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Protein

Cellulose 1,4-beta-cellobiosidase

Gene

celK

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei737By similarity1
Active sitei786By similarity1
Active sitei795By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-431-MONOMER
MetaCyc:MONOMER-16421

Protein family/group databases

CAZyiCBM4 Carbohydrate-Binding Module Family 4
GH9 Glycoside Hydrolase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulose 1,4-beta-cellobiosidase (EC:3.2.1.91)
Gene namesi
Name:celK
Ordered Locus Names:Cthe_0412
ORF Names:CtheDRAFT_2165
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000028471828 – 895Cellulose 1,4-beta-cellobiosidaseAdd BLAST868

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0412

Structurei

3D structure databases

ProteinModelPortaliA3DCH1
SMRiA3DCH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 199CBM-cenCAdd BLAST160
Domaini828 – 894DockerinPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 240LinkerBy similarityAdd BLAST42
Regioni241 – 815CatalyticBy similarityAdd BLAST575

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E08 Bacteria
ENOG410XNTA LUCA
HOGENOMiHOG000245359
KOiK01179
OMAiGMNIPER
OrthoDBiPOG091H04TS

Family and domain databases

CDDicd02850 E_set_Cellulase_N, 1 hit
Gene3Di1.50.10.10, 1 hit
2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR004197 Cellulase_Ig-like
IPR003305 CenC_carb-bd
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR008979 Galactose-bd-like_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02018 CBM_4_9, 1 hit
PF02927 CelD_N, 1 hit
PF00404 Dockerin_1, 2 hits
PF00759 Glyco_hydro_9, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49785 SSF49785, 1 hit
SSF63446 SSF63446, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00448 CLOS_CELLULOSOME_RPT, 1 hit
PS51766 DOCKERIN, 1 hit
PS00592 GLYCOSYL_HYDROL_F9_1, 1 hit
PS00698 GLYCOSYL_HYDROL_F9_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3DCH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFRRMLCAA IVLTIVLSIM LPSTVFALED KSPKLPDYKN DLLYERTFDE
60 70 80 90 100
GLCFPWHTCE DSGGKCDFAV VDVPGEPGNK AFRLTVIDKG QNKWSVQMRH
110 120 130 140 150
RGITLEQGHT YTVRFTIWSD KSCRVYAKIG QMGEPYTEYW NNNWNPFNLT
160 170 180 190 200
PGQKLTVEQN FTMNYPTDDT CEFTFHLGGE LAAGTPYYVY LDDVSLYDPR
210 220 230 240 250
FVKPVEYVLP QPDVRVNQVG YLPFAKKYAT VVSSSTSPLK WQLLNSANQV
260 270 280 290 300
VLEGNTIPKG LDKDSQDYVH WIDFSNFKTE GKGYYFKLPT VNSDTNYSHP
310 320 330 340 350
FDISADIYSK MKFDALAFFY HKRSGIPIEM PYAGGEQWTR PAGHIGVAPN
360 370 380 390 400
KGDTNVPTWP QDDEYAGRPQ KYYTKDVTGG WYDAGDHGKY VVNGGIAVWT
410 420 430 440 450
LMNMYERAKI RGIANQGAYK DGGMNIPERN NGYPDILDEA RWEIEFFKKM
460 470 480 490 500
QVTEKEDPSI AGMVHHKIHD FRWTALGMLP HEDPQPRYLR PVSTAATLNF
510 520 530 540 550
AATLAQSARL WKDYDPTFAA DCLEKAEIAW QAALKHPDIY AEYTPGSGGP
560 570 580 590 600
GGGPYNDDYV GDEFYWAACE LYVTTGKDEY KNYLMNSPHY LEMPAKMGEN
610 620 630 640 650
GGANGEDNGL WGCFTWGTTQ GLGTITLALV ENGLPSADIQ KARNNIAKAA
660 670 680 690 700
DKWLENIEEQ GYRLPIKQAE DERGGYPWGS NSFILNQMIV MGYAYDFTGN
710 720 730 740 750
SKYLDGMQDG MSYLLGRNGL DQSYVTGYGE RPLQNPHDRF WTPQTSKKFP
760 770 780 790 800
APPPGIIAGG PNSRFEDPTI TAAVKKDTPP QKCYIDHTDS WSTNEITINW
810 820 830 840 850
NAPFAWVTAY LDEIDLITPP GGVDPEEPEV IYGDCNGDGK VNSTDAVALK
860 870 880 890
RYILRSGISI NTDNADVNAD GRVNSTDLAI LKRYILKEID VLPHK
Length:895
Mass (Da):100,622
Last modified:March 20, 2007 - v1
Checksum:i9354DFE9EC75BE67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN51650.1
RefSeqiWP_011837826.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN51650; ABN51650; Cthe_0412
GeneIDi35806154
KEGGicth:Cthe_0412

Similar proteinsi

Entry informationi

Entry nameiCELK_CLOTH
AccessioniPrimary (citable) accession number: A3DCH1
Secondary accession number(s): O68438, Q10748, Q4CGG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health