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A3DSK6

- VP2_ROTHL

UniProt

A3DSK6 - VP2_ROTHL

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/Philippines/L26/1987 G12-P1B[4]-I2-R2-C2-M1/M2-A2-N1-T2-E2-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain Human/Philippines/L26/1987 G12-P1B[4]-I2-R2-C2-M1/M2-A2-N1-T2-E2-H1) (RV-A)
Taxonomic identifieri10953 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001459: Genome

Subcellular locationi

Virion Curated
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Inner capsid protein VP2PRO_0000368060Add
BLAST

Interactioni

Subunit structurei

Dimer (Potential). Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9191Interaction with VP1 and VP3By similarityAdd
BLAST
Regioni393 – 41321HydrophobicBy similarityAdd
BLAST
Regioni421 – 44121HydrophobicBy similarityAdd
BLAST
Regioni535 – 55622Leucine-zipper 1Sequence AnalysisAdd
BLAST
Regioni664 – 68522Leucine-zipper 2Sequence AnalysisAdd
BLAST

Domaini

The N-terminus is involved in VP1 binding.By similarity

Sequence similaritiesi

Belongs to the rotavirus VP2 family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A3DSK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYRKRGARR EANLNNDDRM QEKNDEKQDS NKIQLSDKVL SKKEEVVTDS
60 70 80 90 100
HEEVKITDEA KKSTKEESKQ LLEVLKTKEE HQKEIQYEIL QKTIPTFEPK
110 120 130 140 150
ETILRKLEDI KPELAKKQTK LFRIFEPKQL PIYRANGERE LRNRWYWKLK
160 170 180 190 200
KDTLPDGDYD VREYFLNLYD QVLTEMPDYL LLKDMAVENK NSRDAGKVVD
210 220 230 240 250
SETASICDAI FQDEETEGAV RRFIAEMRQR VQADRNVVNY PSILHPIDYA
260 270 280 290 300
FNEYFLQHQL VEPLNNDIIF NYIPERIRND VNYILNMDRN LPSTARYIRP
310 320 330 340 350
NLLQDRLNLH DNFESLWDTI TTSNYILARS VVPDLKELVS TEAQIQKMSQ
360 370 380 390 400
DLQLEALTIQ SETQFLTGIN SQAANDCFKT LIAAMLSQRT MSLDFVTTNY
410 420 430 440 450
MSLISGMWLL TVIPNDMFIR ESLVACQLAI VNTIIYPAFG MQRMHYRNGD
460 470 480 490 500
PQTPFHIAEQ QIQNFQVANW LHFVNNNQFR QVVIDGVLNQ VLNDNIRNGH
510 520 530 540 550
VINQLMEALM QLSRQQFPTM PVDYKRSIQR GILLLSNRLG QLVDLTRLLA
560 570 580 590 600
YNYETLMACI TMNMQHVQTL TTEKLQLTSV TSLCMLIGNA TVIPSPQTLF
610 620 630 640 650
HYYNVNVNFH SNYNERINDA VAIITAANRL NLYQKKMKAI VEDFLKRLYI
660 670 680 690 700
FDVSRVPDDQ MYRLRDRLRL LPVEIRRLDI FNLILMNMDQ IERASDKIAQ
710 720 730 740 750
GVIIAYRDMH LERDEMYGYV NIARNLDGFQ QINLEELMRS GDYAQITNML
760 770 780 790 800
LNNQPVALVG ALPFITDSSV ISLIAKLDAT VFAQIVKLRK VDTLKPILYK
810 820 830 840 850
INSDSNDFYL VANYDWVPTS TTKVYKQVPQ QFDFRNSMHM LTSNLTFTVY
860 870
SDLLAFVSAD TVEPINAVAF DNMRIMNEL
Length:879
Mass (Da):102,408
Last modified:March 20, 2007 - v1
Checksum:iCA32597E757389A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ146694 Genomic RNA. Translation: ABA34197.1.
EF583034 Genomic RNA. Translation: ABU87843.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ146694 Genomic RNA. Translation: ABA34197.1 .
EF583034 Genomic RNA. Translation: ABU87843.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
    Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
    J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTHL
AccessioniPrimary (citable) accession number: A3DSK6
Secondary accession number(s): B1NKS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 20, 2007
Last modified: October 1, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3