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A3DGS4

- SYR_CLOTH

UniProt

A3DGS4 - SYR_CLOTH

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Protein
Arginine--tRNA ligase
Gene
argS, Cthe_1935
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-1998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:Cthe_1935
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
ProteomesiUP000002145: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Arginine--tRNA ligaseUniRule annotation
PRO_1000018018Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi203119.Cthe_1935.

Structurei

3D structure databases

ProteinModelPortaliA3DGS4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi136 – 14611"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLCNVLAK.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DGS4-1 [UniParc]FASTAAdd to Basket

« Hide

MTNVVETIKK QINEVVKNSI SKAVQNGELP QFTVDELFIE IPKEKGHGDF    50
STNIAMQAAK TVRKAPRQVA EIIIKNMDLS NTYIDRVEAA GPGFINFFLT 100
NAWLYDVLKV IQKEKENYGN LDIGRGQKVM VEFVSANPTG PLHMGNARGG 150
ALGDCIASVL EKAGYDVTRE FYINDAGNQI EKFGISLEAR YIQLLKGEDA 200
VEFPEDGYHG EDIIDHMKAY IEENGDNLLY VDSEERRKTL VEYALPKNIE 250
RIRKSLENYG VVFDVWFSEQ SLYDNGEVRE TLDILKEKGY TFEKDGAVWF 300
KASALGAEKD EVIVRNNGIP TYFAADIAYH RNKFLKRKFD RVINLLGADH 350
HGHAARMKCA LKAFDIDPDK LDIVIFQLVR LYRNGEIARM SKRTGRAISL 400
DDLLEEVGRD AARFFFNTKA SGSHLDFDLD LAVKKSNENP VYYVQYAYAR 450
SCSMLRLLES EGFKVPDVDS VDLTVLKAPE EIELMKKLSE YPEEIRISAQ 500
TLEPSRLTRY VLDVASNFHS FYNACRVKGE EENLMYARMI LVDSTRLVIK 550
NVLDVLSITA PEKM 564
Length:564
Mass (Da):64,037
Last modified:March 20, 2007 - v1
Checksum:iF8ECCD56DB1AA228
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000568 Genomic DNA. Translation: ABN53153.1.
RefSeqiYP_001038346.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN53153; ABN53153; Cthe_1935.
GeneIDi4810793.
KEGGicth:Cthe_1935.
PATRICi19517753. VBICloThe47081_2050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000568 Genomic DNA. Translation: ABN53153.1 .
RefSeqi YP_001038346.1. NC_009012.1.

3D structure databases

ProteinModelPortali A3DGS4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203119.Cthe_1935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN53153 ; ABN53153 ; Cthe_1935 .
GeneIDi 4810793.
KEGGi cth:Cthe_1935.
PATRICi 19517753. VBICloThe47081_2050.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247214.
KOi K01887.
OMAi LCNVLAK.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci CTHE203119:GIW8-1998-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27405 / DSM 1237.

Entry informationi

Entry nameiSYR_CLOTH
AccessioniPrimary (citable) accession number: A3DGS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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