A3DFT0 (A3DFT0_CLOTH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 1 HAMAP MF_00114
Short name=DERA 1 HAMAP MF_00114
EC=4.1.2.4 HAMAP MF_00114

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 1 HAMAP MF_00114
Phosphodeoxyriboaldolase 1 HAMAP MF_00114

Gene names

Name:	deoC1 HAMAP MF_00114
Ordered Locus Names:	Cthe_1583

Organism

Clostridium thermocellum (strain ATCC 27405 / DSM 1237) [Complete proteome] [HAMAP]

Taxonomic identifier

203119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114 SAAS SAAS022979
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114 SAAS SAAS022979
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114 SAAS SAAS022979
Subcellular location	Cytoplasm By similarity HAMAP MF_00114 SAAS SAAS022979.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. HAMAP MF_00114

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00114 SAAS SAAS022979
Ligand	Schiff base HAMAP MF_00114 SAAS SAAS022979
Molecular function	Lyase HAMAP MF_00114 SAAS SAAS022979 EMBL ABN52809.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	153	1	Schiff-base intermediate with acetaldehyde By similarity HAMAP MF_00114
	Active site	182	1	By similarity HAMAP MF_00114

Sequences

	Sequence		Length	Mass (Da)
	A3DFT0 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 52AC677B3B75A3C9	FASTA	222	24,401
	10 20 30 40 50 60 MNTQDILSHV DHTLLLQTAT WPEIQALCDD AIKYQTASVC IPPCYVARAK EYVGDRMVIC 70 80 90 100 110 120 TVIGFPNGNM TTAAKVFETQ DAIANGADEI DMVINIGALK NKEYDYVLKE IKAIKQACGE 130 140 150 160 170 180 RILKVIIETC LLTEEEKIVM CDLVTRSGAD YIKTSTGFST AGATFEDIEL FAKHVGPNVK 190 200 210 220 IKAAGGISNF NDARKYIELG ADRLGTSRLV KLMKSQSYDG LY

References

[1]

"Complete sequence of Clostridium thermocellum ATCC 27405." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., Newcomb M., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27405 / DSM 1237.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000568 Genomic DNA. Translation: ABN52809.1.
RefSeq	YP_001038002.1. NC_009012.1.
3D structure databases
ProteinModelPortal	A3DFT0.
ModBase	Search...
Protein-protein interaction databases
STRING	A3DFT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4809574.
GenomeReviews	Gene locus Cthe_1583 in contig CP000568_GR.
KEGG	cth:Cthe_1583.
NMPDR	fig|203119.1.peg.3312.
PATRIC	19517001. VBICloThe47081_1680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	EEKIAMC.
ProtClustDB	PRK00507.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3DFT0_CLOTH

Accession

Primary (citable) accession number: A3DFT0

Entry history

Integrated into UniProtKB/TrEMBL:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)