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A3DI22

- FTHS_CLOTH

UniProt

A3DI22 - FTHS_CLOTH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-2476-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Cthe_2399
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300522Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_2399.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DI22.
    SMRiA3DI22. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3DI22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTDIQIAQS CKMKPITQVA AELGIDEEEL ELYGKYKAKL SDKLWERVKD    50
    RPDGKLVLVT AINPTPAGEG KTTTTVGLGQ AMARIGKKAV IALREPSLGP 100
    VMGIKGGAAG GGYSQVVPME DINLHFTGDM HAITAANNLL SAAIDNHIQQ 150
    GNELNIDVRQ IIWKRAMDMN DRALRNIVVG LGGKANGVPR EDGFQITVAS 200
    EVMAVLCLST GLMDLKERLG RILIGYTYDG KPVFAKDLKV NGAMALLLKD 250
    AIKPNLVQTL ENTPAIVHGG PFANIAHGCN SIVATRLGLK LADYCITEAG 300
    FGADLGAEKF FNIKCRYAGL KPDLVVLVAT IRALKYNGGV KKENLGIENL 350
    PALEKGFVNL EKHIENIRKF QVPLLVAINH FDTDSEAEIE YVKNRCKALN 400
    VEVAFSDVFS KGSEGGIELA EKVVKLTETQ KSNFKPLYDV NLSIREKIEI 450
    IAREIYGADS VNILPAAERA IKKIEELKMD KLPICVAKTQ YSLSDDPTLL 500
    GRPQGFVITV REIKLSSGAG FIVAITGDIM TMPGLPKVPA AEKIDIDENG 550
    VITGLF 556
    Length:556
    Mass (Da):60,199
    Last modified:March 20, 2007 - v1
    Checksum:i69D406E74CC79253
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53601.1.
    RefSeqiYP_001038794.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN53601; ABN53601; Cthe_2399.
    GeneIDi4811051.
    KEGGicth:Cthe_2399.
    PATRICi19518782. VBICloThe47081_2553.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN53601.1 .
    RefSeqi YP_001038794.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali A3DI22.
    SMRi A3DI22. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_2399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN53601 ; ABN53601 ; Cthe_2399 .
    GeneIDi 4811051.
    KEGGi cth:Cthe_2399.
    PATRICi 19518782. VBICloThe47081_2553.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CTHE203119:GIW8-2476-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiFTHS_CLOTH
    AccessioniPrimary (citable) accession number: A3DI22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3