Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A3DNK0

- GCSPB_STAMF

UniProt

A3DNK0 - GCSPB_STAMF

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSMAR399550:GHK2-1153-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Smar_1114
    OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
    Taxonomic identifieri399550 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
    ProteomesiUP000000254: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi399550.Smar_1114.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DNK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiLGETPWD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3DNK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRQSRWDEP LIFELGNKGR KGFIVPEPEE EVKRKVGGIR IPEKILRKKP    50
    PNLPEVSEVE VIRHYTRLTE MSYGVDNGPV PLGSCTMKYN PRIAWEISND 100
    YRINMLHPLQ DERTIQGLLE ILYELQKWLA NITGMDYCSL HPAAGAHGEF 150
    SGILIIRKYH ELKKQLDRKS EIIIPDSAHG TNPASASMGG FKVVEVPSGE 200
    DGNIDMEALK SVVGESTAGL MITNPSTLGL FEENVVEISK IIHGVDGLLY 250
    YDGANLNGIM GYTRPGDMGF DIAHINIHKT FGAPHGGGGP GAGPVCVKDK 300
    LIDEERNIWL RDLLPGYRVV YDEKTGLYKL VNNEKYSIGL LKAFFGNIVP 350
    LIWGYTYILM LGSKGLRTVT EQAVLNTNYF ISLVKDIRGY DIPYGKDRYR 400
    KHEVVLSAKP LYDDTGVSAE DVAKGLLDAG FYAPTIYFPL IVHEALMTEF 450
    TESETIEYIE KYAERLQEIS TIAYSDPEKA KEWPLNTSVR RVDNVRANHP 500
    KTLAPTWRIY MEKVCRKYSE C 521
    Length:521
    Mass (Da):58,713
    Last modified:March 20, 2007 - v1
    Checksum:i48C8F4685295AADE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN70210.1.
    RefSeqiYP_001041118.1. NC_009033.1.

    Genome annotation databases

    EnsemblBacteriaiABN70210; ABN70210; Smar_1114.
    GeneIDi4907548.
    KEGGismr:Smar_1114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN70210.1 .
    RefSeqi YP_001041118.1. NC_009033.1.

    3D structure databases

    ProteinModelPortali A3DNK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399550.Smar_1114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN70210 ; ABN70210 ; Smar_1114 .
    GeneIDi 4907548.
    KEGGi smr:Smar_1114.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi LGETPWD.

    Enzyme and pathway databases

    BioCyci SMAR399550:GHK2-1153-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
      Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
      BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.

    Entry informationi

    Entry nameiGCSPB_STAMF
    AccessioniPrimary (citable) accession number: A3DNK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3