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A3DKS1

- SYL_STAMF

UniProt

A3DKS1 - SYL_STAMF

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei652 – 6521ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAR399550:GHK2-118-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Smar_0118
OrganismiStaphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1)
Taxonomic identifieri399550 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
ProteomesiUP000000254: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Leucine--tRNA ligasePRO_0000334848Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399550.Smar_0118.

Structurei

3D structure databases

ProteinModelPortaliA3DKS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionAdd
BLAST
Motifi649 – 6535"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DKS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKRDFLEWL RSVEAKWQSK WMEKKIFEPR IEPDKPKYFI TVPYPYTNAP
60 70 80 90 100
LHIGHGRTYT IGDIIARYKR LRGYNVLFPM AFHITGTPII AISERISRGE
110 120 130 140 150
EEIINRYKSY IAKYVKDPVE IEKIIESFKD PLNLAVFFAE RVHMDFDALG
160 170 180 190 200
YSIDWRRRFH TGEPIYNAFV TWQFLKLREK GLIKRGDHVV TYCLLHKQPE
210 220 230 240 250
GEDDIQDADV NPVEILEFTA IKFKLLGEEN TYLVAATLRP ETLFGATNLW
260 270 280 290 300
VKPDADYVVV EWRGENIIVS KEALVKLQHQ HPLDEFKVVG EMKGRELVGK
310 320 330 340 350
KVVSPLGNEL IVLPADFVDP DNATGIVYSE PSDAPYDYVA LMELKKNSEK
360 370 380 390 400
LAMYGVDPEV VKKIEPIKII DVPGIKGHHA GIVVEEMGIS SQFDPRLVEA
410 420 430 440 450
TKIVYREQYY KGVMIVDDPE FKGLSVSEAK EKIKKKLLRE NKGFVFYELN
460 470 480 490 500
RKAYCRAGGK IIAAKIIGQW FIDYSVPWWK EEAKKYVSEK MRIIPVKYKK
510 520 530 540 550
AMLDAIDWLE RRPCARKRGL GTRLPFDPEW VIESLSDSTI YMAFYTIAHL
560 570 580 590 600
IRKHNIKPEQ LKPQVFDYVF LGKGDPEEIS EDTGIPLKAL EEMRQEFNYW
610 620 630 640 650
YPVDQRHTGI AHISNHLSFF IYHHIAIFPR KHWPKMITLN EMVIREGTKM
660 670 680 690 700
SKSKGNVILL RDIAEKYSAD LFRLYIAGAA NLDTVLDWRE KEVERVIDSL
710 720 730 740 750
KKFTAIAEKA IRTKCGTYSH DKYIDKWFLS KFNRLLAEAT NALDNMEIRD
760 770 780 790 800
YVQKMFYDVM VSIDHYRERT SNEETICMIK RILSKWLKSL NPVIPHLTEE
810 820 830 840 850
IWSWMGKEEF LSLEKWPEID YKAINEEVEY LEEAIEALIE DIKNVLNILS
860 870 880 890 900
PKPKHAYIVV ASPWKREVIE MIEKGMDRRE IIRTIRDKYG LKGREKEIVY
910 920 930 940 950
VIQECSRTPC KRALKIDPIH EYEAYNEARQ YIAKKTGLHI EVYWEEEAKA
960
KNIPKAEKTL PLKPSFYLY
Length:969
Mass (Da):113,418
Last modified:March 20, 2007 - v1
Checksum:iF8EFAE27BDF6D1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA. Translation: ABN69231.1.
RefSeqiWP_011838422.1. NC_009033.1.
YP_001040139.1. NC_009033.1.

Genome annotation databases

EnsemblBacteriaiABN69231; ABN69231; Smar_0118.
GeneIDi4906962.
KEGGismr:Smar_0118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000575 Genomic DNA. Translation: ABN69231.1 .
RefSeqi WP_011838422.1. NC_009033.1.
YP_001040139.1. NC_009033.1.

3D structure databases

ProteinModelPortali A3DKS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399550.Smar_0118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN69231 ; ABN69231 ; Smar_0118 .
GeneIDi 4906962.
KEGGi smr:Smar_0118.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci SMAR399550:GHK2-118-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota."
    Anderson I.J., Dharmarajan L., Rodriguez J., Hooper S., Porat I., Ulrich L.E., Elkins J.G., Mavromatis K., Sun H., Land M., Lapidus A., Lucas S., Barry K., Huber H., Zhulin I.B., Whitman W.B., Mukhopadhyay B., Woese C., Bristow J., Kyrpides N.
    BMC Genomics 10:145-145(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / F1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43588 / DSM 3639 / F1.

Entry informationi

Entry nameiSYL_STAMF
AccessioniPrimary (citable) accession number: A3DKS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3