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A3DJ37

- A3DJ37_CLOTH

UniProt

A3DJ37 - A3DJ37_CLOTH

Protein
Submitted name:

Methyltransferase type 12

Gene

Cthe_2767

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. O-methyltransferase activity Source: InterPro
    2. RNA methyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-2868-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methyltransferase type 12Imported
    Gene namesi
    Ordered Locus Names:Cthe_2767Imported
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)Imported
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60068N.
    STRINGi203119.Cthe_2767.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JWGX-ray1.90A258-465[»]
    3JWIX-ray2.20A/B259-465[»]
    4DQZX-ray2.30A/B1-230[»]
    4DRFX-ray2.60B/D1-230[»]
    4E6NX-ray2.39B/D1-230[»]
    ProteinModelPortaliA3DJ37.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA3DJ37.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG77126.
    HOGENOMiHOG000245785.
    OMAiEATEERC.
    OrthoDBiEOG6GFGH8.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR024026. 3'-RNA_MeTfrase_Hen1_bac.
    IPR026610. Hen1.
    IPR024740. Hen1_N.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR21404. PTHR21404. 1 hit.
    PfamiPF12623. Hen1_L. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR04074. bacter_Hen1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3DJ37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILTITYTQP PATDLGYLLH KNPSRPQTFE LNHGKAHIFY PEATSERCTV    50
    ALLLDIDPID LARGKKGSSG EGGLFDYVND RPYVSSSFMS VAISRVFGTA 100
    MSGKCKEKPE LAAIKLPLKA KIMMLPCKGG EEIIYRLFEP LGYKVDVEGY 150
    MLDEKFPEWG KSRYYTVSLE GEVRVRDLLN HIYVLIPVLD SEKHYWVGED 200
    EIDKLFQHGE GWLVDHPEKE LITGRYLIRK KRLVNQALKR LLEASDVVDD 250
    ENEDDEPLKN EETEKKLNLN QQRLGTVVAV LKSVNAKKVI DLGCGEGNLL 300
    SLLLKDKSFE QITGVDVSYS VLERAKDRLK IDRLPEMQRK RISLFQSSLV 350
    YRDKRFSGYD AATVIEVIEH LDENRLQAFE KVLFEFTRPQ TVIVSTPNKE 400
    YNFHYQNLFE GNLRHRDHRF EWTRKEFETW AVKVAEKYGY SVRFLQIGEI 450
    DDEFGSPTQM GVFTL 465
    Length:465
    Mass (Da):53,576
    Last modified:March 20, 2007 - v1
    Checksum:i6BAD46C5FAA7D220
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53966.1.
    RefSeqiYP_001039159.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN53966; ABN53966; Cthe_2767.
    GeneIDi4810084.
    KEGGicth:Cthe_2767.
    PATRICi19519586. VBICloThe47081_2946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53966.1 .
    RefSeqi YP_001039159.1. NC_009012.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JWG X-ray 1.90 A 258-465 [» ]
    3JWI X-ray 2.20 A/B 259-465 [» ]
    4DQZ X-ray 2.30 A/B 1-230 [» ]
    4DRF X-ray 2.60 B/D 1-230 [» ]
    4E6N X-ray 2.39 B/D 1-230 [» ]
    ProteinModelPortali A3DJ37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60068N.
    STRINGi 203119.Cthe_2767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN53966 ; ABN53966 ; Cthe_2767 .
    GeneIDi 4810084.
    KEGGi cth:Cthe_2767.
    PATRICi 19519586. VBICloThe47081_2946.

    Phylogenomic databases

    eggNOGi NOG77126.
    HOGENOMi HOG000245785.
    OMAi EATEERC.
    OrthoDBi EOG6GFGH8.

    Enzyme and pathway databases

    BioCyci CTHE203119:GIW8-2868-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei A3DJ37.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR024026. 3'-RNA_MeTfrase_Hen1_bac.
    IPR026610. Hen1.
    IPR024740. Hen1_N.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR21404. PTHR21404. 1 hit.
    Pfami PF12623. Hen1_L. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR04074. bacter_Hen1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372Imported.
    2. "Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1."
      Mui Chan C., Zhou C., Brunzelle J.S., Huang R.H.
      Proc. Natl. Acad. Sci. U.S.A. 106:17699-17704(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 258-465.
    3. "Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair."
      Wang P., Chan C.M., Christensen D., Zhang C., Selvadurai K., Huang R.H.
      Proc. Natl. Acad. Sci. U.S.A. 109:13248-13253(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-230.

    Entry informationi

    Entry nameiA3DJ37_CLOTH
    AccessioniPrimary (citable) accession number: A3DJ37
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3