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Protein

Chorismate mutase AroH

Gene

Cthe_0711

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.UniRule annotation

Catalytic activityi

Chorismate = prephenate.UniRule annotation

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Chorismate mutase AroH (Cthe_0711)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei6SubstrateUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei114SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-745-MONOMER
UniPathwayiUPA00120; UER00203

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate mutase AroHUniRule annotation (EC:5.4.99.5UniRule annotation)
Gene namesi
Ordered Locus Names:Cthe_0711Imported
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)Imported
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0711

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHOX-ray2.20A/B/C1-118[»]
ProteinModelPortaliA3DDB7
SMRiA3DDB7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA3DDB7

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105KHN Bacteria
COG4401 LUCA
HOGENOMiHOG000043606
KOiK06208
OMAiCIRVMMT
OrthoDBiPOG091H0FMF

Family and domain databases

CDDicd02185 AroH, 1 hit
Gene3Di3.30.1330.40, 1 hit
InterProiView protein in InterPro
IPR008243 Chorismate_mutase_AroH
IPR035959 RutC-like_sf
PANTHERiPTHR21164 PTHR21164, 1 hit
PfamiView protein in Pfam
PF07736 CM_1, 1 hit
PIRSFiPIRSF005965 Chor_mut_AroH, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD031888 Chorismate_mutase_AroH, 1 hit
SUPFAMiSSF55298 SSF55298, 1 hit
TIGRFAMsiTIGR01796 CM_mono_aroH, 1 hit
PROSITEiView protein in PROSITE
PS51167 CHORISMATE_MUT_1, 1 hit

Sequencei

Sequence statusi: Complete.

A3DDB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWAIRGATT VSDNTADEIV AETQKLLKEM AEKNGLEEDD IISIIFTVTK
60 70 80 90 100
DLDAAFPAIA ARNMGWTSTA LMCMNEIDVP GSLEKCIRVM MHVNTDKDKK
110
DIKHVYLNGA KVLRPDLT
Length:118
Mass (Da):13,096
Last modified:March 20, 2007 - v1
Checksum:iE015FF82080E3EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN51946.1
RefSeqiWP_003516211.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN51946; ABN51946; Cthe_0711
GeneIDi35803436
KEGGicth:Cthe_0711

Similar proteinsi

Entry informationi

Entry nameiA3DDB7_CLOTH
AccessioniPrimary (citable) accession number: A3DDB7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health