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A3DBL4

- TRMB_CLOTH

UniProt

A3DBL4 - TRMB_CLOTH

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Cthe_0102
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431S-adenosyl-L-methionine By similarity
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei101 – 1011S-adenosyl-L-methionine By similarity
Binding sitei124 – 1241S-adenosyl-L-methionine By similarity
Binding sitei128 – 1281Substrate By similarity
Binding sitei160 – 1601Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-102-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:Cthe_0102
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288142Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_0102.

    Structurei

    3D structure databases

    ProteinModelPortaliA3DBL4.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiDNVMTEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR022272. Lipocalin_CS.
    IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3DBL4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLRKKPWAR PALEACSFFV INPTEYKGKW REVFGNSNEI WLELGCGKGG    50
    FISKLASTNP DKNFIAVDIK DEVLALAMKK IENEYALIGA ETKNIRLMAH 100
    EIMLIHRMLD ENDQIGRIFI NFCNPWPKNR HKARRLTHPN QLNQYRTFLA 150
    PNGQIWFKTD DTMLFQDSIK YFEQCNFNIV YLTEDLHASG FEGNIETEHE 200
    RMFLEQGCKI KFLIAEKK 218
    Length:218
    Mass (Da):25,550
    Last modified:March 20, 2007 - v1
    Checksum:i6AC2B754C1F2485F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51343.1.
    RefSeqiYP_001036536.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN51343; ABN51343; Cthe_0102.
    GeneIDi4808726.
    KEGGicth:Cthe_0102.
    PATRICi19513815. VBICloThe47081_0110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000568 Genomic DNA. Translation: ABN51343.1 .
    RefSeqi YP_001036536.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali A3DBL4.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_0102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN51343 ; ABN51343 ; Cthe_0102 .
    GeneIDi 4808726.
    KEGGi cth:Cthe_0102.
    PATRICi 19513815. VBICloThe47081_0110.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi DNVMTEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CTHE203119:GIW8-102-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR022272. Lipocalin_CS.
    IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237.

    Entry informationi

    Entry nameiTRMB_CLOTH
    AccessioniPrimary (citable) accession number: A3DBL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 20, 2007
    Last modified: September 3, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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