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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei652ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAR399550:G1G8A-121-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Smar_0118
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000000254 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348481 – 969Leucine--tRNA ligaseAdd BLAST969

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_0118

Structurei

3D structure databases

ProteinModelPortaliA3DKS1
SMRiA3DKS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 55"HIGH" regionAdd BLAST11
Motifi649 – 653"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A3DKS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRDFLEWL RSVEAKWQSK WMEKKIFEPR IEPDKPKYFI TVPYPYTNAP
60 70 80 90 100
LHIGHGRTYT IGDIIARYKR LRGYNVLFPM AFHITGTPII AISERISRGE
110 120 130 140 150
EEIINRYKSY IAKYVKDPVE IEKIIESFKD PLNLAVFFAE RVHMDFDALG
160 170 180 190 200
YSIDWRRRFH TGEPIYNAFV TWQFLKLREK GLIKRGDHVV TYCLLHKQPE
210 220 230 240 250
GEDDIQDADV NPVEILEFTA IKFKLLGEEN TYLVAATLRP ETLFGATNLW
260 270 280 290 300
VKPDADYVVV EWRGENIIVS KEALVKLQHQ HPLDEFKVVG EMKGRELVGK
310 320 330 340 350
KVVSPLGNEL IVLPADFVDP DNATGIVYSE PSDAPYDYVA LMELKKNSEK
360 370 380 390 400
LAMYGVDPEV VKKIEPIKII DVPGIKGHHA GIVVEEMGIS SQFDPRLVEA
410 420 430 440 450
TKIVYREQYY KGVMIVDDPE FKGLSVSEAK EKIKKKLLRE NKGFVFYELN
460 470 480 490 500
RKAYCRAGGK IIAAKIIGQW FIDYSVPWWK EEAKKYVSEK MRIIPVKYKK
510 520 530 540 550
AMLDAIDWLE RRPCARKRGL GTRLPFDPEW VIESLSDSTI YMAFYTIAHL
560 570 580 590 600
IRKHNIKPEQ LKPQVFDYVF LGKGDPEEIS EDTGIPLKAL EEMRQEFNYW
610 620 630 640 650
YPVDQRHTGI AHISNHLSFF IYHHIAIFPR KHWPKMITLN EMVIREGTKM
660 670 680 690 700
SKSKGNVILL RDIAEKYSAD LFRLYIAGAA NLDTVLDWRE KEVERVIDSL
710 720 730 740 750
KKFTAIAEKA IRTKCGTYSH DKYIDKWFLS KFNRLLAEAT NALDNMEIRD
760 770 780 790 800
YVQKMFYDVM VSIDHYRERT SNEETICMIK RILSKWLKSL NPVIPHLTEE
810 820 830 840 850
IWSWMGKEEF LSLEKWPEID YKAINEEVEY LEEAIEALIE DIKNVLNILS
860 870 880 890 900
PKPKHAYIVV ASPWKREVIE MIEKGMDRRE IIRTIRDKYG LKGREKEIVY
910 920 930 940 950
VIQECSRTPC KRALKIDPIH EYEAYNEARQ YIAKKTGLHI EVYWEEEAKA
960
KNIPKAEKTL PLKPSFYLY
Length:969
Mass (Da):113,418
Last modified:March 20, 2007 - v1
Checksum:iF8EFAE27BDF6D1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA Translation: ABN69231.1
RefSeqiWP_011838422.1, NC_009033.1

Genome annotation databases

EnsemblBacteriaiABN69231; ABN69231; Smar_0118
GeneIDi4906962
KEGGismr:Smar_0118

Similar proteinsi

Entry informationi

Entry nameiSYL_STAMF
AccessioniPrimary (citable) accession number: A3DKS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health