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A3DJ10

- CLPP_CLOTH

UniProt

A3DJ10 - CLPP_CLOTH

Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophileUniRule annotation
    Active sitei123 – 1231UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-2838-MONOMER.

    Protein family/group databases

    MEROPSiS14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase ClpUniRule annotation
    Gene namesi
    Name:clpPUniRule annotation
    Ordered Locus Names:Cthe_2740
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194ATP-dependent Clp protease proteolytic subunitPRO_1000026087Add
    BLAST

    Interactioni

    Subunit structurei

    Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi203119.Cthe_2740.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DJ10.
    SMRiA3DJ10. Positions 2-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0740.
    HOGENOMiHOG000285833.
    KOiK01358.
    OMAiLIDGIME.
    OrthoDBiEOG6Z3KQ0.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    TIGRFAMsiTIGR00493. clpP. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3DJ10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLVPIVVEQ TNRGERSYDI YSRLLKDRII VLSDEINDVT ASLVVAQMLF    50
    LEAEDPDKDI QLYINSPGGS VTAGFAIYDT MQYVKPDVST ICIGMAASMG 100
    AFLLAAGAKG KRFALPNSEI MIHQPLGGAR GQATDIKIHA EQIIKIKNKL 150
    NRILSERTGQ PFEKIERDTE RDFFMSAEEA KAYGIVDEVM ERRK 194
    Length:194
    Mass (Da):21,601
    Last modified:March 20, 2007 - v1
    Checksum:iB477610D170BB77A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53939.1.
    RefSeqiYP_001039132.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN53939; ABN53939; Cthe_2740.
    GeneIDi4810242.
    KEGGicth:Cthe_2740.
    PATRICi19519522. VBICloThe47081_2914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53939.1 .
    RefSeqi YP_001039132.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali A3DJ10.
    SMRi A3DJ10. Positions 2-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_2740.

    Protein family/group databases

    MEROPSi S14.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN53939 ; ABN53939 ; Cthe_2740 .
    GeneIDi 4810242.
    KEGGi cth:Cthe_2740.
    PATRICi 19519522. VBICloThe47081_2914.

    Phylogenomic databases

    eggNOGi COG0740.
    HOGENOMi HOG000285833.
    KOi K01358.
    OMAi LIDGIME.
    OrthoDBi EOG6Z3KQ0.

    Enzyme and pathway databases

    BioCyci CTHE203119:GIW8-2838-MONOMER.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    TIGRFAMsi TIGR00493. clpP. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiCLPP_CLOTH
    AccessioniPrimary (citable) accession number: A3DJ10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3