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Protein

Dihydrolipoyl dehydrogenase

Gene

Smar_1115

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciSMAR399550:GHK2-1154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Smar_1115Imported
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)Imported
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000000254 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_1115.

Structurei

3D structure databases

ProteinModelPortaliA3DNK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 306305FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini329 – 435107Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiarCOG01068. Archaea.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTAMEFRA.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

A3DNK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDVVVVGAG VGGYPAAIYL ARHGLKVAVI EEHLLGGECT NYGCVPSKAL
60 70 80 90 100
YNIAEAFRTI EKVGGNANID WNNLSRWVSS VVKETRNGIE YLLESYGVDI
110 120 130 140 150
INSKAVLKKD TAIKIGNDII SPKNIILALG TDPKPLPNVN FDGKYLLSNR
160 170 180 190 200
EVFYMEEKPE KILIIGGGVI GVEAAYTFSQ LGIDVTIVEA MPNILPFLDK
210 220 230 240 250
DISLTMKRFL REKNVKIYEN TFVEKITIEN NKVKAKLSNN NLIETDKILV
260 270 280 290 300
AIGRKPKTTN IGLETVRVET TQKGFIKVNE KYQTTNPRIY AVGDVIGEPL
310 320 330 340 350
LAHKAILESI AAARNILGEE SFSLSYHLVP QTIFSGLEIA WIGYTERELR
360 370 380 390 400
EKGIKYRRIR MPVSHLSAVR IKDSKYSYVK ILMDENNVPY GIFVVSPLAS
410 420 430 440 450
EVISSFIPFI MNKIRLEKAW RIPYPHLTVS ETVREISEYI LGEPIHLYLK

K
Length:451
Mass (Da):50,595
Last modified:March 20, 2007 - v1
Checksum:i6F8C95B7B6FA89AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA. Translation: ABN70211.1.
RefSeqiWP_011839402.1. NC_009033.1.

Genome annotation databases

EnsemblBacteriaiABN70211; ABN70211; Smar_1115.
GeneIDi4907983.
KEGGismr:Smar_1115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA. Translation: ABN70211.1.
RefSeqiWP_011839402.1. NC_009033.1.

3D structure databases

ProteinModelPortaliA3DNK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399550.Smar_1115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN70211; ABN70211; Smar_1115.
GeneIDi4907983.
KEGGismr:Smar_1115.

Phylogenomic databases

eggNOGiarCOG01068. Archaea.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTAMEFRA.

Enzyme and pathway databases

BioCyciSMAR399550:GHK2-1154-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
    Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
    BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / JCM 9404 / F1Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / JCM 9404 / F1Imported.

Entry informationi

Entry nameiA3DNK1_STAMF
AccessioniPrimary (citable) accession number: A3DNK1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: April 13, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.