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A3EXH0

- NCAP_BCHK9

UniProt

A3EXH0 - NCAP_BCHK9

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Protein

Nucleoprotein

Gene

N

Organism
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NC
Short name:
Protein N
Gene namesi
Name:N
ORF Names:6
OrganismiBat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Taxonomic identifieri694006 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiRousettus leschenaultii (Leschenault's rousette) [TaxID: 9408]
ProteomesiUP000006576: Genome

Subcellular locationi

Virion By similarity. Host cytoplasmhost perinuclear region By similarity. Host endoplasmic reticulum-Golgi intermediate compartment By similarity. Host Golgi apparatus By similarity
Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding (By similarity).By similarity

GO - Cellular componenti

  1. host cell Golgi apparatus Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468NucleoproteinPRO_0000291327Add
BLAST

Interactioni

Subunit structurei

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliA3EXH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 193136RNA-bindingBy similarityAdd
BLAST
Regioni270 – 378109DimerizationBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 21729Ser-richAdd
BLAST
Compositional biasi314 – 3174Poly-Ala
Compositional biasi381 – 3877Poly-Lys

Sequence similaritiesi

Family and domain databases

InterProiIPR001218. Corona_nucleocap.
[Graphical view]
PfamiPF00937. Corona_nucleoca. 1 hit.
[Graphical view]
PIRSFiPIRSF003888. Corona_nucleocap. 1 hit.

Sequencei

Sequence statusi: Complete.

A3EXH0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSGRNRSRSG TPSPKVTFKQ ESDGSDSESE RRNGNRNGAR PKNNNSRGSA
60 70 80 90 100
PKPEKPKAAP PQNVSWFAPL VQTGKAELRF PRGEGVPVSQ GVDSTYEHGY
110 120 130 140 150
WLRTQRSFQK GGKQVLANPR WYFYYTGTGR FGDLRFGTKN PDIVWVGQEG
160 170 180 190 200
ANINRLGDMG TRNPSNDGAI PVQLAGGIPK GFYAEGRGSR GNSRSSSRNS
210 220 230 240 250
SRASSRGNSR ASSRGASPGR PAANPSTEPW MAYLVQKLER LESQVSGTKP
260 270 280 290 300
ATKNPVQVTK NEAAANAKKL RHKRTAHKGS GVTVNYGRRG PGDLEGNFGD
310 320 330 340 350
REMIKLGTDD PRFAAAAQMA PNVSSFLFMS HLSTRDEDDA LWLHYKGAIK
360 370 380 390 400
LPKDDPNYEQ WTKILAENLN AYKDFPPTEP KKDKKKKEET AQDTVIFEDA
410 420 430 440 450
STGTDQTVVK VWVKDQDAQT DDEWLGGDET VYEDEDDRPK TQRRHKKRGS
460
TASRVTIADP TNAGAERS
Length:468
Mass (Da):51,547
Last modified:March 20, 2007 - v1
Checksum:i188D262F3D9FAA0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF065513 Genomic RNA. Translation: ABN10915.1.
RefSeqiYP_001039975.1. NC_009021.1.

Genome annotation databases

GeneIDi4836017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF065513 Genomic RNA. Translation: ABN10915.1 .
RefSeqi YP_001039975.1. NC_009021.1.

3D structure databases

ProteinModelPortali A3EXH0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4836017.

Family and domain databases

InterProi IPR001218. Corona_nucleocap.
[Graphical view ]
Pfami PF00937. Corona_nucleoca. 1 hit.
[Graphical view ]
PIRSFi PIRSF003888. Corona_nucleocap. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features."
    Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L., Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H., Zheng B.-J., Yuen K.-Y.
    J. Virol. 81:1574-1585(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HKU9-1.

Entry informationi

Entry nameiNCAP_BCHK9
AccessioniPrimary (citable) accession number: A3EXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3