ID   A3DCZ0_ACET2            Unreviewed;       394 AA.
AC   A3DCZ0;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
GN   OrderedLocusNames=Cthe_0583 {ECO:0000313|EMBL:ABN51819.1};
OS   Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC
OS   103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Acetivibrio.
OX   NCBI_TaxID=203119 {ECO:0000313|EMBL:ABN51819.1, ECO:0000313|Proteomes:UP000002145};
RN   [1] {ECO:0000313|Proteomes:UP000002145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 /
RC   NRRL B-4536 / VPI 7372 {ECO:0000313|Proteomes:UP000002145};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D.,
RA   Newcomb M., Richardson P.;
RT   "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:3JTE}
RP   X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-134.
RA   Fedorov A.A., Fedorov E.V., Toro R., Sauder J.M., Burley S.K., Almo S.C.;
RT   "Crystal structure of response regulator receiver domain Protein from
RT   clostridium thermocellum.";
RL   Submitted (SEP-2009) to the PDB data bank.
RN   [3] {ECO:0000313|EMBL:ABN51819.1, ECO:0000313|Proteomes:UP000002145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 /
RC   NRRL B-4536 / VPI 7372 {ECO:0000313|Proteomes:UP000002145};
RX   PubMed=24295562; DOI=10.1186/1754-6834-6-179;
RA   Wilson C.M., Rodriguez M.Jr., Johnson C.M., Martin S.L., Chu T.M.,
RA   Wolfinger R.D., Hauser L.J., Land M.L., Klingeman D.M., Syed M.H.,
RA   Ragauskas A.J., Tschaplinski T.J., Mielenz J.R., Brown S.D.;
RT   "Global transcriptome analysis of Clostridium thermocellum ATCC 27405
RT   during growth on dilute acid pretreated Populus and switchgrass.";
RL   Biotechnol. Biofuels 6:179-179(2013).
CC   -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC       be an element of the effector pathway responsible for the activation of
CC       sporulation genes in response to nutritional stress. Spo0A may act in
CC       concert with spo0H (a sigma factor) to control the expression of some
CC       genes that are critical to the sporulation process.
CC       {ECO:0000256|ARBA:ARBA00024867}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000568; ABN51819.1; -; Genomic_DNA.
DR   RefSeq; WP_003517677.1; NC_009012.1.
DR   PDB; 3JTE; X-ray; 1.90 A; A=2-134.
DR   PDBsum; 3JTE; -.
DR   AlphaFoldDB; A3DCZ0; -.
DR   SMR; A3DCZ0; -.
DR   STRING; 203119.Cthe_0583; -.
DR   DNASU; 4808258; -.
DR   GeneID; 57419096; -.
DR   KEGG; cth:Cthe_0583; -.
DR   eggNOG; COG2204; Bacteria.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_000445_43_7_9; -.
DR   OrthoDB; 9763484at2; -.
DR   EvolutionaryTrace; A3DCZ0; -.
DR   Proteomes; UP000002145; Chromosome.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3JTE};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002145}.
FT   DOMAIN          3..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   394 AA;  43886 MW;  081E250EBCF75345 CRC64;
     MAKILVIDDE STILQNIKFL LEIDGNEVLT ASSSTEGLRI FTENCNSIDV VITDMKMPKL
     SGMDILREIK KITPHMAVII LTGHGDLDNA ILAMKEGAFE YLRKPVTAQD LSIAINNAIN
     RKKLLMENER MTQELLAHRN YLQGLHDSAA KILLNMLPKN LPDIEGFNFA VDYKSCDGVG
     GDMYDVCDIG DYICFYVFDV SHHGILAAVI SIIIKSFLQN IEYNYRQGIN KRRFPEIVLD
     LNLELLSNTA QNVFASLFLG FIDKNSKKLY TVSAGHIPQY IMKENGLVPL ESTGPILGVF
     EDSTYKCAVN QLEPGDKVLL FTDGIIESPS DSSDESSDGN QIFGYENMVK VLESCKNEPI
     STTIDKIMKA VKDFSGNRCT DDMTILGVEV LKEN
//