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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

Smar_0993

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24MagnesiumUniRule annotation1
Metal bindingi54MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSMAR399550:G1G8A-1074-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Smar_0993
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000000254 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003506871 – 245Geranylgeranylglyceryl phosphate synthaseAdd BLAST245

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_0993

Structurei

3D structure databases

ProteinModelPortaliA3DN81
SMRiA3DN81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 178Glycerol-1-phosphate bindingUniRule annotation7
Regioni203 – 204Glycerol-1-phosphate bindingUniRule annotation2
Regioni225 – 226Glycerol-1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085 Archaea
COG1646 LUCA
HOGENOMiHOG000034117
KOiK17104
OMAiADAIFFM
OrthoDBiPOG093Z0C46

Family and domain databases

CDDicd02812 PcrB_like, 1 hit
Gene3Di3.20.20.390, 1 hit
HAMAPiMF_00112 GGGP_HepGP_synthase, 1 hit
InterProiView protein in InterPro
IPR038597 GGGP/HepGP_synthase_sf
IPR008205 GGGP_HepGP_synthase
IPR010946 GGGP_synth
PfamiView protein in Pfam
PF01884 PcrB, 1 hit
TIGRFAMsiTIGR01769 GGGP, 1 hit
TIGR01768 GGGP-family, 1 hit

Sequencei

Sequence statusi: Complete.

A3DN81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVNKYIVE KINNGEKLHF TLIDPDRVND LGKLEETAIK MAEFGTDAFL
60 70 80 90 100
IGGSLGVTPE EAGETAKILK KTGLPVIIFP GNINCLTPYA DAVLFMILMN
110 120 130 140 150
SMEQYYLMHA QIAAAPIIKK YKLETLPTGY IVIYGETAVA HVGRTYPIPV
160 170 180 190 200
SKPEILLSYT WAAEMIGIKY IYLEAGSGSP KPVPPSFPAI VKKYTNLITI
210 220 230 240
VGGGIRSPFI AKELASSGAD IIVTGTIVEE DPDKASKIIS AIKKN
Length:245
Mass (Da):26,533
Last modified:March 20, 2007 - v1
Checksum:i9B0AC265C0CDA4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA Translation: ABN70091.1
RefSeqiWP_011839282.1, NC_009033.1

Genome annotation databases

EnsemblBacteriaiABN70091; ABN70091; Smar_0993
GeneIDi4908007
KEGGismr:Smar_0993

Similar proteinsi

Entry informationi

Entry nameiGGGPS_STAMF
AccessioniPrimary (citable) accession number: A3DN81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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