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A3DNJ9 (GCSPA_STAMF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Smar_1113
OrganismStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1) [Complete proteome] [HAMAP]
Taxonomic identifier399550 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045682

Sequences

Sequence LengthMass (Da)Tools
A3DNJ9 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: B4BB0F8145A0EA11

FASTA46953,318
        10         20         30         40         50         60 
MDSHPWIPNS TREIREKMLE KIGVKNIDEF FNDIPRNIRI SKEEWDNLEI GLKKPISEIT 

        70         80         90        100        110        120 
ARRIIEEKLS MNKVFVPLLF LGGGAYPHYV PSVIKYLISR GEFLTSYTPY QPEISQGILQ 

       130        140        150        160        170        180 
ALFEYQSLMA ELLDMDVVNS SMYDWASALA EALLMSLRVK KNKKKILLPS NMNPIHKRVV 

       190        200        210        220        230        240 
NTYLSPHNVR IEYVNYNHDT GLIDLEDLKN KIDNDTAAVY VQSPNFFGYI EENAKEIGEI 

       250        260        270        280        290        300 
VHDIDSLFIM GIDPISLGLI KPPGELGADI AVGEGQPLGL GLNYGGPYLG IFATRMDMKL 

       310        320        330        340        350        360 
VRQMPGRIIG LTRSVDGSRA FTMILQTREQ HIRRAKATSN ICTNEALSAI AAAIYLALLG 

       370        380        390        400        410        420 
KSGIRKLAEL IYYRSHYAQA RLREIGLNTD IFKSDFFKEF PINFDNIGVK YRYVHEKLLE 

       430        440        450        460 
NNIHGGLYIG NWFPELGETA LYAFTEIHTK NDIDLLVEKL ADIINELKR 

« Hide

References

[1]"The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43588 / DSM 3639 / F1.
[2]"Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986 type strain F1."
Anderson I.J., Sun H., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Lucas S., Barry K., Land M., Richardson P., Huber H., Kyrpides N.C.
Stand. Genomic Sci. 1:183-188(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43588 / DSM 3639 / F1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000575 Genomic DNA. Translation: ABN70209.1.
RefSeqYP_001041117.1. NC_009033.1.

3D structure databases

ProteinModelPortalA3DNJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399550.Smar_1113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN70209; ABN70209; Smar_1113.
GeneID4907540.
KEGGsmr:Smar_1113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAGLEVANC.

Enzyme and pathway databases

BioCycSMAR399550:GHK2-1152-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_STAMF
AccessionPrimary (citable) accession number: A3DNJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families