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A3DBX9

- G6PI_CLOTH

UniProt

A3DBX9 - G6PI_CLOTH

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901Proton donorUniRule annotation
    Active sitei311 – 3111UniRule annotation
    Active sitei425 – 4251UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-223-MONOMER.
    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:Cthe_0217
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Glucose-6-phosphate isomerasePRO_1000013960Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_0217.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DBX9.
    SMRiA3DBX9. Positions 4-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiLANFNPK.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3DBX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIKFDYSK ALPFVSEREV AYFENFVRSA HDMLHNKTGA GNDFVGWVDL    50
    PVNYDREEFA RIKAAAEKIK SDSDALVVIG IGGSYLGARA AIEMLSHSFH 100
    NLMPKSKRNA PEIYFVGNNI SSTYIADLLE VIEGKEISVN VISKSGTTTE 150
    PAIAFRIFKE YMENKYGKDG ASKRIYATTD KEKGALRKLA TEEGYETFVV 200
    PDDIGGRFSV LTAVGLLPIA VAGIDIDSMM KGAADARELY SNPNLMENDC 250
    YKYAAVRNAL YRKNKTIEIM VNYEPSLHYF TEWWKQLYGE SEGKDQKGIF 300
    PAGVDFTTDL HSMGQYIQDG LRNIFETVIR VEKPRKNIVI KEEKDNLDGL 350
    NFIAGKDVDY VNKKAMEGTV LAHTDGGVPN LVVTVPELSA YYFGNMVYFF 400
    EKACGISGYL LGVNPFDQPG VEAYKKNMFA LLGKPGYEEQ RKKLEERL 448
    Length:448
    Mass (Da):50,287
    Last modified:March 20, 2007 - v1
    Checksum:iC2B06430611EFE7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51458.1.
    RefSeqiYP_001036651.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN51458; ABN51458; Cthe_0217.
    GeneIDi4808635.
    KEGGicth:Cthe_0217.
    PATRICi19514067. VBICloThe47081_0232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51458.1 .
    RefSeqi YP_001036651.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali A3DBX9.
    SMRi A3DBX9. Positions 4-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_0217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN51458 ; ABN51458 ; Cthe_0217 .
    GeneIDi 4808635.
    KEGGi cth:Cthe_0217.
    PATRICi 19514067. VBICloThe47081_0232.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi LANFNPK.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .
    BioCyci CTHE203119:GIW8-223-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiG6PI_CLOTH
    AccessioniPrimary (citable) accession number: A3DBX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3