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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, DNA replication, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2481-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecFUniRule annotation
Gene namesi
Name:recFUniRule annotation
Ordered Locus Names:Cthe_2374
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000485161 – 369DNA replication and repair protein RecFAdd BLAST369

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_2374

Structurei

3D structure databases

ProteinModelPortaliA3DHZ7
SMRiA3DHZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3X Bacteria
COG1195 LUCA
HOGENOMiHOG000269559
KOiK03629
OMAiGQQKSFL
OrthoDBiPOG091H00U7

Family and domain databases

HAMAPiMF_00365 RecF, 1 hit
InterProiView protein in InterPro
IPR001238 DNA-binding_RecF
IPR018078 DNA-binding_RecF_CS
IPR027417 P-loop_NTPase
IPR038729 Rad50/SbcC_AAA
PANTHERiPTHR32182:SF0 PTHR32182:SF0, 1 hit
PfamiView protein in Pfam
PF13476 AAA_23, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00611 recf, 1 hit
PROSITEiView protein in PROSITE
PS00617 RECF_1, 1 hit
PS00618 RECF_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3DHZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIDRILLKN FRNYKDETIK FSKNLNIIYG QNAQGKTNII EAVFLCASGR
60 70 80 90 100
SHRTSKDTEL VNIDGTGFSV LLDLESSEGR KKIEIDYECG KKKVVKINEI
110 120 130 140 150
PLKKIGNLMG NLLAVIFSPE DILIIKEGPS ERRRFIDITL CQLKPSYFYD
160 170 180 190 200
LQQYNKVLSQ RNMLLKEIQY KRNLLDTLEV WDYKMAELSS RIMTTRSEFI
210 220 230 240 250
KRLCEISKKI HLKLTDGSEI MEIKYSPSVD LHDLSNPSEI KNEFIRQLNS
260 270 280 290 300
IRDIELKRCV TLIGPHRDDY EMELNGLNLK MFGSQGQQRT SLLSLKLAEI
310 320 330 340 350
EIIKSETDED PVLLLDDVMS ELDFKRREFL LENIRNVQTF ITCTDKELFE
360
NRNFGDNLYI RVEAGRTYY
Length:369
Mass (Da):43,087
Last modified:March 20, 2007 - v1
Checksum:i489710FF83183761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53576.1
RefSeqiWP_003513335.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53576; ABN53576; Cthe_2374
GeneIDi35803368
KEGGicth:Cthe_2374

Similar proteinsi

Entry informationi

Entry nameiRECF_CLOTH
AccessioniPrimary (citable) accession number: A3DHZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health