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Protein

Urease subunit beta

Gene

ureB

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-1892-MONOMER
UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit betaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit betaUniRule annotation
Gene namesi
Name:ureBUniRule annotation
Ordered Locus Names:Cthe_1817
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000707311 – 122Urease subunit betaAdd BLAST122

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi203119.Cthe_1817

Structurei

3D structure databases

ProteinModelPortaliA3DGF9
SMRiA3DGF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KI2 Bacteria
COG0832 LUCA
HOGENOMiHOG000077770
KOiK01429
OMAiHFAETNA
OrthoDBiPOG091H08S9

Family and domain databases

CDDicd00407 Urease_beta, 1 hit
Gene3Di2.10.150.10, 1 hit
HAMAPiMF_01954 Urease_beta, 1 hit
InterProiView protein in InterPro
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
PfamiView protein in Pfam
PF00699 Urease_beta, 1 hit
SUPFAMiSSF51278 SSF51278, 1 hit
TIGRFAMsiTIGR00192 urease_beta, 1 hit

Sequencei

Sequence statusi: Complete.

A3DGF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGEYIIKN EFITLNDGRR TLNIKVSNTG DRPVQVGSHY HFFEVNRYLE
60 70 80 90 100
FDRKSAFGMR LDIPSGTAVR FEPGEEKTVQ LVEIGGSREI YGLNDLTCGP
110 120
LDREDLSNVF KKAKELGFKG VE
Length:122
Mass (Da):13,828
Last modified:March 20, 2007 - v1
Checksum:i6A386D6C39281BF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53038.1
RefSeqiWP_003515807.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53038; ABN53038; Cthe_1817
GeneIDi35804644
KEGGicth:Cthe_1817

Similar proteinsi

Entry informationi

Entry nameiURE2_CLOTH
AccessioniPrimary (citable) accession number: A3DGF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health