Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2857-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Cthe_2724
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003003031 – 1250DNA-directed RNA polymerase subunit betaAdd BLAST1250

Proteomic databases

PRIDEiA3DIZ4

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi203119.Cthe_2724

Structurei

3D structure databases

ProteinModelPortaliA3DIZ4
SMRiA3DIZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ Bacteria
COG0085 LUCA
HOGENOMiHOG000218611
KOiK03043
OMAiFMTWEGY
OrthoDBiPOG091H01MI

Family and domain databases

CDDicd00653 RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 2 hits
2.40.50.150, 1 hit
HAMAPiMF_01321 RNApol_bact_RpoB, 1 hit
InterProiView protein in InterPro
IPR019462 DNA-dir_RNA_pol_bsu_external_1
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR010243 RNA_pol_bsu_bac
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR007642 RNA_pol_Rpb2_2
IPR007645 RNA_pol_Rpb2_3
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856 PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04561 RNA_pol_Rpb2_2, 2 hits
PF04565 RNA_pol_Rpb2_3, 1 hit
PF10385 RNA_pol_Rpb2_45, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit
TIGRFAMsiTIGR02013 rpoB, 1 hit
PROSITEiView protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

A3DIZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHPVKLGRN VRMSYSKIDE VIDMPNLIEI QKNSYEQFLK EGFKEVFKDV
60 70 80 90 100
NPITDYTGNL ILEFVDYSLD EPPKYSVDEC KERDATYAAP LKVKVRLINK
110 120 130 140 150
ETGEVKEQEI FMGDFPLMTE TGTFIINGAE RVIVSQLVRS PGIYYAMKID
160 170 180 190 200
KAGKQLFSNT VIPNRGAWLE YETDSNDVLS VRIDRTRKLP LTVLVRALGY
210 220 230 240 250
GTDLEITELF GEDERILATI QKDSTKTEEE GLLEIYKRLR PGEPPTVESA
260 270 280 290 300
KALLHGLFFD PKRYDLAKPG RFKFNKKLSI AARIHGFIAG ENIKDPDTGE
310 320 330 340 350
IIVAEGETIS REKAETIQNA GVNTVILRVD GKNVKVIGND MVDIKRYVDF
360 370 380 390 400
DPKEIGINEK VKRDVLMEIL EEYKGKGDDA IKKALQERID DLIPKHITKE
410 420 430 440 450
DIISSISYII GLSYGIGSTD DIDHLGNRRL RSVGELLQNQ FRIGLSRMER
460 470 480 490 500
VVRERMTIQD LDVVTPQALI NIRPVAAAIK EFFGSSQLSQ FMDQTNPLAE
510 520 530 540 550
LTHKRRLSAL GPGGLSRERA GFEVRDVHHS HYGRMCPIET PEGPNIGLIG
560 570 580 590 600
SLSTYARVNE YGFIETPYRK VSKEEPGKVT NEIVYLTADE EDEYIIAQAN
610 620 630 640 650
EPLDEEGRFI SNKVVCRYKE EFIEVDPSKI DFMDVSPKQI VSVATSMIPF
660 670 680 690 700
LENDDANRAL MGANMQRQAV PLIKTESPIV GTGIEYRAAR DSGVVILAKN
710 720 730 740 750
PGVVEKVTAN EIIIRTKDGK RDTYKLLKYM RSNQGTCINQ RPIVKKGEEV
760 770 780 790 800
EAGDVIADGP STDNGEIALG KNVLVGFMTW EGYNYEDAIL ISERLVKDDV
810 820 830 840 850
FTSIHIEEYE AEARDTKLGP EDITREIPNV SEDALKDLNS EGIIRIGAEV
860 870 880 890 900
RAGDILVGKV TPKGETELTA EERLLRAIFG EKAREVRDTS LRVPHGESGI
910 920 930 940 950
VVDVKIFTRE NGDELAPGVN KLVRVYVAQK RKISVGDKMA GRHGNKGVIS
960 970 980 990 1000
RILPVEDMPF LPDGTPLDIV LNPLGVPSRM NIGQVLEVHL GYAAKALGWK
1010 1020 1030 1040 1050
VATPVFDGAT EEDIVQTLRK AGLAEDGKSI LYDGRTGEPF ENRVTVGYMY
1060 1070 1080 1090 1100
MLKLAHLVDD KIHARSTGPY SLVTQQPLGG KAQFGGQRFG EMEVWALEAY
1110 1120 1130 1140 1150
GAAYTLQEIL TVKSDDVVGR VKTYEAIVKG ENVPEPGIPE CFKVLIKELQ
1160 1170 1180 1190 1200
SLCLDVKVYS EEQEEIAIKE SVEDDLEELN VNIEGREDEV NFNEFNDIGE
1210 1220 1230 1240 1250
EITDEDLEVE DFDLQDLNDD DINPDDTIDA ELDDNLFDDD FDDTFDDDDL
Length:1,250
Mass (Da):139,956
Last modified:March 20, 2007 - v1
Checksum:i720D2122326EAFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53923.1
RefSeqiWP_020457900.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53923; ABN53923; Cthe_2724
GeneIDi35802901
KEGGicth:Cthe_2724

Similar proteinsi

Entry informationi

Entry nameiRPOB_CLOTH
AccessioniPrimary (citable) accession number: A3DIZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health