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A3DEU0

- SYL_CLOTH

UniProt

A3DEU0 - SYL_CLOTH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-1287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Cthe_1237
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 825825Leucine--tRNA ligasePRO_1000009331Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_1237.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DEU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3DEU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYNFVDIEK KWQKKWLEEK AFAVREDESK KKYYVLEMFP YPSGNLHMGH    50
    VRNYSIGDVV ARFKRMNGFN VLHPMGWDAF GLPAENAAIK RGVHPNDWTW 100
    SNIDNMRRQL KQLGISYDWD REVATCHPDY YKWTQWMFLQ LYKNGLAYKK 150
    KAYVNWCPSC ATVLANEQVV NGVCERCKSV VGKKDLEQWF FKITDYAQRL 200
    LDDIEKLKGW PDKVKVMQQN WIGRSEGVEV DFKVDGMDKA VRVYTTRPDT 250
    IYGVTYVVIA PEHPVVKELI KGTEQEQVCN EFINKMMFLN EIDRTATDVE 300
    KEGVFTGRYV INPLNGDRVP LYLANYVLAE YGTGVVMAVP AHDQRDFEFA 350
    KKYNLPIKVV IQPEGQELDA SRMTEAFVEV GYLVNSAEFD GVRSDEAIGK 400
    IIDYIEQKGY GKRKINYRLR DWLISRQRYW GAPIPIIYCD DCGAVPVPEE 450
    DLPVILPTDI KFSGVGESPL STSETFISAP CPKCGKMGRR ELDTMDTFVC 500
    SSWYYLRYCD PCNDKAPFDK ERIRYWLPVD QYIGGVEHAI LHLLYSRFLM 550
    KVLYDLGYVD YDEPFTNLLT QGMVLKDGAK MSKSLGNVVS PEEIIEKYGA 600
    DTARLFILFA SPPEKDLEWS DQGVEGCYRF INRVWRIVNE FADAVKEGGN 650
    IDTSTFTKAD KELWYMLNNT LKRVTDDISQ RFNFNTAISA VMELVNSLYY 700
    YKDKVADDSK NKALVREVIE KLIIMLAPFI PHATEELWSA IGKEGSVHEQ 750
    KWPSFDPAAL VKDEIEIVVQ INGKVRDKIV VPSDLTKEQV EERALNSEKI 800
    KAETAGKNVV KVISVPGKLV NIVVK 825
    Length:825
    Mass (Da):94,886
    Last modified:March 20, 2007 - v1
    Checksum:i45416BD31E0D0AEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN52469.1.
    RefSeqiYP_001037662.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN52469; ABN52469; Cthe_1237.
    GeneIDi4809929.
    KEGGicth:Cthe_1237.
    PATRICi19516249. VBICloThe47081_1305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN52469.1 .
    RefSeqi YP_001037662.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali A3DEU0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_1237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN52469 ; ABN52469 ; Cthe_1237 .
    GeneIDi 4809929.
    KEGGi cth:Cthe_1237.
    PATRICi 19516249. VBICloThe47081_1305.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CTHE203119:GIW8-1287-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiSYL_CLOTH
    AccessioniPrimary (citable) accession number: A3DEU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3