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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Cthe_2724
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003003031 – 1250DNA-directed RNA polymerase subunit betaAdd BLAST1250

Proteomic databases

PRIDEiA3DIZ4.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi203119.Cthe_2724.

Structurei

3D structure databases

ProteinModelPortaliA3DIZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DIZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHPVKLGRN VRMSYSKIDE VIDMPNLIEI QKNSYEQFLK EGFKEVFKDV
60 70 80 90 100
NPITDYTGNL ILEFVDYSLD EPPKYSVDEC KERDATYAAP LKVKVRLINK
110 120 130 140 150
ETGEVKEQEI FMGDFPLMTE TGTFIINGAE RVIVSQLVRS PGIYYAMKID
160 170 180 190 200
KAGKQLFSNT VIPNRGAWLE YETDSNDVLS VRIDRTRKLP LTVLVRALGY
210 220 230 240 250
GTDLEITELF GEDERILATI QKDSTKTEEE GLLEIYKRLR PGEPPTVESA
260 270 280 290 300
KALLHGLFFD PKRYDLAKPG RFKFNKKLSI AARIHGFIAG ENIKDPDTGE
310 320 330 340 350
IIVAEGETIS REKAETIQNA GVNTVILRVD GKNVKVIGND MVDIKRYVDF
360 370 380 390 400
DPKEIGINEK VKRDVLMEIL EEYKGKGDDA IKKALQERID DLIPKHITKE
410 420 430 440 450
DIISSISYII GLSYGIGSTD DIDHLGNRRL RSVGELLQNQ FRIGLSRMER
460 470 480 490 500
VVRERMTIQD LDVVTPQALI NIRPVAAAIK EFFGSSQLSQ FMDQTNPLAE
510 520 530 540 550
LTHKRRLSAL GPGGLSRERA GFEVRDVHHS HYGRMCPIET PEGPNIGLIG
560 570 580 590 600
SLSTYARVNE YGFIETPYRK VSKEEPGKVT NEIVYLTADE EDEYIIAQAN
610 620 630 640 650
EPLDEEGRFI SNKVVCRYKE EFIEVDPSKI DFMDVSPKQI VSVATSMIPF
660 670 680 690 700
LENDDANRAL MGANMQRQAV PLIKTESPIV GTGIEYRAAR DSGVVILAKN
710 720 730 740 750
PGVVEKVTAN EIIIRTKDGK RDTYKLLKYM RSNQGTCINQ RPIVKKGEEV
760 770 780 790 800
EAGDVIADGP STDNGEIALG KNVLVGFMTW EGYNYEDAIL ISERLVKDDV
810 820 830 840 850
FTSIHIEEYE AEARDTKLGP EDITREIPNV SEDALKDLNS EGIIRIGAEV
860 870 880 890 900
RAGDILVGKV TPKGETELTA EERLLRAIFG EKAREVRDTS LRVPHGESGI
910 920 930 940 950
VVDVKIFTRE NGDELAPGVN KLVRVYVAQK RKISVGDKMA GRHGNKGVIS
960 970 980 990 1000
RILPVEDMPF LPDGTPLDIV LNPLGVPSRM NIGQVLEVHL GYAAKALGWK
1010 1020 1030 1040 1050
VATPVFDGAT EEDIVQTLRK AGLAEDGKSI LYDGRTGEPF ENRVTVGYMY
1060 1070 1080 1090 1100
MLKLAHLVDD KIHARSTGPY SLVTQQPLGG KAQFGGQRFG EMEVWALEAY
1110 1120 1130 1140 1150
GAAYTLQEIL TVKSDDVVGR VKTYEAIVKG ENVPEPGIPE CFKVLIKELQ
1160 1170 1180 1190 1200
SLCLDVKVYS EEQEEIAIKE SVEDDLEELN VNIEGREDEV NFNEFNDIGE
1210 1220 1230 1240 1250
EITDEDLEVE DFDLQDLNDD DINPDDTIDA ELDDNLFDDD FDDTFDDDDL
Length:1,250
Mass (Da):139,956
Last modified:March 20, 2007 - v1
Checksum:i720D2122326EAFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53923.1.
RefSeqiWP_020457900.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN53923; ABN53923; Cthe_2724.
KEGGicth:Cthe_2724.
PATRICi19519490. VBICloThe47081_2898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53923.1.
RefSeqiWP_020457900.1. NC_009012.1.

3D structure databases

ProteinModelPortaliA3DIZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203119.Cthe_2724.

Proteomic databases

PRIDEiA3DIZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN53923; ABN53923; Cthe_2724.
KEGGicth:Cthe_2724.
PATRICi19519490. VBICloThe47081_2898.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_CLOTH
AccessioniPrimary (citable) accession number: A3DIZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.