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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-2449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecFUniRule annotation
Gene namesi
Name:recFUniRule annotation
Ordered Locus Names:Cthe_2374
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369DNA replication and repair protein RecFPRO_1000048516Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_2374.

Structurei

3D structure databases

ProteinModelPortaliA3DHZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269559.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DHZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIDRILLKN FRNYKDETIK FSKNLNIIYG QNAQGKTNII EAVFLCASGR
60 70 80 90 100
SHRTSKDTEL VNIDGTGFSV LLDLESSEGR KKIEIDYECG KKKVVKINEI
110 120 130 140 150
PLKKIGNLMG NLLAVIFSPE DILIIKEGPS ERRRFIDITL CQLKPSYFYD
160 170 180 190 200
LQQYNKVLSQ RNMLLKEIQY KRNLLDTLEV WDYKMAELSS RIMTTRSEFI
210 220 230 240 250
KRLCEISKKI HLKLTDGSEI MEIKYSPSVD LHDLSNPSEI KNEFIRQLNS
260 270 280 290 300
IRDIELKRCV TLIGPHRDDY EMELNGLNLK MFGSQGQQRT SLLSLKLAEI
310 320 330 340 350
EIIKSETDED PVLLLDDVMS ELDFKRREFL LENIRNVQTF ITCTDKELFE
360
NRNFGDNLYI RVEAGRTYY
Length:369
Mass (Da):43,087
Last modified:March 20, 2007 - v1
Checksum:i489710FF83183761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53576.1.
RefSeqiWP_003513335.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN53576; ABN53576; Cthe_2374.
KEGGicth:Cthe_2374.
PATRICi19518724. VBICloThe47081_2526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN53576.1.
RefSeqiWP_003513335.1. NC_009012.1.

3D structure databases

ProteinModelPortaliA3DHZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203119.Cthe_2374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN53576; ABN53576; Cthe_2374.
KEGGicth:Cthe_2374.
PATRICi19518724. VBICloThe47081_2526.

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269559.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-2449-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

Entry informationi

Entry nameiRECF_CLOTH
AccessioniPrimary (citable) accession number: A3DHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: April 13, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.