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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Sbal_3364
OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
Taxonomic identifieri325240 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000216251 – 360Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST360

Proteomic databases

PRIDEiA3D7X8

Interactioni

Protein-protein interaction databases

STRINGi325240.Sbal_3364

Structurei

3D structure databases

ProteinModelPortaliA3D7X8
SMRiA3D7X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263500
KOiK00768
OMAiQMATFAE

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

A3D7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSAVSFQI SPVSKTQDPL IQQKIDLKTK PPGALGQLES LALQIARVQA
60 70 80 90 100
TDSQQTDQPQ NTVLKIVQPT MLVFAGDHGI AAEGVSIAPS EVTRQMVQNF
110 120 130 140 150
AHGGAAINVF CRQVGFTLEV IDCGILTPVE GVEGIIDQRL GAGTGAIHLE
160 170 180 190 200
PAMALETVDK GFAMARDLIE RHHQAGCNLV AFGEMGIGNT SAAAAIMAAI
210 220 230 240 250
MQLDVIDCVG RGTGINSETL ERKLMLIELA LLLHQSALTG PKSVLACLGG
260 270 280 290 300
FEIVQMTGAM LAAAERKMLV VVDGFIATAA ALVAVQIAPN VRDYLIFAHQ
310 320 330 340 350
SDEQGHKRML EFLQAKPLLS LGLRLGEGTG AALALPLIQA SVNFYNQMAS
360
FSDAGIEAVV
Length:360
Mass (Da):37,945
Last modified:March 20, 2007 - v1
Checksum:i1BCFB276889C1E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000563 Genomic DNA Translation: ABN62841.1
RefSeqiWP_011847602.1, NC_009052.1

Genome annotation databases

EnsemblBacteriaiABN62841; ABN62841; Sbal_3364
KEGGisbl:Sbal_3364

Entry informationi

Entry nameiCOBT_SHEB5
AccessioniPrimary (citable) accession number: A3D7X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health