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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Smar_0824
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678051 – 566Glutamate--tRNA ligaseAdd BLAST566

Proteomic databases

PRIDEiA3DMR5

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_0824

Structurei

3D structure databases

ProteinModelPortaliA3DMR5
SMRiA3DMR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 103"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

A3DMR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNAYKHSGK AELKPVISKI IAEIPEIRRH VREVIDIVRE TINEVNQLPI
60 70 80 90 100
EKQKEIIEKN WPELLEEKPR TEEKSLPPLP NAAKGRVVTR FAPNPDYTIH
110 120 130 140 150
LGNARPALLS YWYAEMYEGK MILRFEDTDP RTKAPFPEAY DRIRNDLKWL
160 170 180 190 200
GIKWNEEYIQ SLRLPILYNA LRELIKHGGA YVDKCSPKEF KKLRDSGKPC
210 220 230 240 250
PHRELPPEKH LEELDRIFEG YYSEGEAVVR VKTDLSHPDP SVRDWVAARI
260 270 280 290 300
IDTSKTPHPI VGDKYILWPT YNLAAAIDDH LMGVTHILRA KEHVSNTIKQ
310 320 330 340 350
KFLYDHMGWK YPETIHFGRL SLEGVILSKS RMRKMIVEYN MEPYDDPRFG
360 370 380 390 400
TLSGLRRRGI VRETLWRIIK DVGINVIDAR ISYVNLAAIN RSIIDPQAKR
410 420 430 440 450
YMAIEEALPL KLIGFNNSIE AHVLRHPSTR ETYNYIIKPG DIVYISQKDF
460 470 480 490 500
NIIQNKMFRL MGIGNFALTR PVFSKNYIGF EARLISLSAK EAKQYRAPII
510 520 530 540 550
QWVKLEQSIR VKLIIPKETN LETRILLAEK ALTNEELGNI VQFYRIGFAR
560
IDSKEPEEIK CIFAHE
Length:566
Mass (Da):65,806
Last modified:March 20, 2007 - v1
Checksum:i2684D577A98F429D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA Translation: ABN69925.1

Genome annotation databases

EnsemblBacteriaiABN69925; ABN69925; Smar_0824
KEGGismr:Smar_0824

Similar proteinsi

Entry informationi

Entry nameiSYE_STAMF
AccessioniPrimary (citable) accession number: A3DMR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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