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Protein

NAD kinase

Gene

nadK

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei73NADUniRule annotation1
Binding sitei153NADUniRule annotation1
Binding sitei172NADUniRule annotation1
Binding sitei243NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi142 – 143NADUniRule annotation2
Nucleotide bindingi183 – 188NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-850-MONOMER
BRENDAi2.6.1.83 1530

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Cthe_0816
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000794851 – 289NAD kinaseAdd BLAST289

Proteomic databases

PRIDEiA3DDM2

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0816

Structurei

3D structure databases

ProteinModelPortaliA3DDM2
SMRiA3DDM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A3DDM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIGIIPNE DKDEELKYTR ILVDSIKKCG GTAIVCDDIA LKLGDKESNI
60 70 80 90 100
NEDNIVDMSD VMVCLGGDGT FLKAARMTVV KGKPLLGVNL GKLGFLADVD
110 120 130 140 150
KNDIENAVKR LVEDKFTVDE RMMLDTVIVR DGKIIAEDIV LNDVVISRGA
160 170 180 190 200
ISRILHLKTY INDAFMDLYP GDGLIISTPT GSTAYSLSAG GPLVEPDVDL
210 220 230 240 250
IICTPICPHL LYSRSFITTA DRVIKVVVAE SSSHEAMVTV DGQNGYEVRG
260 270 280
GDVIITKKSR IRMPMVRLNG KNFFDVLRGK IYDRGESMK
Length:289
Mass (Da):31,670
Last modified:March 20, 2007 - v1
Checksum:iAF95C884EB114B6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN52051.1
RefSeqiWP_003518725.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN52051; ABN52051; Cthe_0816
GeneIDi35803656
KEGGicth:Cthe_0816

Similar proteinsi

Entry informationi

Entry nameiNADK_CLOTH
AccessioniPrimary (citable) accession number: A3DDM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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