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A3DNJ9

- GCSPA_STAMF

UniProt

A3DNJ9 - GCSPA_STAMF

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciSMAR399550:GHK2-1152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Smar_1113
    OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
    Taxonomic identifieri399550 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
    ProteomesiUP000000254: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045682Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi399550.Smar_1113.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DNJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiGLEVANC.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3DNJ9-1 [UniParc]FASTAAdd to Basket

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    MDSHPWIPNS TREIREKMLE KIGVKNIDEF FNDIPRNIRI SKEEWDNLEI    50
    GLKKPISEIT ARRIIEEKLS MNKVFVPLLF LGGGAYPHYV PSVIKYLISR 100
    GEFLTSYTPY QPEISQGILQ ALFEYQSLMA ELLDMDVVNS SMYDWASALA 150
    EALLMSLRVK KNKKKILLPS NMNPIHKRVV NTYLSPHNVR IEYVNYNHDT 200
    GLIDLEDLKN KIDNDTAAVY VQSPNFFGYI EENAKEIGEI VHDIDSLFIM 250
    GIDPISLGLI KPPGELGADI AVGEGQPLGL GLNYGGPYLG IFATRMDMKL 300
    VRQMPGRIIG LTRSVDGSRA FTMILQTREQ HIRRAKATSN ICTNEALSAI 350
    AAAIYLALLG KSGIRKLAEL IYYRSHYAQA RLREIGLNTD IFKSDFFKEF 400
    PINFDNIGVK YRYVHEKLLE NNIHGGLYIG NWFPELGETA LYAFTEIHTK 450
    NDIDLLVEKL ADIINELKR 469
    Length:469
    Mass (Da):53,318
    Last modified:March 20, 2007 - v1
    Checksum:iB4BB0F8145A0EA11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN70209.1.
    RefSeqiWP_011839400.1. NC_009033.1.
    YP_001041117.1. NC_009033.1.

    Genome annotation databases

    EnsemblBacteriaiABN70209; ABN70209; Smar_1113.
    GeneIDi4907540.
    KEGGismr:Smar_1113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN70209.1 .
    RefSeqi WP_011839400.1. NC_009033.1.
    YP_001041117.1. NC_009033.1.

    3D structure databases

    ProteinModelPortali A3DNJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399550.Smar_1113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN70209 ; ABN70209 ; Smar_1113 .
    GeneIDi 4907540.
    KEGGi smr:Smar_1113.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi GLEVANC.

    Enzyme and pathway databases

    BioCyci SMAR399550:GHK2-1152-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
      Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
      BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.

    Entry informationi

    Entry nameiGCSPA_STAMF
    AccessioniPrimary (citable) accession number: A3DNJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3