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Protein

Elongation factor P

Gene

efp

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.UniRule annotation

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor PUniRule annotation
Short name:
EF-PUniRule annotation
Gene namesi
Name:efpUniRule annotation
Ordered Locus Names:Cthe_0847
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000107241 – 185Elongation factor PAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0847.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi18 – 28Combined sources11
Beta strandi36 – 43Combined sources8
Turni44 – 46Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi66 – 76Combined sources11
Beta strandi79 – 83Combined sources5
Turni85 – 87Combined sources3
Beta strandi90 – 94Combined sources5
Helixi95 – 98Combined sources4
Turni99 – 104Combined sources6
Beta strandi110 – 116Combined sources7
Beta strandi119 – 124Combined sources6
Beta strandi127 – 135Combined sources9
Beta strandi149 – 154Combined sources6
Beta strandi159 – 163Combined sources5
Beta strandi171 – 175Combined sources5
Turni176 – 179Combined sources4
Beta strandi180 – 184Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YBYX-ray1.95A/B1-185[»]
ProteinModelPortaliA3DDQ3.
SMRiA3DDQ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3DDQ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the elongation factor P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDYVFMDM.
OrthoDBiPOG091H028W.

Family and domain databases

CDDicd04470. S1_EF-P_repeat_1. 1 hit.
cd05794. S1_EF-P_repeat_2. 1 hit.
Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DDQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAGDFKNG VTFELDGQIF QVIEFQHVKP GKGAAFVRTK LKNIVTGATI
60 70 80 90 100
EKTFNPTDKM PKAHIERKDM QYLYNDGDLY YFMDTETFEQ LPLGKDKIGD
110 120 130 140 150
ALKFVKENEI VKVLSHKGNV FGIEPPNFVE LEVTDTEPGF KGDTATGATK
160 170 180
PAIVETGASI KVPLFVNKGD IIRIDTRTGE YMERV
Length:185
Mass (Da):20,654
Last modified:March 20, 2007 - v1
Checksum:i0B9E5532C74794FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN52082.1.
RefSeqiWP_003517139.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN52082; ABN52082; Cthe_0847.
KEGGicth:Cthe_0847.
PATRICi19515403. VBICloThe47081_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN52082.1.
RefSeqiWP_003517139.1. NC_009012.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YBYX-ray1.95A/B1-185[»]
ProteinModelPortaliA3DDQ3.
SMRiA3DDQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203119.Cthe_0847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN52082; ABN52082; Cthe_0847.
KEGGicth:Cthe_0847.
PATRICi19515403. VBICloThe47081_0890.

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDYVFMDM.
OrthoDBiPOG091H028W.

Enzyme and pathway databases

UniPathwayiUPA00345.

Miscellaneous databases

EvolutionaryTraceiA3DDQ3.

Family and domain databases

CDDicd04470. S1_EF-P_repeat_1. 1 hit.
cd05794. S1_EF-P_repeat_2. 1 hit.
Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFP_CLOTH
AccessioniPrimary (citable) accession number: A3DDQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.