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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei315Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-1353-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Cthe_1297
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000215861 – 351Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST351

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_1297

Structurei

3D structure databases

ProteinModelPortaliA3DF00
SMRiA3DF00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263499
KOiK00768
OMAiATFGGFE
OrthoDBiPOG091H0031

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

A3DF00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFQTLKSIG ELYKEPMDMV QRRLDSLSKP LGSLGRLEDI IKKLAGITGE
60 70 80 90 100
VFPCVDKKAV IIMCADNGVV EEGISSCPKD VTSKVTRNFL KGITAINAFA
110 120 130 140 150
KHTGSDIVVV DIGVDDDMDC EGIVKRKVRK GTWNIAKGPA MTRKEAIEAI
160 170 180 190 200
EVGISIVEEL GRKGVNLLGT GEMGIGNTTT SSAVSTVLTD SKAENMVGRG
210 220 230 240 250
AGLSDEALKR KISIVKKAID LNRPDANDPI DVVSKVGGFD IAGLAGCFIG
260 270 280 290 300
AAACRIPILI DGFISATAAL AAVRMEPKVK NFIFPSHGSA EPGSKKVMEA
310 320 330 340 350
LGFEPILNLE MRVGEGTGAA LAFHIFDCAV SVYRNMGTFE DACIEQYQPQ

V
Length:351
Mass (Da):37,352
Last modified:March 20, 2007 - v1
Checksum:iBCC497D774030872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN52529.1
RefSeqiWP_003517549.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN52529; ABN52529; Cthe_1297
GeneIDi35805704
KEGGicth:Cthe_1297

Similar proteinsi

Entry informationi

Entry nameiCOBT_CLOTH
AccessioniPrimary (citable) accession number: A3DF00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health