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A3DMR5

- SYE_STAMF

UniProt

A3DMR5 - SYE_STAMF

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMAR399550:GHK2-844-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Smar_0824
    OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
    Taxonomic identifieri399550 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
    ProteomesiUP000000254: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Glutamate--tRNA ligasePRO_0000367805Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399550.Smar_0824.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DMR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi93 – 10311"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3DMR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNAYKHSGK AELKPVISKI IAEIPEIRRH VREVIDIVRE TINEVNQLPI    50
    EKQKEIIEKN WPELLEEKPR TEEKSLPPLP NAAKGRVVTR FAPNPDYTIH 100
    LGNARPALLS YWYAEMYEGK MILRFEDTDP RTKAPFPEAY DRIRNDLKWL 150
    GIKWNEEYIQ SLRLPILYNA LRELIKHGGA YVDKCSPKEF KKLRDSGKPC 200
    PHRELPPEKH LEELDRIFEG YYSEGEAVVR VKTDLSHPDP SVRDWVAARI 250
    IDTSKTPHPI VGDKYILWPT YNLAAAIDDH LMGVTHILRA KEHVSNTIKQ 300
    KFLYDHMGWK YPETIHFGRL SLEGVILSKS RMRKMIVEYN MEPYDDPRFG 350
    TLSGLRRRGI VRETLWRIIK DVGINVIDAR ISYVNLAAIN RSIIDPQAKR 400
    YMAIEEALPL KLIGFNNSIE AHVLRHPSTR ETYNYIIKPG DIVYISQKDF 450
    NIIQNKMFRL MGIGNFALTR PVFSKNYIGF EARLISLSAK EAKQYRAPII 500
    QWVKLEQSIR VKLIIPKETN LETRILLAEK ALTNEELGNI VQFYRIGFAR 550
    IDSKEPEEIK CIFAHE 566
    Length:566
    Mass (Da):65,806
    Last modified:March 20, 2007 - v1
    Checksum:i2684D577A98F429D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN69925.1.
    RefSeqiWP_011839116.1. NC_009033.1.
    YP_001040833.1. NC_009033.1.

    Genome annotation databases

    EnsemblBacteriaiABN69925; ABN69925; Smar_0824.
    GeneIDi4907409.
    KEGGismr:Smar_0824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000575 Genomic DNA. Translation: ABN69925.1 .
    RefSeqi WP_011839116.1. NC_009033.1.
    YP_001040833.1. NC_009033.1.

    3D structure databases

    ProteinModelPortali A3DMR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399550.Smar_0824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN69925 ; ABN69925 ; Smar_0824 .
    GeneIDi 4907409.
    KEGGi smr:Smar_0824.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Enzyme and pathway databases

    BioCyci SMAR399550:GHK2-844-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
      Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
      BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43588 / DSM 3639 / F1.

    Entry informationi

    Entry nameiSYE_STAMF
    AccessioniPrimary (citable) accession number: A3DMR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3