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Protein

Dihydrolipoyl dehydrogenase

Gene

Smar_1115

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciSMAR399550:G1G8A-1201-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Smar_1115Imported
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)Imported
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000000254 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_1115

Structurei

3D structure databases

ProteinModelPortaliA3DNK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 306FAD/NAD-binding_domInterPro annotationAdd BLAST305
Domaini329 – 435Pyr_redox_dimInterPro annotationAdd BLAST107

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiarCOG01068 Archaea
COG1249 LUCA
HOGENOMiHOG000276708
KOiK00382
OMAiRKANHYG
OrthoDBiPOG093Z01YB

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit

Sequencei

Sequence statusi: Complete.

A3DNK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDVVVVGAG VGGYPAAIYL ARHGLKVAVI EEHLLGGECT NYGCVPSKAL
60 70 80 90 100
YNIAEAFRTI EKVGGNANID WNNLSRWVSS VVKETRNGIE YLLESYGVDI
110 120 130 140 150
INSKAVLKKD TAIKIGNDII SPKNIILALG TDPKPLPNVN FDGKYLLSNR
160 170 180 190 200
EVFYMEEKPE KILIIGGGVI GVEAAYTFSQ LGIDVTIVEA MPNILPFLDK
210 220 230 240 250
DISLTMKRFL REKNVKIYEN TFVEKITIEN NKVKAKLSNN NLIETDKILV
260 270 280 290 300
AIGRKPKTTN IGLETVRVET TQKGFIKVNE KYQTTNPRIY AVGDVIGEPL
310 320 330 340 350
LAHKAILESI AAARNILGEE SFSLSYHLVP QTIFSGLEIA WIGYTERELR
360 370 380 390 400
EKGIKYRRIR MPVSHLSAVR IKDSKYSYVK ILMDENNVPY GIFVVSPLAS
410 420 430 440 450
EVISSFIPFI MNKIRLEKAW RIPYPHLTVS ETVREISEYI LGEPIHLYLK

K
Length:451
Mass (Da):50,595
Last modified:March 20, 2007 - v1
Checksum:i6F8C95B7B6FA89AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA Translation: ABN70211.1
RefSeqiWP_011839402.1, NC_009033.1

Genome annotation databases

EnsemblBacteriaiABN70211; ABN70211; Smar_1115
GeneIDi4907983
KEGGismr:Smar_1115

Similar proteinsi

Entry informationi

Entry nameiA3DNK1_STAMF
AccessioniPrimary (citable) accession number: A3DNK1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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