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Protein
Submitted name:

Metallophosphoesterase

Gene

Cthe_2768

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ADPCombined sources1
Binding sitei116ATPCombined sources1
Binding sitei116CTPCombined sources1
Binding sitei116GTPCombined sources1
Binding sitei120ADPCombined sources1
Binding sitei162GTPCombined sources1
Metal bindingi187ManganeseCombined sources1
Metal bindingi189Manganese; via tele nitrogenCombined sources1
Metal bindingi233ManganeseCombined sources1
Binding sitei531ATPCombined sources1
Binding sitei536ADPCombined sources1
Binding sitei536AMPCombined sources1
Binding sitei536ATPCombined sources1
Binding sitei565ADPCombined sources1
Binding sitei565ATPCombined sources1
Binding sitei607ADPCombined sources1
Binding sitei607AMPCombined sources1
Binding sitei607ATPCombined sources1
Binding sitei687AMPCombined sources1
Binding sitei704ADPCombined sources1
Binding sitei704AMPCombined sources1
Binding sitei704ATPCombined sources1
Metal bindingi731Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi734Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi737Magnesium; via carbonyl oxygenCombined sources1
Binding sitei769AMPCombined sources1
Binding sitei774ADPCombined sources1
Binding sitei774AMPCombined sources1
Binding sitei774ATPCombined sources1
Binding sitei792ADPCombined sources1
Binding sitei792AMPCombined sources1
Binding sitei792ATPCombined sources1
Binding sitei824ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 23ATPCombined sources7
Nucleotide bindingi17 – 23CTPCombined sources7
Nucleotide bindingi17 – 23GTPCombined sources7
Nucleotide bindingi18 – 23ADPCombined sources6
Nucleotide bindingi120 – 123ATPCombined sources4
Nucleotide bindingi120 – 123CTPCombined sources4
Nucleotide bindingi120 – 123GTPCombined sources4
Nucleotide bindingi495 – 496ADPCombined sources2
Nucleotide bindingi529 – 532AMPCombined sources4

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingCombined sources, GTP-bindingCombined sources, MagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.78. 1530.

Names & Taxonomyi

Protein namesi
Submitted name:
MetallophosphoesteraseImported
Gene namesi
Ordered Locus Names:Cthe_2768Imported
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)Imported
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-60067N.
STRINGi203119.Cthe_2768.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TY5X-ray2.40A/B479-870[»]
3TY8X-ray2.60A/B479-870[»]
3TY9X-ray3.12A/B/C/D479-870[»]
4DRFX-ray2.60A/C445-870[»]
4E6NX-ray2.39A/C445-870[»]
4GP6X-ray2.10A/B1-170[»]
4GP7X-ray2.00A/B1-170[»]
4J6OX-ray1.60A/B171-424[»]
4JSTX-ray2.03A/B1-170[»]
4JSYX-ray2.14A/B1-170[»]
4JT2X-ray2.49A/B1-170[»]
4JT4X-ray2.01A/B1-170[»]
4MDEX-ray1.80A/B1-170[»]
4MDFX-ray1.73A/B1-170[»]
4QM6X-ray1.50A/B1-170[»]
4QM7X-ray1.80A/B1-170[»]
ProteinModelPortaliA3DJ38.
SMRiA3DJ38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 380MetallophosInterPro annotationAdd BLAST200
Domaini474 – 807PNKP_ligaseInterPro annotationAdd BLAST334
Domaini811 – 870PNKP-ligase_CInterPro annotationAdd BLAST60

Phylogenomic databases

eggNOGiENOG4107S1Q. Bacteria.
COG0639. LUCA.
COG4639. LUCA.
HOGENOMiHOG000245786.
KOiK01090.
OMAiVCEEKHM.
OrthoDBiPOG091H03NB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR027417. P-loop_NTPase.
IPR024028. PNKP_bac.
IPR032390. PNKP_C.
IPR032380. PNKP_ligase_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16536. PNKP-ligase_C. 1 hit.
PF16542. PNKP_ligase. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR04075. bacter_Pnkp. 1 hit.

Sequencei

Sequence statusi: Complete.

A3DJ38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTIPELSL VVLIGSSGSG KSTFAKKHFK PTEVISSDFC RGLVSDDEND
60 70 80 90 100
QTVTGAAFDV LHYIVSKRLQ LGKLTVVDAT NVQESARKPL IEIAKDYHCF
110 120 130 140 150
PVAVVFNLPE KVCQERNKNR TDRQVEEYVI RKHTQQLKKS IKGLQREGFR
160 170 180 190 200
YVYILNSPEE VEEVVFERQP LWNNKKDEHG PFDIIGDIHG CYDELKMLLE
210 220 230 240 250
KLGYLIEEVE GGVGSGKYRV THPEGRKVLF LGDLVDRGPK ITEVLKLVMG
260 270 280 290 300
MVKSGIALCV PGNHDVKLLR KLNGRDVQIT HGLDRTLEQL AKEPQEFIEE
310 320 330 340 350
VKAFIDGLVS HYVLDDGKLV VAHAGMKEEF QGRGSGKVRE FALYGETTGE
360 370 380 390 400
TDEYGLPVRY DWASDYRGKA LVVYGHTPQA EVLKVNNTIN IDTGCVFGGK
410 420 430 440 450
LTAYRYPERE IVDVKALKTY YEPAKPFLPK EDMAERFEAR TDNDILDIND
460 470 480 490 500
VLGKKIITTR LMSSITIHEE NSIAALEVMS RFAADPHWLI YLPPTMSPCE
510 520 530 540 550
TSKKEGMLEH PIEAFEYFRT RGVGKVVCEQ KHMGSRAVVI VCKDSQVAEK
560 570 580 590 600
RFGVLDGTAG ICYTRTGRHF FDDMQLEAEL IDRVRKVLDK SGFWGDFNTD
610 620 630 640 650
WVCLDCELMP WSAKAQKLLE EQYSAVGISG RVVLDEAVKL LKQASLNKTV
660 670 680 690 700
SFDVSRQTSG KNADINELLQ RFTERSEMMQ KYVEAYRKYC WPVNSIDDLK
710 720 730 740 750
LAPFHILATE GKVHSDKNHI WHMDTIAKYC TQDDSLIMAT NHILVDVTDA
760 770 780 790 800
ESVDKGIKWW EDLTASGGEG MVVKPYDFIV KNGRELLQPA VKCRGREYLR
810 820 830 840 850
IIYGPEYTMD ENIERLRNRA VGKKRSLALR EFSLGMEALE RFVRNEPLYR
860 870
VHECVFGVLA LESEPVDPRL
Length:870
Mass (Da):98,776
Last modified:March 20, 2007 - v1
Checksum:i11CA5878DD2919E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53967.1.
RefSeqiWP_020457916.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN53967; ABN53967; Cthe_2768.
KEGGicth:Cthe_2768.
PATRICi19519588. VBICloThe47081_2947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53967.1.
RefSeqiWP_020457916.1. NC_009012.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TY5X-ray2.40A/B479-870[»]
3TY8X-ray2.60A/B479-870[»]
3TY9X-ray3.12A/B/C/D479-870[»]
4DRFX-ray2.60A/C445-870[»]
4E6NX-ray2.39A/C445-870[»]
4GP6X-ray2.10A/B1-170[»]
4GP7X-ray2.00A/B1-170[»]
4J6OX-ray1.60A/B171-424[»]
4JSTX-ray2.03A/B1-170[»]
4JSYX-ray2.14A/B1-170[»]
4JT2X-ray2.49A/B1-170[»]
4JT4X-ray2.01A/B1-170[»]
4MDEX-ray1.80A/B1-170[»]
4MDFX-ray1.73A/B1-170[»]
4QM6X-ray1.50A/B1-170[»]
4QM7X-ray1.80A/B1-170[»]
ProteinModelPortaliA3DJ38.
SMRiA3DJ38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60067N.
STRINGi203119.Cthe_2768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN53967; ABN53967; Cthe_2768.
KEGGicth:Cthe_2768.
PATRICi19519588. VBICloThe47081_2947.

Phylogenomic databases

eggNOGiENOG4107S1Q. Bacteria.
COG0639. LUCA.
COG4639. LUCA.
HOGENOMiHOG000245786.
KOiK01090.
OMAiVCEEKHM.
OrthoDBiPOG091H03NB.

Enzyme and pathway databases

BRENDAi2.7.1.78. 1530.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR027417. P-loop_NTPase.
IPR024028. PNKP_bac.
IPR032390. PNKP_C.
IPR032380. PNKP_ligase_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16536. PNKP-ligase_C. 1 hit.
PF16542. PNKP_ligase. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR04075. bacter_Pnkp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA3DJ38_CLOTH
AccessioniPrimary (citable) accession number: A3DJ38
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.