ID   A3E108_MONDO            Unreviewed;       186 AA.
AC   A3E108;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Insulin-like growth factor II {ECO:0000256|ARBA:ARBA00018566};
GN   Name=IGF2 {ECO:0000313|EMBL:ABG22162.1};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|EMBL:ABG22162.1};
RN   [1] {ECO:0000313|EMBL:ABG22162.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17268191; DOI=10.1159/000097431;
RA   Lawton B.R., Obergfell C., O'Neill R.J., O'Neill M.J.;
RT   "Physical mapping of the IGF2 locus in the South American opossum
RT   Monodelphis domestica.";
RL   Cytogenet. Genome Res. 116:130-131(2007).
CC   -!- FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin,
CC       and acts as a physiological amplifier of glucose-mediated insulin
CC       secretion. Exhibits osteogenic properties by increasing osteoblast
CC       mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
CC       {ECO:0000256|ARBA:ARBA00043916}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU000406}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR   EMBL; DQ519591; ABG22162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3E108; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   CDD; cd04368; IlGF; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR022334; IGF2.
DR   InterPro; IPR013576; IGF2_C.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR022350; Insulin-like_growth_factor.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR   PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR   Pfam; PF08365; IGF2_C; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02002; INSLNLIKEGF.
DR   PRINTS; PR02006; INSLNLIKEGF2.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
DR   PROSITE; PS00262; INSULIN; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..186
FT                   /note="Insulin-like growth factor II"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002652424"
FT   DOMAIN          30..88
FT                   /note="Insulin-like"
FT                   /evidence="ECO:0000259|SMART:SM00078"
FT   DISULFID        33..75
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        45..88
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        74..79
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ   SEQUENCE   186 AA;  20909 MW;  56BD00C6553CE511 CRC64;
     MGFPTKKMLL LSLTFLAFAS CCDAAYRPSE TLCGGELVDT LQFVCGDRGF YFSLPGRPLS
     RVSRRLNRGI VEECCFRSCD LALLETYCAT PAKSERDLSA SMMVLPDNFP RFPVGRFFKL
     DTWQKSAHRL RRGLPALLRA RRDRLRAQAL DAIREAKRHR PLISLPSGDP LRAELAAASE
     KAARQK
//