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A3DD67

- A3DD67_CLOTH

UniProt

A3DD67 - A3DD67_CLOTH

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Protein
Submitted name:

Ricin B lectin

Gene

Cthe_0661

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei438 – 4381GalactoseImported

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. polysaccharide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Ligandi

LectinImported

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-685-MONOMER.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
GH43. Glycoside Hydrolase Family 43.

Names & Taxonomyi

Protein namesi
Submitted name:
Ricin B lectinImported
Gene namesi
Ordered Locus Names:Cthe_0661Imported
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)Imported
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
ProteomesiUP000002145: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 PotentialImportedAdd
BLAST
Chaini33 – 571539 PotentialImportedPRO_5000225106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0661.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VSFX-ray2.76A/B/C/D/E/F31-520[»]
3VSZX-ray2.89A/B/C/D/E/F31-520[»]
3VT0X-ray2.91A/B/C/D/E/F31-520[»]
3VT1X-ray3.19A/B/C/D/E/F31-520[»]
3VT2X-ray3.00A/B/C/D/E/F31-520[»]
ProteinModelPortaliA3DD67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni416 – 4205Galactose bindingImported
Regioni431 – 4344Galactose bindingImported

Sequence similaritiesi

Belongs to the glycosyl hydrolase 43 family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000169275.
OMAiANIERPK.
OrthoDBiEOG676Z69.

Family and domain databases

Gene3Di1.10.1330.10. 1 hit.
2.115.10.20. 1 hit.
InterProiIPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR018247. EF_Hand_1_Ca_BS.
IPR006710. Glyco_hydro_43.
IPR023296. Glyco_hydro_beta-prop.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERiPTHR22925. PTHR22925. 1 hit.
PfamiPF00404. Dockerin_1. 2 hits.
PF04616. Glyco_hydro_43. 1 hit.
PF14200. RicinB_lectin_2. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF63446. SSF63446. 1 hit.
SSF75005. SSF75005. 1 hit.
PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3DD67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKKNVGLRF LSILILMALL IGNVQSFNVA AAEGVIVNGT QFKDTSGNVI
60 70 80 90 100
HAHGGGMLKH GDYYYWYGEY RDDSNLFLGV SCYRSKDLVN WEYRGEVLSR
110 120 130 140 150
NSAPELNHCN IERPKVMYNA STGEFVMWMH WENGINYGQA RAAVAYSKTP
160 170 180 190 200
DGKFTYIRSF RPMQDTGVMD HGLPGYMSRD CNVFVDTDGK GYFISAANEN
210 220 230 240 250
MDLHLYELTP DYKNIASLKA KLFVGQQREA PCLIKRNGYY YLITSGCTGW
260 270 280 290 300
NPNQAKYAYS KDLASGWSQL YNLGNSTTYR SQPTFIIPVQ GSSGTSYLYM
310 320 330 340 350
GDRWAGAWGG KVNDSQYVWL PLNFISDTTL ELPYYDSVKI DASSGIISEY
360 370 380 390 400
IPDTTRYKLV NKNSGKVLDV LDGSVDNAAQ IVQWTDNGSL SQQWYLVDVG
410 420 430 440 450
GGYKKIVNVK SGRALDVKDE SKEDGGVLIQ YTSNGGYNQH WKFTDIGDGY
460 470 480 490 500
YKISSRHCGK LIDVRKWSTE DGGIIQQWSD AGGTNQHWKL VLVSSPEPSP
510 520 530 540 550
SPSPQVVKGD VNGDLKVNST DFSMLRRYLL KTIDNFPTEN GKQAADLNGD
560 570
GRINSSDLTM LKRYLLMEVD L
Length:571
Mass (Da):63,895
Last modified:March 20, 2007 - v1
Checksum:i5034D6F32BBA3CA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000568 Genomic DNA. Translation: ABN51896.1.
RefSeqiWP_011837884.1. NC_009012.1.
YP_001037089.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN51896; ABN51896; Cthe_0661.
GeneIDi4808191.
KEGGicth:Cthe_0661.
PATRICi19515007. VBICloThe47081_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000568 Genomic DNA. Translation: ABN51896.1 .
RefSeqi WP_011837884.1. NC_009012.1.
YP_001037089.1. NC_009012.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VSF X-ray 2.76 A/B/C/D/E/F 31-520 [» ]
3VSZ X-ray 2.89 A/B/C/D/E/F 31-520 [» ]
3VT0 X-ray 2.91 A/B/C/D/E/F 31-520 [» ]
3VT1 X-ray 3.19 A/B/C/D/E/F 31-520 [» ]
3VT2 X-ray 3.00 A/B/C/D/E/F 31-520 [» ]
ProteinModelPortali A3DD67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203119.Cthe_0661.

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
GH43. Glycoside Hydrolase Family 43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN51896 ; ABN51896 ; Cthe_0661 .
GeneIDi 4808191.
KEGGi cth:Cthe_0661.
PATRICi 19515007. VBICloThe47081_0694.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000169275.
OMAi ANIERPK.
OrthoDBi EOG676Z69.

Enzyme and pathway databases

BioCyci CTHE203119:GIW8-685-MONOMER.

Family and domain databases

Gene3Di 1.10.1330.10. 1 hit.
2.115.10.20. 1 hit.
InterProi IPR016134. Cellulos_enz_dockerin_1.
IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
IPR018242. Dockerin_1.
IPR018247. EF_Hand_1_Ca_BS.
IPR006710. Glyco_hydro_43.
IPR023296. Glyco_hydro_beta-prop.
IPR000772. Ricin_B_lectin.
[Graphical view ]
PANTHERi PTHR22925. PTHR22925. 1 hit.
Pfami PF00404. Dockerin_1. 2 hits.
PF04616. Glyco_hydro_43. 1 hit.
PF14200. RicinB_lectin_2. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF63446. SSF63446. 1 hit.
SSF75005. SSF75005. 1 hit.
PROSITEi PS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS00018. EF_HAND_1. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372Imported.
  2. "Crystal structure of 1,3Gal43A, an exo-?-1,3-galactanase from Clostridium thermocellum."
    Jiang D., Fan J., Wang X., Zhao Y., Huang B., Liu J., Zhang X.C.
    J. Struct. Biol. 180:447-457(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.76 ANGSTROMS) OF 31-520 IN COMPLEX WITH GALACTOSE.

Entry informationi

Entry nameiA3DD67_CLOTH
AccessioniPrimary (citable) accession number: A3DD67
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3