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Protein

Elongation factor P

Gene

efp

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.UniRule annotation

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-876-MONOMER.
UniPathwayiUPA00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor PUniRule annotation
Short name:
EF-PUniRule annotation
Gene namesi
Name:efpUniRule annotation
Ordered Locus Names:Cthe_0847
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Elongation factor PPRO_1000010724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0847.

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi12 – 154Combined sources
Beta strandi18 – 2811Combined sources
Beta strandi36 – 438Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 546Combined sources
Beta strandi66 – 7611Combined sources
Beta strandi79 – 835Combined sources
Turni85 – 873Combined sources
Beta strandi90 – 945Combined sources
Helixi95 – 984Combined sources
Turni99 – 1046Combined sources
Beta strandi110 – 1167Combined sources
Beta strandi119 – 1246Combined sources
Beta strandi127 – 1359Combined sources
Beta strandi149 – 1546Combined sources
Beta strandi159 – 1635Combined sources
Beta strandi171 – 1755Combined sources
Turni176 – 1794Combined sources
Beta strandi180 – 1845Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YBYX-ray1.95A/B1-185[»]
ProteinModelPortaliA3DDQ3.
SMRiA3DDQ3. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3DDQ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the elongation factor P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDYVFMDM.
OrthoDBiPOG091H028W.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3DDQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAGDFKNG VTFELDGQIF QVIEFQHVKP GKGAAFVRTK LKNIVTGATI
60 70 80 90 100
EKTFNPTDKM PKAHIERKDM QYLYNDGDLY YFMDTETFEQ LPLGKDKIGD
110 120 130 140 150
ALKFVKENEI VKVLSHKGNV FGIEPPNFVE LEVTDTEPGF KGDTATGATK
160 170 180
PAIVETGASI KVPLFVNKGD IIRIDTRTGE YMERV
Length:185
Mass (Da):20,654
Last modified:March 20, 2007 - v1
Checksum:i0B9E5532C74794FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN52082.1.
RefSeqiWP_003517139.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN52082; ABN52082; Cthe_0847.
KEGGicth:Cthe_0847.
PATRICi19515403. VBICloThe47081_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA. Translation: ABN52082.1.
RefSeqiWP_003517139.1. NC_009012.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YBYX-ray1.95A/B1-185[»]
ProteinModelPortaliA3DDQ3.
SMRiA3DDQ3. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203119.Cthe_0847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN52082; ABN52082; Cthe_0847.
KEGGicth:Cthe_0847.
PATRICi19515403. VBICloThe47081_0890.

Phylogenomic databases

eggNOGiENOG4105DRH. Bacteria.
COG0231. LUCA.
HOGENOMiHOG000010047.
KOiK02356.
OMAiDYVFMDM.
OrthoDBiPOG091H028W.

Enzyme and pathway databases

UniPathwayiUPA00345.
BioCyciCTHE203119:GIW8-876-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA3DDQ3.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00141. EF_P. 1 hit.
InterProiIPR015365. Elong-fact-P_C.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR020599. Transl_elong_fac_P/YeiP.
IPR013185. Transl_elong_KOW-like.
IPR001059. Transl_elong_P/YeiP_cen.
IPR013852. Transl_elong_P/YeiP_CS.
IPR011768. Transl_elongation_fac_P.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01132. EFP. 1 hit.
PF08207. EFP_N. 1 hit.
PF09285. Elong-fact-P_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005901. EF-P. 1 hit.
SMARTiSM01185. EFP. 1 hit.
SM00841. Elong-fact-P_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 2 hits.
TIGRFAMsiTIGR00038. efp. 1 hit.
PROSITEiPS01275. EFP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFP_CLOTH
AccessioniPrimary (citable) accession number: A3DDQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.