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A3DD67

- A3DD67_CLOTH

UniProt

A3DD67 - A3DD67_CLOTH

Protein
Submitted name:

Ricin B lectin

Gene

Cthe_0661

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei438 – 4381GalactoseImported

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. polysaccharide catabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Ligandi

    LectinImported

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-685-MONOMER.

    Protein family/group databases

    CAZyiCBM13. Carbohydrate-Binding Module Family 13.
    GH43. Glycoside Hydrolase Family 43.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ricin B lectinImported
    Gene namesi
    Ordered Locus Names:Cthe_0661Imported
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)Imported
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232 PotentialImportedAdd
    BLAST
    Chaini33 – 571539 PotentialImportedPRO_5000225106Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_0661.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VSFX-ray2.76A/B/C/D/E/F31-520[»]
    3VSZX-ray2.89A/B/C/D/E/F31-520[»]
    3VT0X-ray2.91A/B/C/D/E/F31-520[»]
    3VT1X-ray3.19A/B/C/D/E/F31-520[»]
    3VT2X-ray3.00A/B/C/D/E/F31-520[»]
    ProteinModelPortaliA3DD67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni416 – 4205Galactose bindingImported
    Regioni431 – 4344Galactose bindingImported

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 43 family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000169275.
    OMAiANIERPK.
    OrthoDBiEOG676Z69.

    Family and domain databases

    Gene3Di1.10.1330.10. 1 hit.
    2.115.10.20. 1 hit.
    InterProiIPR016134. Cellulos_enz_dockerin_1.
    IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
    IPR018242. Dockerin_1.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR006710. Glyco_hydro_43.
    IPR023296. Glyco_hydro_beta-prop.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PANTHERiPTHR22925. PTHR22925. 1 hit.
    PfamiPF00404. Dockerin_1. 2 hits.
    PF04616. Glyco_hydro_43. 1 hit.
    PF14200. RicinB_lectin_2. 1 hit.
    [Graphical view]
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 1 hit.
    SSF63446. SSF63446. 1 hit.
    SSF75005. SSF75005. 1 hit.
    PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
    PS00018. EF_HAND_1. 1 hit.
    PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A3DD67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKKNVGLRF LSILILMALL IGNVQSFNVA AAEGVIVNGT QFKDTSGNVI    50
    HAHGGGMLKH GDYYYWYGEY RDDSNLFLGV SCYRSKDLVN WEYRGEVLSR 100
    NSAPELNHCN IERPKVMYNA STGEFVMWMH WENGINYGQA RAAVAYSKTP 150
    DGKFTYIRSF RPMQDTGVMD HGLPGYMSRD CNVFVDTDGK GYFISAANEN 200
    MDLHLYELTP DYKNIASLKA KLFVGQQREA PCLIKRNGYY YLITSGCTGW 250
    NPNQAKYAYS KDLASGWSQL YNLGNSTTYR SQPTFIIPVQ GSSGTSYLYM 300
    GDRWAGAWGG KVNDSQYVWL PLNFISDTTL ELPYYDSVKI DASSGIISEY 350
    IPDTTRYKLV NKNSGKVLDV LDGSVDNAAQ IVQWTDNGSL SQQWYLVDVG 400
    GGYKKIVNVK SGRALDVKDE SKEDGGVLIQ YTSNGGYNQH WKFTDIGDGY 450
    YKISSRHCGK LIDVRKWSTE DGGIIQQWSD AGGTNQHWKL VLVSSPEPSP 500
    SPSPQVVKGD VNGDLKVNST DFSMLRRYLL KTIDNFPTEN GKQAADLNGD 550
    GRINSSDLTM LKRYLLMEVD L 571
    Length:571
    Mass (Da):63,895
    Last modified:March 20, 2007 - v1
    Checksum:i5034D6F32BBA3CA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51896.1.
    RefSeqiYP_001037089.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN51896; ABN51896; Cthe_0661.
    GeneIDi4808191.
    KEGGicth:Cthe_0661.
    PATRICi19515007. VBICloThe47081_0694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51896.1 .
    RefSeqi YP_001037089.1. NC_009012.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VSF X-ray 2.76 A/B/C/D/E/F 31-520 [» ]
    3VSZ X-ray 2.89 A/B/C/D/E/F 31-520 [» ]
    3VT0 X-ray 2.91 A/B/C/D/E/F 31-520 [» ]
    3VT1 X-ray 3.19 A/B/C/D/E/F 31-520 [» ]
    3VT2 X-ray 3.00 A/B/C/D/E/F 31-520 [» ]
    ProteinModelPortali A3DD67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_0661.

    Protein family/group databases

    CAZyi CBM13. Carbohydrate-Binding Module Family 13.
    GH43. Glycoside Hydrolase Family 43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN51896 ; ABN51896 ; Cthe_0661 .
    GeneIDi 4808191.
    KEGGi cth:Cthe_0661.
    PATRICi 19515007. VBICloThe47081_0694.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000169275.
    OMAi ANIERPK.
    OrthoDBi EOG676Z69.

    Enzyme and pathway databases

    BioCyci CTHE203119:GIW8-685-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1330.10. 1 hit.
    2.115.10.20. 1 hit.
    InterProi IPR016134. Cellulos_enz_dockerin_1.
    IPR002105. Cellulos_enz_dockerin_1_Ca-bd.
    IPR018242. Dockerin_1.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR006710. Glyco_hydro_43.
    IPR023296. Glyco_hydro_beta-prop.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    PANTHERi PTHR22925. PTHR22925. 1 hit.
    Pfami PF00404. Dockerin_1. 2 hits.
    PF04616. Glyco_hydro_43. 1 hit.
    PF14200. RicinB_lectin_2. 1 hit.
    [Graphical view ]
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 1 hit.
    SSF63446. SSF63446. 1 hit.
    SSF75005. SSF75005. 1 hit.
    PROSITEi PS00448. CLOS_CELLULOSOME_RPT. 2 hits.
    PS00018. EF_HAND_1. 1 hit.
    PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372Imported.
    2. "Crystal structure of 1,3Gal43A, an exo-?-1,3-galactanase from Clostridium thermocellum."
      Jiang D., Fan J., Wang X., Zhao Y., Huang B., Liu J., Zhang X.C.
      J. Struct. Biol. 180:447-457(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.76 ANGSTROMS) OF 31-520 IN COMPLEX WITH GALACTOSE.

    Entry informationi

    Entry nameiA3DD67_CLOTH
    AccessioniPrimary (citable) accession number: A3DD67
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3