SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3D367

- RIBA_SHEB5

UniProt

A3D367 - RIBA_SHEB5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
GTP cyclohydrolase-2
Gene
ribA, Sbal_1668
Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc; catalytic By similarity
Metal bindingi65 – 651Zinc; catalytic By similarity
Metal bindingi67 – 671Zinc; catalytic By similarity
Binding sitei70 – 701GTP By similarity
Binding sitei114 – 1141GTP By similarity
Active sitei126 – 1261Proton acceptor Reviewed prediction
Active sitei128 – 1281Nucleophile By similarity
Binding sitei149 – 1491GTP By similarity
Binding sitei154 – 1541GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 535GTP By similarity
Nucleotide bindingi92 – 943GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSBAL325240:GCTA-1697-MONOMER.
UniPathwayiUPA00275; UER00400.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2 (EC:3.5.4.25)
Alternative name(s):
GTP cyclohydrolase II
Gene namesi
Name:ribA
Ordered Locus Names:Sbal_1668
OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
Taxonomic identifieri325240 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204GTP cyclohydrolase-2UniRule annotation
PRO_1000040579Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi325240.Sbal_1668.

Structurei

3D structure databases

ProteinModelPortaliA3D367.
SMRiA3D367. Positions 1-173.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0807.
HOGENOMiHOG000115442.
KOiK01497.
OMAiQGFILYL.
OrthoDBiEOG679TK8.

Family and domain databases

HAMAPiMF_00179. RibA.
InterProiIPR000926. GTP_CycHdrlaseII_RibA.
[Graphical view]
PfamiPF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00505. ribA. 1 hit.

Sequencei

Sequence statusi: Complete.

A3D367-1 [UniParc]FASTAAdd to Basket

« Hide

MSIKYVATSK LPTPWGVFAM HGFEDTESGK EHVALTFGTL SADEPVLGRI    50
HSECLTGDAL FSLRCDCGFQ LQAAMQNIAE TGSGFILYLR QEGRGIGLLN 100
KIRAYELQDK GANTVEANEQ LGFEADMRKY DMIKPILEQI GVKHVRLMTN 150
NPRKVKAMKE FGIEVVERVP LQVGKNRYNE AYLKTKSTEL GHMMSEYHFM 200
DENK 204
Length:204
Mass (Da):22,997
Last modified:March 20, 2007 - v1
Checksum:i81F61281BD8FAA24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN61180.1.
RefSeqiYP_001050049.1. NC_009052.1.

Genome annotation databases

EnsemblBacteriaiABN61180; ABN61180; Sbal_1668.
GeneIDi4844764.
KEGGisbl:Sbal_1668.
PATRICi37182199. VBISheBal55297_1948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN61180.1 .
RefSeqi YP_001050049.1. NC_009052.1.

3D structure databases

ProteinModelPortali A3D367.
SMRi A3D367. Positions 1-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 325240.Sbal_1668.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN61180 ; ABN61180 ; Sbal_1668 .
GeneIDi 4844764.
KEGGi sbl:Sbal_1668.
PATRICi 37182199. VBISheBal55297_1948.

Phylogenomic databases

eggNOGi COG0807.
HOGENOMi HOG000115442.
KOi K01497.
OMAi QGFILYL.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00400 .
BioCyci SBAL325240:GCTA-1697-MONOMER.

Family and domain databases

HAMAPi MF_00179. RibA.
InterProi IPR000926. GTP_CycHdrlaseII_RibA.
[Graphical view ]
Pfami PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00505. ribA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS155 / ATCC BAA-1091.

Entry informationi

Entry nameiRIBA_SHEB5
AccessioniPrimary (citable) accession number: A3D367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi