A3DMF7 (PTH_STAMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	Smar_0714

Organism

Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1) [Complete proteome] [HAMAP]

Taxonomic identifier

399550 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Staphylothermus

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00628
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00628
Subcellular location	Cytoplasm By similarity HAMAP MF_00628.
Sequence similarities	Belongs to the PTH2 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	Peptidyl-tRNA hydrolase HAMAP MF_00628		PRO_1000051681

Sequences

	Sequence		Length	Mass (Da)
	A3DMF7 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 5EBCEF41BE29A872	FASTA	121	13,463
	10 20 30 40 50 60 MLRNTEYKQV IIVRTDIKMS KGKLAVQVAH AAVSAAFEAY KKKREWFLEW WATGQKKIVV 70 80 90 100 110 120 KGGSERDLLK YAEMAKKKDL PVAIIRDAGL TELPPNTLTA VGIGPGPSRK IDEITGDLKL L

References

[1]

"The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota." Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N. BMC Genomics 10:145-145(2009) [PubMed: 19341479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43588 / DSM 3639 / F1.

[2]

"Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986 type strain F1." Anderson I.J., Sun H., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Lucas S., Barry K., Land M., Richardson P., Huber H., Kyrpides N.C. Stand. Genomic Sci. 1:183-188(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43588 / DSM 3639 / F1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000575 Genomic DNA. Translation: ABN69817.1.
RefSeq	YP_001040725.1. NC_009033.1.
3D structure databases
ProteinModelPortal	A3DMF7.
SMR	A3DMF7. Positions 6-121.
ModBase	Search...
Protein-protein interaction databases
STRING	A3DMF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4907998.
GenomeReviews	Gene locus Smar_0714 in contig CP000575_GR.
KEGG	smr:Smar_0714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG11345.
HOGENOM	HBG526257.
OMA	KSLVMEY.
PhylomeDB	A3DMF7.
ProtClustDB	PRK04322.
Enzyme and pathway databases
BioCyc	SMAR399550:SMAR_0714-MONOMER.
Family and domain databases
HAMAP	MF_00628. Pept_tRNA_hydro_arch. [Tree]
InterPro	IPR023476. Pep_tRNA_hydro_II_dom. IPR002833. Pep_tRNA_hydro_PTH2. [Graphical view]
Gene3D	G3DSA:3.40.1490.10. G3DSA:3.40.1490.10. 1 hit.
KO	K04794.
PANTHER	PTHR12649:SF6. PTHR12649:SF6. 1 hit.
Pfam	PF01981. PTH2. 1 hit. [Graphical view]
SUPFAM	SSF102462. SSF102462. 1 hit.
TIGRFAMs	TIGR00283. Arch_pth2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTH_STAMF

Accession

Primary (citable) accession number: A3DMF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	November 16, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program