A3DM44 (A3DM44_STAMF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
Ordered Locus Names:	Smar_0597

Organism

Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1) [Complete proteome] [HAMAP]

Taxonomic identifier

399550 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Staphylothermus

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN HAMAP MF_00224 Flavoprotein HAMAP MF_00224
Molecular function	Oxidoreductase HAMAP MF_00224 EMBL ABN69704.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	127	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	A3DM44 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: D1AACE63ECC8FC5C	FASTA	301	32,106
	10 20 30 40 50 60 MDLTTKVTGI VFKHPIMNAS GILASSINGV GILAKTGVAG IVTKTLTLKP REGYLPPITI 70 80 90 100 110 120 PLDYGLLNAV GLANPGIDAV NVLVEEIHKY GLPAIVSIGG RDPREFQILA EKALDARPEA 130 140 150 160 170 180 LELNLSCPHT PGFGVDTVAT DEVLKHVALN VSSVSNIPVW GKLGFSRRII RESEILLNNG 190 200 210 220 230 240 VDAVVLINTL PGMFIDVYVG KPVLTHGFGG LSGPAIHPVA VYSVYKVYEE LGAEIIGVGG 250 260 270 280 290 300 VIDWKTSVEL LLAGAKAIQI GTGFYMVGYN IVNNILDGIK KYMEEKGFTR ISDIIGYAHR K

References

[1]

"Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986 type strain F1." Anderson I.J., Sun H., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Lucas S., Barry K., Land M., Richardson P., Huber H., Kyrpides N.C. Stand. Genomic Sci. 1:183-188(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota." Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N. BMC Genomics 10:145-145(2009) [PubMed: 19341479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000575 Genomic DNA. Translation: ABN69704.1.
RefSeq	YP_001040612.1. NC_009033.1.
3D structure databases
ProteinModelPortal	A3DM44.
ModBase	Search...
Protein-protein interaction databases
STRING	A3DM44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4906749.
GenomeReviews	Gene locus Smar_0597 in contig CP000575_GR.
KEGG	smr:Smar_0597.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04551.
HOGENOM	HBG472415.
OMA	VALRMVW.
PhylomeDB	A3DM44.
ProtClustDB	CLSK2785960.
Enzyme and pathway databases
BioCyc	SMAR399550:SMAR_0597-MONOMER.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3DM44_STAMF

Accession

Primary (citable) accession number: A3DM44

Entry history

Integrated into UniProtKB/TrEMBL:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)