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A3DNJ9

- GCSPA_STAMF

UniProt

A3DNJ9 - GCSPA_STAMF

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Smar_1113
Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSMAR399550:GHK2-1152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Smar_1113
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
ProteomesiUP000000254: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045682Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi399550.Smar_1113.

Structurei

3D structure databases

ProteinModelPortaliA3DNJ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiGLEVANC.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A3DNJ9-1 [UniParc]FASTAAdd to Basket

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MDSHPWIPNS TREIREKMLE KIGVKNIDEF FNDIPRNIRI SKEEWDNLEI    50
GLKKPISEIT ARRIIEEKLS MNKVFVPLLF LGGGAYPHYV PSVIKYLISR 100
GEFLTSYTPY QPEISQGILQ ALFEYQSLMA ELLDMDVVNS SMYDWASALA 150
EALLMSLRVK KNKKKILLPS NMNPIHKRVV NTYLSPHNVR IEYVNYNHDT 200
GLIDLEDLKN KIDNDTAAVY VQSPNFFGYI EENAKEIGEI VHDIDSLFIM 250
GIDPISLGLI KPPGELGADI AVGEGQPLGL GLNYGGPYLG IFATRMDMKL 300
VRQMPGRIIG LTRSVDGSRA FTMILQTREQ HIRRAKATSN ICTNEALSAI 350
AAAIYLALLG KSGIRKLAEL IYYRSHYAQA RLREIGLNTD IFKSDFFKEF 400
PINFDNIGVK YRYVHEKLLE NNIHGGLYIG NWFPELGETA LYAFTEIHTK 450
NDIDLLVEKL ADIINELKR 469
Length:469
Mass (Da):53,318
Last modified:March 20, 2007 - v1
Checksum:iB4BB0F8145A0EA11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000575 Genomic DNA. Translation: ABN70209.1.
RefSeqiWP_011839400.1. NC_009033.1.
YP_001041117.1. NC_009033.1.

Genome annotation databases

EnsemblBacteriaiABN70209; ABN70209; Smar_1113.
GeneIDi4907540.
KEGGismr:Smar_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000575 Genomic DNA. Translation: ABN70209.1 .
RefSeqi WP_011839400.1. NC_009033.1.
YP_001041117.1. NC_009033.1.

3D structure databases

ProteinModelPortali A3DNJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399550.Smar_1113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN70209 ; ABN70209 ; Smar_1113 .
GeneIDi 4907540.
KEGGi smr:Smar_1113.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi GLEVANC.

Enzyme and pathway databases

BioCyci SMAR399550:GHK2-1152-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
    Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
    BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / F1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / F1.

Entry informationi

Entry nameiGCSPA_STAMF
AccessioniPrimary (citable) accession number: A3DNJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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