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A3D367

- RIBA_SHEB5

UniProt

A3D367 - RIBA_SHEB5

Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

    Catalytic activityi

    GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Zinc; catalyticUniRule annotation
    Metal bindingi65 – 651Zinc; catalyticUniRule annotation
    Metal bindingi67 – 671Zinc; catalyticUniRule annotation
    Binding sitei70 – 701GTPUniRule annotation
    Binding sitei114 – 1141GTPUniRule annotation
    Active sitei126 – 1261Proton acceptorUniRule annotation
    Active sitei128 – 1281NucleophileUniRule annotation
    Binding sitei149 – 1491GTPUniRule annotation
    Binding sitei154 – 1541GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 535GTPUniRule annotation
    Nucleotide bindingi92 – 943GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSBAL325240:GCTA-1697-MONOMER.
    UniPathwayiUPA00275; UER00400.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IIUniRule annotation
    Gene namesi
    Name:ribAUniRule annotation
    Ordered Locus Names:Sbal_1668
    OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
    Taxonomic identifieri325240 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204GTP cyclohydrolase-2PRO_1000040579Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi325240.Sbal_1668.

    Structurei

    3D structure databases

    ProteinModelPortaliA3D367.
    SMRiA3D367. Positions 1-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase II family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0807.
    HOGENOMiHOG000115442.
    KOiK01497.
    OMAiQGFILYL.
    OrthoDBiEOG679TK8.

    Family and domain databases

    HAMAPiMF_00179. RibA.
    InterProiIPR000926. GTP_CycHdrlaseII_RibA.
    [Graphical view]
    PfamiPF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00505. ribA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3D367-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIKYVATSK LPTPWGVFAM HGFEDTESGK EHVALTFGTL SADEPVLGRI    50
    HSECLTGDAL FSLRCDCGFQ LQAAMQNIAE TGSGFILYLR QEGRGIGLLN 100
    KIRAYELQDK GANTVEANEQ LGFEADMRKY DMIKPILEQI GVKHVRLMTN 150
    NPRKVKAMKE FGIEVVERVP LQVGKNRYNE AYLKTKSTEL GHMMSEYHFM 200
    DENK 204
    Length:204
    Mass (Da):22,997
    Last modified:March 20, 2007 - v1
    Checksum:i81F61281BD8FAA24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN61180.1.
    RefSeqiYP_001050049.1. NC_009052.1.

    Genome annotation databases

    EnsemblBacteriaiABN61180; ABN61180; Sbal_1668.
    GeneIDi4844764.
    KEGGisbl:Sbal_1668.
    PATRICi37182199. VBISheBal55297_1948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN61180.1 .
    RefSeqi YP_001050049.1. NC_009052.1.

    3D structure databases

    ProteinModelPortali A3D367.
    SMRi A3D367. Positions 1-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 325240.Sbal_1668.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN61180 ; ABN61180 ; Sbal_1668 .
    GeneIDi 4844764.
    KEGGi sbl:Sbal_1668.
    PATRICi 37182199. VBISheBal55297_1948.

    Phylogenomic databases

    eggNOGi COG0807.
    HOGENOMi HOG000115442.
    KOi K01497.
    OMAi QGFILYL.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00400 .
    BioCyci SBAL325240:GCTA-1697-MONOMER.

    Family and domain databases

    HAMAPi MF_00179. RibA.
    InterProi IPR000926. GTP_CycHdrlaseII_RibA.
    [Graphical view ]
    Pfami PF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00505. ribA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS155 / ATCC BAA-1091.

    Entry informationi

    Entry nameiRIBA_SHEB5
    AccessioniPrimary (citable) accession number: A3D367
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3