEPW MAYLVQKLER 

       250        260        270        280        290        300 
LESQVSGTKP ATKNPVQVTK NEAAANAKKL RHKRTAHKGS GVTVNYGRRG PGDLEGNFGD 

       310        320        330        340        350        360 
REMIKLGTDD PRFAAAAQMA PNVSSFLFMS HLSTRDEDDA LWLHYKGAIK LPKDDPNYEQ 

       370        380        390        400        410        420 
WTKILAENLN AYKDFPPTEP KKDKKKKEET AQDTVIFEDA STGTDQTVVK VWVKDQDAQT 

       430        440        450        460 
DDEWLGGDET VYEDEDDRPK TQRRHKKRGS TASRVTIADP TNAGAERS 

« Hide

References

[1]"Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features."
Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L., Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H., Zheng B.-J., Yuen K.-Y.
J. Virol. 81:1574-1585(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HKU9-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF065513 Genomic RNA. Translation: ABN10915.1.
RefSeqYP_001039975.1. NC_009021.1.

3D structure databases

ProteinModelPortalA3EXH0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4836017.

Family and domain databases

InterProIPR001218. Corona_nucleocap.
[Graphical view]
PfamPF00937. Corona_nucleoca. 1 hit.
[Graphical view]
PIRSFPIRSF003888. Corona_nucleocap. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNCAP_BCHK9
AccessionPrimary (citable) accession number: A3EXH0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: October 16, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families