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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2017-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Cthe_1935
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000180181 – 564Arginine--tRNA ligaseAdd BLAST564

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi203119.Cthe_1935

Structurei

3D structure databases

ProteinModelPortaliA3DGS4
SMRiA3DGS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 146"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247214
KOiK01887
OMAiHGMSTRQ
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A3DGS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVVETIKK QINEVVKNSI SKAVQNGELP QFTVDELFIE IPKEKGHGDF
60 70 80 90 100
STNIAMQAAK TVRKAPRQVA EIIIKNMDLS NTYIDRVEAA GPGFINFFLT
110 120 130 140 150
NAWLYDVLKV IQKEKENYGN LDIGRGQKVM VEFVSANPTG PLHMGNARGG
160 170 180 190 200
ALGDCIASVL EKAGYDVTRE FYINDAGNQI EKFGISLEAR YIQLLKGEDA
210 220 230 240 250
VEFPEDGYHG EDIIDHMKAY IEENGDNLLY VDSEERRKTL VEYALPKNIE
260 270 280 290 300
RIRKSLENYG VVFDVWFSEQ SLYDNGEVRE TLDILKEKGY TFEKDGAVWF
310 320 330 340 350
KASALGAEKD EVIVRNNGIP TYFAADIAYH RNKFLKRKFD RVINLLGADH
360 370 380 390 400
HGHAARMKCA LKAFDIDPDK LDIVIFQLVR LYRNGEIARM SKRTGRAISL
410 420 430 440 450
DDLLEEVGRD AARFFFNTKA SGSHLDFDLD LAVKKSNENP VYYVQYAYAR
460 470 480 490 500
SCSMLRLLES EGFKVPDVDS VDLTVLKAPE EIELMKKLSE YPEEIRISAQ
510 520 530 540 550
TLEPSRLTRY VLDVASNFHS FYNACRVKGE EENLMYARMI LVDSTRLVIK
560
NVLDVLSITA PEKM
Length:564
Mass (Da):64,037
Last modified:March 20, 2007 - v1
Checksum:iF8ECCD56DB1AA228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53153.1
RefSeqiWP_003513911.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53153; ABN53153; Cthe_1935
GeneIDi35806233
KEGGicth:Cthe_1935

Entry informationi

Entry nameiSYR_CLOTH
AccessioniPrimary (citable) accession number: A3DGS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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