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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2509-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Cthe_2399
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005221 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiA3DI22

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_2399

Structurei

3D structure databases

ProteinModelPortaliA3DI22
SMRiA3DI22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3DI22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDIQIAQS CKMKPITQVA AELGIDEEEL ELYGKYKAKL SDKLWERVKD
60 70 80 90 100
RPDGKLVLVT AINPTPAGEG KTTTTVGLGQ AMARIGKKAV IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYSQVVPME DINLHFTGDM HAITAANNLL SAAIDNHIQQ
160 170 180 190 200
GNELNIDVRQ IIWKRAMDMN DRALRNIVVG LGGKANGVPR EDGFQITVAS
210 220 230 240 250
EVMAVLCLST GLMDLKERLG RILIGYTYDG KPVFAKDLKV NGAMALLLKD
260 270 280 290 300
AIKPNLVQTL ENTPAIVHGG PFANIAHGCN SIVATRLGLK LADYCITEAG
310 320 330 340 350
FGADLGAEKF FNIKCRYAGL KPDLVVLVAT IRALKYNGGV KKENLGIENL
360 370 380 390 400
PALEKGFVNL EKHIENIRKF QVPLLVAINH FDTDSEAEIE YVKNRCKALN
410 420 430 440 450
VEVAFSDVFS KGSEGGIELA EKVVKLTETQ KSNFKPLYDV NLSIREKIEI
460 470 480 490 500
IAREIYGADS VNILPAAERA IKKIEELKMD KLPICVAKTQ YSLSDDPTLL
510 520 530 540 550
GRPQGFVITV REIKLSSGAG FIVAITGDIM TMPGLPKVPA AEKIDIDENG

VITGLF
Length:556
Mass (Da):60,199
Last modified:March 20, 2007 - v1
Checksum:i69D406E74CC79253
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53601.1
RefSeqiWP_003516448.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53601; ABN53601; Cthe_2399
GeneIDi35804996
KEGGicth:Cthe_2399

Similar proteinsi

Entry informationi

Entry nameiFTHS_CLOTH
AccessioniPrimary (citable) accession number: A3DI22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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